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Gene Review

Tekt1  -  tektin 1

Mus musculus

Synonyms: MT14, Tektin-1
 
 
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High impact information on Tekt1

  • The haploid germ cell-specific Tektin-t protein is a member of the Tektin family of proteins that form filaments in flagellar, ciliary, and axonemal microtubules [1].
  • We report the first mammalian (murine testis) cDNA for tektin, a protein unique to cilia, flagella, and centrioles, which we have used to identify related proteins and genes in sensory tissues [2].
  • One male germ cell-specific mouse cDNA clone was found to be similar to tektin A1, a protein known to interact with the flagellar microtubules of sea urchin sperm [3].
  • We have now investigated the temporal and spatial expression of Tekt1 during mouse male germ cell development [4].
  • The spatial and temporal expression of Tekt1, a mouse tektin C homologue, during spermatogenesis suggest that it is involved in the development of the sperm tail basal body and axoneme [4].
 

Anatomical context of Tekt1

  • Together with other evidence, these results provide the first intraspecies evidence that Tekt1 is transiently associated with the centrosome, and indicates that Tekt1 is one of several tektins to participate in the nucleation of the flagellar axoneme of mature spermatozoa, perhaps being required to assemble the basal body [4].
  • Recently we described the sequence of the first mammalian tektin protein, Tekt1 (from mouse testis), which is most homologous with sea urchin tektin C [4].
 

Analytical, diagnostic and therapeutic context of Tekt1

  • Using the cDNA as a probe, we determined the onset, relative levels, and locations of tektin expression in mouse for several adult tissues and embryonic stages by Northern blot analysis and in situ hybridization [2].

References

  1. Mice deficient in the axonemal protein Tektin-t exhibit male infertility and immotile-cilium syndrome due to impaired inner arm dynein function. Tanaka, H., Iguchi, N., Toyama, Y., Kitamura, K., Takahashi, T., Kaseda, K., Maekawa, M., Nishimune, Y. Mol. Cell. Biol. (2004) [Pubmed]
  2. Expression of ciliary tektins in brain and sensory development. Norrander, J., Larsson, M., Ståhl, S., Höög, C., Linck, R. J. Neurosci. (1998) [Pubmed]
  3. Rapid cDNA sequencing in combination with RNA expression studies in mice identifies a large number of male germ cell-specific sequence tags. Yuan, L., Liu, J.G., Höög, C. Biol. Reprod. (1995) [Pubmed]
  4. The spatial and temporal expression of Tekt1, a mouse tektin C homologue, during spermatogenesis suggest that it is involved in the development of the sperm tail basal body and axoneme. Larsson, M., Norrander, J., Gräslund, S., Brundell, E., Linck, R., Ståhl, S., Höög, C. Eur. J. Cell Biol. (2000) [Pubmed]
 
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