Gene Review:
XPC - xeroderma pigmentosum, complementation...
Homo sapiens
Synonyms:
DNA repair protein complementing XP-C cells, RAD4, XP3, XPCC, Xeroderma pigmentosum group C-complementing protein, ...
Försti,
Angelini,
Festa,
Sanyal,
Zhang,
Grzybowska,
Pamula,
Pekala,
Zientek,
Hemminki,
Kumar,
Biard,
Despras,
Sarasin,
Angulo,
Sugasawa,
Okamoto,
Shimizu,
Masutani,
Iwai,
Hanaoka,
Weiss,
Weiss,
Ulrich,
Doherty,
Voigt,
Chen,
Sugasawa,
Okuda,
Saijo,
Nishi,
Matsuda,
Chu,
Mori,
Iwai,
Tanaka,
Tanaka,
Hanaoka,
- Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase. Shimizu, Y., Iwai, S., Hanaoka, F., Sugasawa, K. EMBO J. (2003)
- Interindividual variation in nucleotide excision repair genes and risk of endometrial cancer. Weiss, J.M., Weiss, N.S., Ulrich, C.M., Doherty, J.A., Voigt, L.F., Chen, C. Cancer Epidemiol. Biomarkers Prev. (2005)
- Combinations of polymorphisms in XPD, XPC and XPA in relation to risk of lung cancer. Vogel, U., Overvad, K., Wallin, H., Tjønneland, A., Nexø, B.A., Raaschou-Nielsen, O. Cancer Lett. (2005)
- Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair. Takebayashi, Y., Pourquier, P., Zimonjic, D.B., Nakayama, K., Emmert, S., Ueda, T., Urasaki, Y., Kanzaki, A., Akiyama, S.I., Popescu, N., Kraemer, K.H., Pommier, Y. Nat. Med. (2001)
- Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis. Hollander, M.C., Philburn, R.T., Patterson, A.D., Velasco-Miguel, S., Friedberg, E.C., Linnoila, R.I., Fornace, A.J. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Associations between XPC expression, genotype, and the risk of head and neck cancer. Yang, M., Kang, M.J., Choi, Y., Kim, C.S., Lee, S.M., Park, C.W., Lee, H.S., Tae, K. Environ. Mol. Mutagen. (2005)
- UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex. Sugasawa, K., Okuda, Y., Saijo, M., Nishi, R., Matsuda, N., Chu, G., Mori, T., Iwai, S., Tanaka, K., Tanaka, K., Hanaoka, F. Cell (2005)
- Characterization of molecular defects in xeroderma pigmentosum group C. Li, L., Bales, E.S., Peterson, C.A., Legerski, R.J. Nat. Genet. (1993)
- High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC. Sands, A.T., Abuin, A., Sanchez, A., Conti, C.J., Bradley, A. Nature (1995)
- A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein. Ng, J.M., Vermeulen, W., van der Horst, G.T., Bergink, S., Sugasawa, K., Vrieling, H., Hoeijmakers, J.H. Genes Dev. (2003)
- Development of new EBV-based vectors for stable expression of small interfering RNA to mimick human syndromes: application to NER gene silencing. Biard, D.S., Despras, E., Sarasin, A., Angulo, J.F. Mol. Cancer Res. (2005)
- Isolation of a cDNA encoding a UV-damaged DNA binding factor defective in xeroderma pigmentosum group E cells. Hwang, B.J., Liao, J.C., Chu, G. Mutat. Res. (1996)
- Two essential splice lariat branchpoint sequences in one intron in a xeroderma pigmentosum DNA repair gene: mutations result in reduced XPC mRNA levels that correlate with cancer risk. Khan, S.G., Metin, A., Gozukara, E., Inui, H., Shahlavi, T., Muniz-Medina, V., Baker, C.C., Ueda, T., Aiken, J.R., Schneider, T.D., Kraemer, K.H. Hum. Mol. Genet. (2004)
- Caffeine inhibits gene-specific repair of UV-induced DNA damage in hamster cells and in human xeroderma pigmentosum group C cells. Link, C.J., Evans, M.K., Cook, J.A., Muldoon, R., Stevnsner, T., Bohr, V.A. Carcinogenesis (1995)
- The XPC poly-AT polymorphism in non-melanoma skin cancer. Nelson, H.H., Christensen, B., Karagas, M.R. Cancer Lett. (2005)
- Mechanism of open complex and dual incision formation by human nucleotide excision repair factors. Evans, E., Moggs, J.G., Hwang, J.R., Egly, J.M., Wood, R.D. EMBO J. (1997)
- New functions of XPC in the protection of human skin cells from oxidative damage. D'Errico, M., Parlanti, E., Teson, M., de Jesus, B.M., Degan, P., Calcagnile, A., Jaruga, P., Bjørås, M., Crescenzi, M., Pedrini, A.M., Egly, J.M., Zambruno, G., Stefanini, M., Dizdaroglu, M., Dogliotti, E. EMBO J. (2006)
- Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair. Araki, M., Masutani, C., Takemura, M., Uchida, A., Sugasawa, K., Kondoh, J., Ohkuma, Y., Hanaoka, F. J. Biol. Chem. (2001)
- The Involvement of Ataxia-telangiectasia Mutated Protein Activation in Nucleotide Excision Repair-facilitated Cell Survival with Cisplatin Treatment. Colton, S.L., Xu, X.S., Wang, Y.A., Wang, G. J. Biol. Chem. (2006)
- UV radiation-induced XPC translocation within chromatin is mediated by damaged-DNA binding protein, DDB2. Wang, Q.E., Zhu, Q., Wani, G., Chen, J., Wani, A.A. Carcinogenesis (2004)
- Human nucleotide excision repair efficiently removes chromium-DNA phosphate adducts and protects cells against chromate toxicity. Reynolds, M., Peterson, E., Quievryn, G., Zhitkovich, A. J. Biol. Chem. (2004)
- Complementation of the DNA repair deficiency in human xeroderma pigmentosum group a and C cells by recombinant adenovirus-mediated gene transfer. Muotri, A.R., Marchetto, M.C., Zerbini, L.F., Libermann, T.A., Ventura, A.M., Sarasin, A., Menck, C.F. Hum. Gene Ther. (2002)
- In vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene product. Fitch, M.E., Nakajima, S., Yasui, A., Ford, J.M. J. Biol. Chem. (2003)
- XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes. van der Spek, P.J., Eker, A., Rademakers, S., Visser, C., Sugasawa, K., Masutani, C., Hanaoka, F., Bootsma, D., Hoeijmakers, J.H. Nucleic Acids Res. (1996)
- Proficient global nucleotide excision repair in human keratinocytes but not in fibroblasts deficient in p53. Ferguson, B.E., Oh, D.H. Cancer Res. (2005)
- Mutational inactivation of the xeroderma pigmentosum group C gene confers predisposition to 2-acetylaminofluorene-induced liver and lung cancer and to spontaneous testicular cancer in Trp53-/- mice. Cheo, D.L., Burns, D.K., Meira, L.B., Houle, J.F., Friedberg, E.C. Cancer Res. (1999)
- Biochemical analysis of the damage recognition process in nucleotide excision repair. You, J.S., Wang, M., Lee, S.H. J. Biol. Chem. (2003)
- Flexibility and plasticity of human centrin 2 binding to the xeroderma pigmentosum group C protein (XPC) from nuclear excision repair. Yang, A., Miron, S., Mouawad, L., Duchambon, P., Blouquit, Y., Craescu, C.T. Biochemistry (2006)
- Structure of the XPC binding domain of hHR23A reveals hydrophobic patches for protein interaction. Kamionka, M., Feigon, J. Protein Sci. (2004)
- Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites. Batty, D., Rapic'-Otrin, V., Levine, A.S., Wood, R.D. J. Mol. Biol. (2000)
- Interactions of the transcription/DNA repair factor TFIIH and XP repair proteins with DNA lesions in a cell-free repair assay. Li, R.Y., Calsou, P., Jones, C.J., Salles, B. J. Mol. Biol. (1998)
- Evidence for two independent pathways of biologically effective excision repair from its rate and extent in cells cultured from sun-sensitive humans. Tyrrell, R.M., Amaudruz, F. Cancer Res. (1987)
- Sequential assembly of the nucleotide excision repair factors in vivo. Volker, M., Moné, M.J., Karmakar, P., van Hoffen, A., Schul, W., Vermeulen, W., Hoeijmakers, J.H., van Driel, R., van Zeeland, A.A., Mullenders, L.H. Mol. Cell (2001)
- Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome. Araújo, S.J., Nigg, E.A., Wood, R.D. Mol. Cell. Biol. (2001)
- Single nucleotide polymorphisms in breast cancer. Försti, A., Angelini, S., Festa, F., Sanyal, S., Zhang, Z., Grzybowska, E., Pamula, J., Pekala, W., Zientek, H., Hemminki, K., Kumar, R. Oncol. Rep. (2004)
- DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiation. Wang, Q.E., Zhu, Q., Wani, G., El-Mahdy, M.A., Li, J., Wani, A.A. Nucleic Acids Res. (2005)
- A multistep damage recognition mechanism for global genomic nucleotide excision repair. Sugasawa, K., Okamoto, T., Shimizu, Y., Masutani, C., Iwai, S., Hanaoka, F. Genes Dev. (2001)