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Gene Review

Cyth1  -  cytohesin 1

Mus musculus

Synonyms: CLM1, CTH-1, CYTIP, Cytohesin-1, PH, SEC7 and coiled-coil domain-containing protein 1, ...
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High impact information on Pscd1

  • GRP1 and cytohesin-1 appear to connect receptor-activated PI 3-kinase signaling pathways with proteins that mediate biological responses such as cell adhesion and membrane trafficking [1].
  • Cytohesin-1 is an intracellular guanine nucleotide exchange factor, which regulates leukocyte adhesion [2].
  • Consequently, stimulated adhesion of Jurkat cells to intracellular adhesion molecule-1 is repressed by CYTIP [2].
  • Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration [2].
  • This molecule, CYTIP, is also recruited to the cell cortex by integrin signaling via its PDZ domain [2].

Biological context of Pscd1


Associations of Pscd1 with chemical compounds


Analytical, diagnostic and therapeutic context of Pscd1

  • The relative expression patterns of CLM1, 2, 3 and their transcriptional alternatives were determined by RT-PCR, nucleotide sequencing and RNA blotting [6].


  1. Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Klarlund, J.K., Guilherme, A., Holik, J.J., Virbasius, J.V., Chawla, A., Czech, M.P. Science (1997) [Pubmed]
  2. Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration. Boehm, T., Hofer, S., Winklehner, P., Kellersch, B., Geiger, C., Trockenbacher, A., Neyer, S., Fiegl, H., Ebner, S., Ivarsson, L., Schneider, R., Kremmer, E., Heufler, C., Kolanus, W. EMBO J. (2003) [Pubmed]
  3. The scaffold protein Cybr is required for cytokine-modulated trafficking of leukocytes in vivo. Coppola, V., Barrick, C.A., Bobisse, S., Rodriguez-Galan, M.C., Pivetta, M., Reynolds, D., Howard, O.M., Palko, M.E., Esteban, P.F., Young, H.A., Rosato, A., Tessarollo, L. Mol. Cell. Biol. (2006) [Pubmed]
  4. Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance. Hafner, M., Schmitz, A., Gr??ne, I., Srivatsan, S.G., Paul, B., Kolanus, W., Quast, T., Kremmer, E., Bauer, I., Famulok, M. Nature (2006) [Pubmed]
  5. Cloning and characterization of the promoter of murine cytohesin-1 gene. Goda, N., Tanoue, A., Kikuchi, S., Tsujimoto, G. Biochim. Biophys. Acta (2000) [Pubmed]
  6. Complex regulation of multiple cytohesin-like genes in murine tissues and cells. Kim, H.S., Chen, Y., Lonai, P. FEBS Lett. (1998) [Pubmed]
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