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Gene Review

Sgca  -  sarcoglycan, alpha (dystrophin-associated...

Mus musculus

Synonyms: 50 kDa dystrophin-associated glycoprotein, 50DAG, Adhalin, Alpha-SG, Alpha-sarcoglycan, ...
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Disease relevance of Sgca


High impact information on Sgca


Chemical compound and disease context of Sgca


Biological context of Sgca

  • EDL muscle of Sgca-null mice showed twitch and tetanic kinetics comparable with those of wild-type controls [6].
  • Adhalin expression in embryonic mouse muscle was coincident with primary myogenesis [8].
  • We conclude that the alpha-SG promoter is activated by MyoD, which interacts with TFIID and TFIIB in a protein complex differentially located at the distal promoter and around the proximal promoter during myogenic cell differentiation [9].

Anatomical context of Sgca

  • In contrast to the EDL, soleus muscle of Sgca-null mice contained a higher number of regenerating fibers and thus higher levels of embryonic MHC [6].
  • Contrary to EDL fibers, soleus muscle fibers of Sgca-null mice distinctively showed right shift of the pCa-tension (pCa is the negative log of Ca2+ concentration) relationships and reduced sensitivity to caffeine of sarcoplasmic reticulum [6].
  • Muscle masses were 40-100% larger for Sgca-null compared with age- and gender-matched wild-type mice, with the majority of the increased muscle mass for Sgca-null mice attributable to greater connective tissue and water contents [10].
  • This work describes the culture of Sol8 cell line that expresses neither dystrophin nor adhalin, a dystrophin-associated protein [11].
  • Additionally, members of the sarcolemmal dystrophin-glycoprotein complex (i.e., dystrophin, adhalin, beta1-dystroglycan) immunolocalize in the cytosol of differentiating myoblasts, whereas anti-dystrophin and anti-beta1-dystroglycan clearly delineate the sarcolemma in myotubes [12].

Associations of Sgca with chemical compounds


Physical interactions of Sgca

  • The incorporation of alpha-SG into the sarcoglycan complex occurs at the final stage by interaction with gamma-SG [14].

Regulatory relationships of Sgca

  • Adhalin was specifically expressed in striated muscle cells and their immediate precursors, and absent in many other cell types [8].

Other interactions of Sgca


  1. Progressive muscular dystrophy in alpha-sarcoglycan-deficient mice. Duclos, F., Straub, V., Moore, S.A., Venzke, D.P., Hrstka, R.F., Crosbie, R.H., Durbeej, M., Lebakken, C.S., Ettinger, A.J., van der Meulen, J., Holt, K.H., Lim, L.E., Sanes, J.R., Davidson, B.L., Faulkner, J.A., Williamson, R., Campbell, K.P. J. Cell Biol. (1998) [Pubmed]
  2. Noninvasive monitoring of therapeutic gene transfer in animal models of muscular dystrophies. Bartoli, M., Poupiot, J., Goyenvalle, A., Perez, N., Garcia, L., Danos, O., Richard, I. Gene Ther. (2006) [Pubmed]
  3. Epsilon-sarcoglycan compensates for lack of alpha-sarcoglycan in a mouse model of limb-girdle muscular dystrophy. Imamura, M., Mochizuki, Y., Engvall, E., Takeda, S. Hum. Mol. Genet. (2005) [Pubmed]
  4. Ultrastructural localization of adhalin in normal murine skeletal myofiber. Wakayama, Y., Inoue, M., Murahashi, M., Shibuya, S., Jimi, T., Kojima, H., Oniki, H. Ann. Neurol. (1996) [Pubmed]
  5. Interactions between dystrophin glycoprotein complex proteins. Madhavan, R., Jarrett, H.W. Biochemistry (1995) [Pubmed]
  6. Deficiency of alpha-sarcoglycan differently affects fast- and slow-twitch skeletal muscles. Danieli-Betto, D., Esposito, A., Germinario, E., Sandonà, D., Martinello, T., Jakubiec-Puka, A., Biral, D., Betto, R. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2005) [Pubmed]
  7. The childhood muscular dystrophies: diseases sharing a common pathogenesis of membrane instability. Mendell, J.R., Sahenk, Z., Prior, T.W. J. Child Neurol. (1995) [Pubmed]
  8. Mouse adhalin: primary structure and expression during late stages of muscle differentiation in vitro. Liu, L., Vachon, P.H., Kuang, W., Xu, H., Wewer, U.M., Kylsten, P., Engvall, E. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  9. Partial characterization of the mouse alpha-sarcoglycan promoter and its responsiveness to MyoD. Delgado-Olguín, P., Recillas-Targa, F., Rosas-Vargas, H., Salamanca, F., Coral-Vázquez, R.M. Biochim. Biophys. Acta (2006) [Pubmed]
  10. Muscles of mice deficient in alpha-sarcoglycan maintain large masses and near control force values throughout the life span. Consolino, C.M., Duclos, F., Lee, J., Williamson, R.A., Campbell, K.P., Brooks, S.V. Physiol. Genomics (2005) [Pubmed]
  11. Calcium homeostasis and cell death in Sol8 dystrophin-deficient cell line in culture. Marchand, E., Constantin, B., Vandebrouck, C., Raymond, G., Cognard, C. Cell Calcium (2001) [Pubmed]
  12. Nitric oxide synthase (NOS) in mouse skeletal muscle development and differentiated myoblasts. Blottner, D., Lück, G. Cell Tissue Res. (1998) [Pubmed]
  13. Induction of dystrophin-associated proteins together with nicotinic acetylcholine receptors by denervation in the absence of dystrophin in skeletal muscles of mdx mice. Mitsui, T., Kawai, H., Kawajiri, M., Kunishige, M., Aki, K., Saito, S. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  14. Specific assembly pathway of sarcoglycans is dependent on beta- and delta-sarcoglycan. Shi, W., Chen, Z., Schottenfeld, J., Stahl, R.C., Kunkel, L.M., Chan, Y.M. Muscle Nerve (2004) [Pubmed]
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