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Gene Review

Son  -  Son DNA binding protein

Mus musculus

Synonyms: 2900011L12Rik, AA409051, AU067731, C81487, NRE-binding protein, ...
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Disease relevance of Son


High impact information on Son

  • The mammalian sos1 and sos2 genes encode highly homologous members of the Son-of-sevenless family of guanine nucleotide exchange factors [2].
  • Interestingly, however, CD40 engagement resulted in the phosphorylation of both extracellular signal-regulated protein kinase (ERK) and the Ras guanine nucleotide exchange factor, Son of sevenless [3].
  • Disassembly of Son-of-sevenless proteins from Grb2 during p21ras desensitization by insulin [4].
  • A fragment consisting of residues 584-1071 of the mouse Son-of-sevenless 1 (mSos1) protein was found to be sufficient for stimulation of the guanine nucleotide exchange of Ras in vitro, which defines the CDC25 homology (CDC25H) domain of mSos1 [5].
  • The solution structure of the pleckstrin homology (PH) domain of mouse Son-of-sevenless 1 (mSos1), a guanine nucleotide exchange factor for Ras, was determined by multidimensional NMR spectroscopy [6].

Biological context of Son

  • Here we describe the organization of the Son locus in the mouse genome [7].
  • In this unusually compact gene cluster, we have found overlap in the pattern of expression between Gart, Son, and Donson [7].
  • Here, we tested the hypothesis that these neurotoxic agents might induce cell death in our nigral dopaminergic cell line, SN4741 (Son et al. 1999) through a common molecular mechanism [8].

Associations of Son with chemical compounds


  1. The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development. Sibilia, M., Fleischmann, A., Behrens, A., Stingl, L., Carroll, J., Watt, F.M., Schlessinger, J., Wagner, E.F. Cell (2000) [Pubmed]
  2. Ras-guanine nucleotide exchange factor sos2 is dispensable for mouse growth and development. Esteban, L.M., Fernández-Medarde, A., López, E., Yienger, K., Guerrero, C., Ward, J.M., Tessarollo, L., Santos, E. Mol. Cell. Biol. (2000) [Pubmed]
  3. CD40 ligation results in protein kinase C-independent activation of ERK and JNK in resting murine splenic B cells. Li, Y.Y., Baccam, M., Waters, S.B., Pessin, J.E., Bishop, G.A., Koretzky, G.A. J. Immunol. (1996) [Pubmed]
  4. Disassembly of Son-of-sevenless proteins from Grb2 during p21ras desensitization by insulin. Cherniack, A.D., Klarlund, J.K., Conway, B.R., Czech, M.P. J. Biol. Chem. (1995) [Pubmed]
  5. Activation of Ras and its downstream extracellular signal-regulated protein kinases by the CDC25 homology domain of mouse Son-of-sevenless 1 (mSos1). Kim, J.H., Shirouzu, M., Kataoka, T., Bowtell, D., Yokoyama, S. Oncogene (1998) [Pubmed]
  6. The solution structure of the pleckstrin homology domain of mouse Son-of-sevenless 1 (mSos1). Koshiba, S., Kigawa, T., Kim, J.H., Shirouzu, M., Bowtell, D., Yokoyama, S. J. Mol. Biol. (1997) [Pubmed]
  7. Organization and conservation of the GART/SON/DONSON locus in mouse and human genomes. Wynn, S.L., Fisher, R.A., Pagel, C., Price, M., Liu, Q.Y., Khan, I.M., Zammit, P., Dadrah, K., Mazrani, W., Kessling, A., Lee, J.S., Buluwela, L. Genomics (2000) [Pubmed]
  8. Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism. Chun, H.S., Gibson, G.E., DeGiorgio, L.A., Zhang, H., Kidd, V.J., Son, J.H. J. Neurochem. (2001) [Pubmed]
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