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Gene Review

Cav3  -  caveolin 3

Mus musculus

Synonyms: AI385751, Cav-3, Caveolin-3, M-cav, M-caveolin
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Disease relevance of Cav3


High impact information on Cav3


Chemical compound and disease context of Cav3


Biological context of Cav3


Anatomical context of Cav3


Associations of Cav3 with chemical compounds


Physical interactions of Cav3


Co-localisations of Cav3


Regulatory relationships of Cav3


Other interactions of Cav3


Analytical, diagnostic and therapeutic context of Cav3


  1. Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype. Park, D.S., Woodman, S.E., Schubert, W., Cohen, A.W., Frank, P.G., Chandra, M., Shirani, J., Razani, B., Tang, B., Jelicks, L.A., Factor, S.M., Weiss, L.M., Tanowitz, H.B., Lisanti, M.P. Am. J. Pathol. (2002) [Pubmed]
  2. Phosphofructokinase muscle-specific isoform requires caveolin-3 expression for plasma membrane recruitment and caveolar targeting: implications for the pathogenesis of caveolin-related muscle diseases. Sotgia, F., Bonuccelli, G., Minetti, C., Woodman, S.E., Capozza, F., Kemp, R.G., Scherer, P.E., Lisanti, M.P. Am. J. Pathol. (2003) [Pubmed]
  3. Transgenic overexpression of caveolin-3 in skeletal muscle fibers induces a Duchenne-like muscular dystrophy phenotype. Galbiati, F., Volonte, D., Chu, J.B., Li, M., Fine, S.W., Fu, M., Bermudez, J., Pedemonte, M., Weidenheim, K.M., Pestell, R.G., Minetti, C., Lisanti, M.P. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. Transgenic mice expressing mutant caveolin-3 show severe myopathy associated with increased nNOS activity. Sunada, Y., Ohi, H., Hase, A., Ohi, H., Hosono, T., Arata, S., Higuchi, S., Matsumura, K., Shimizu, T. Hum. Mol. Genet. (2001) [Pubmed]
  5. Caveolin-3 associates with developing T-tubules during muscle differentiation. Parton, R.G., Way, M., Zorzi, N., Stang, E. J. Cell Biol. (1997) [Pubmed]
  6. Insulin resistance in skeletal muscles of caveolin-3-null mice. Oshikawa, J., Otsu, K., Toya, Y., Tsunematsu, T., Hankins, R., Kawabe, J., Minamisawa, S., Umemura, S., Hagiwara, Y., Ishikawa, Y. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  7. Caveolin-3 knockout mice show increased adiposity and whole body insulin resistance, with ligand-induced insulin receptor instability in skeletal muscle. Capozza, F., Combs, T.P., Cohen, A.W., Cho, Y.R., Park, S.Y., Schubert, W., Williams, T.M., Brasaemle, D.L., Jelicks, L.A., Scherer, P.E., Kim, J.K., Lisanti, M.P. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  8. Caveolin proteins in signaling, oncogenic transformation and muscular dystrophy. Razani, B., Schlegel, A., Lisanti, M.P. J. Cell. Sci. (2000) [Pubmed]
  9. A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes. Smythe, G.M., Eby, J.C., Disatnik, M.H., Rando, T.A. J. Cell. Sci. (2003) [Pubmed]
  10. Caveolin-3 is associated with the T-tubules of mature skeletal muscle fibers. Ralston, E., Ploug, T. Exp. Cell Res. (1999) [Pubmed]
  11. Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins. Song, K.S., Scherer, P.E., Tang, Z., Okamoto, T., Li, S., Chafel, M., Chu, C., Kohtz, D.S., Lisanti, M.P. J. Biol. Chem. (1996) [Pubmed]
  12. Modulation of myoblast fusion by caveolin-3 in dystrophic skeletal muscle cells: implications for Duchenne muscular dystrophy and limb-girdle muscular dystrophy-1C. Volonte, D., Peoples, A.J., Galbiati, F. Mol. Biol. Cell (2003) [Pubmed]
  13. Role of cholesterol in developing T-tubules: analogous mechanisms for T-tubule and caveolae biogenesis. Carozzi, A.J., Ikonen, E., Lindsay, M.R., Parton, R.G. Traffic (2000) [Pubmed]
  14. Localization of cardiac L-type Ca(2+) channels to a caveolar macromolecular signaling complex is required for beta(2)-adrenergic regulation. Balijepalli, R.C., Foell, J.D., Hall, D.D., Hell, J.W., Kamp, T.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  15. Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes. Xiang, Y., Rybin, V.O., Steinberg, S.F., Kobilka, B. J. Biol. Chem. (2002) [Pubmed]
  16. NO synthase II in mouse skeletal muscle is associated with caveolin 3. Gath, I., Ebert, J., Gödtel-Armbrust, U., Ross, R., Reske-Kunz, A.B., Förstermann, U. Biochem. J. (1999) [Pubmed]
  17. Neuregulin receptor ErbB2 localization at T-tubule in cardiac and skeletal muscle. Ueda, H., Oikawa, A., Nakamura, A., Terasawa, F., Kawagishi, K., Moriizumi, T. J. Histochem. Cytochem. (2005) [Pubmed]
  18. Effects of alpha1-adrenergic stimulation on normal and hypertrophied mouse hearts. Relation to caveolin-3 expression. Petrashevskaya, N.N., Bodi, I., Koch, S.E., Akhter, S.A., Schwartz, A. Cardiovasc. Res. (2004) [Pubmed]
  19. Muscle-specific interaction of caveolin isoforms: differential complex formation between caveolins in fibroblastic vs. muscle cells. Capozza, F., Cohen, A.W., Cheung, M.W., Sotgia, F., Schubert, W., Battista, M., Lee, H., Frank, P.G., Lisanti, M.P. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  20. Intracellular localization of dysferlin and its association with the dihydropyridine receptor. Ampong, B.N., Imamura, M., Matsumiya, T., Yoshida, M., Takeda, S. Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology / edited by the Gaetano Conte Academy for the study of striated muscle diseases. (2005) [Pubmed]
  21. Colocalization between caveolin isoforms in the intestinal smooth muscle and interstitial cells of Cajal of the Cav1(+/+) and Cav1 (-/-) mouse. Cho, W.J., Daniel, E.E. Histochem. Cell Biol. (2006) [Pubmed]
  22. Identification of intracellular signaling pathways that induce myotonic dystrophy protein kinase expression during myogenesis. Carrasco, M., Canicio, J., Palacín, M., Zorzano, A., Kaliman, P. Endocrinology (2002) [Pubmed]
  23. Increased Rho activation and PKC-mediated smooth muscle contractility in the absence of caveolin-1. Shakirova, Y., Bonnevier, J., Albinsson, S., Adner, M., Rippe, B., Broman, J., Arner, A., Sw??rd, K. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  24. Differential expression of caveolin-3 in mouse smooth muscle cells in vivo. Kogo, H., Ito, S.Y., Moritoki, Y., Kurahashi, H., Fujimoto, T. Cell Tissue Res. (2006) [Pubmed]
  25. Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism. Martin, S., Driessen, K., Nixon, S.J., Zerial, M., Parton, R.G. J. Biol. Chem. (2005) [Pubmed]
  26. Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade. Woodman, S.E., Park, D.S., Cohen, A.W., Cheung, M.W., Chandra, M., Shirani, J., Tang, B., Jelicks, L.A., Kitsis, R.N., Christ, G.J., Factor, S.M., Tanowitz, H.B., Lisanti, M.P. J. Biol. Chem. (2002) [Pubmed]
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