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Gene Review

Rad23b  -  RAD23b homolog (S. cerevisiae)

Mus musculus

Synonyms: 0610007D13Rik, AV001138, HR23B, Mhr23b, UV excision repair protein RAD23 homolog B, ...
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Disease relevance of Rad23b


High impact information on Rad23b

  • Because p97 is known to bind to the endoplasmic reticulum membrane protein AMFR (gp78), an E3 ligase, we propose a model in which p97, mPNGase, and mHR23B mediate interaction of the endoplasmic reticulum with the proteasome [2].
  • In agreement with the results of in vitro repair studies, this indicates that mHR23A can functionally replace mHR23B in NER [1].
  • Unlike XPC-deficient cells, mHR23B(-/-) mouse embryonic fibroblasts are not UV sensitive and retain the repair characteristics of wild-type cells [1].
  • Unexpectedly, mHR23B(-/-) mice show impaired embryonic development and a high rate (90%) of intrauterine or neonatal death [1].
  • Part of mHR23B is complexed with the XPC protein, and this heterodimer functions as the main damage detector and initiator of global genome NER [1].

Biological context of Rad23b

  • From our analyses, we found impaired reproduction in heterozygous and homozygous knock out mice; in particular, reduced litter size and lengthened pbi was related to the NER mutation-mHR23B, in heterozygous couples, even if they were otherwise phenotypically normal [3].


  1. Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B. Ng, J.M., Vrieling, H., Sugasawa, K., Ooms, M.P., Grootegoed, J.A., Vreeburg, J.T., Visser, P., Beems, R.B., Gorgels, T.G., Hanaoka, F., Hoeijmakers, J.H., van der Horst, G.T. Mol. Cell. Biol. (2002) [Pubmed]
  2. Multiple modes of interaction of the deglycosylation enzyme, mouse peptide N-glycanase, with the proteasome. Li, G., Zhou, X., Zhao, G., Schindelin, H., Lennarz, W.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. The effect of DNA repair defects on reproductive performance in nucleotide excision repair (NER) mouse models: an epidemiological approach. Tsai, P.S., Nielen, M., van der Horst, G.T., Colenbrander, B., Heesterbeek, J.A., van Vlissingen, J.M. Transgenic Res. (2005) [Pubmed]
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