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Gene Review

TEKT1  -  tektin 1

Homo sapiens

Synonyms: Tektin-1
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Disease relevance of TEKT1


High impact information on TEKT1

  • Monoclonal antibodies specific for each of the flagellar tektins were prepared and used to determine whether structures similar to tektin filaments are present in cells lacking cilia or flagella [2].
  • Cross-reactivity of antibodies specific for flagellar tektin and intermediate filament subunits [2].
  • The proline content correlates well with the fact that tektin filaments have twice as much alpha-helical content as tubulin [3].
  • With reverse-phase HPLC on a C18 column, using 6 M guanidine-HCl solubilization and a 0.1% trifluoroacetic acid/CH3CN gradient system (Stephens, R. E., 1984, J. Cell Biol. 90:37a [Abstr.]), the relatively less hydrophobic 51-kD tektin elutes at greater than 45% CH3CN, immediately followed by the 55-kD chain [3].
  • Localization of tektin filaments in microtubules of sea urchin sperm flagella by immunoelectron microscopy [4].

Biological context of TEKT1


Anatomical context of TEKT1


Associations of TEKT1 with chemical compounds


Other interactions of TEKT1


Analytical, diagnostic and therapeutic context of TEKT1

  • High resolution two-dimensional tryptic peptide mapping reveals 63-67% coincidence among peptides of the 51-kD tektin chain and its 47- and 55-kD counterparts, greater than 70% coincidence between the 47- and 55-kD tektins, but little obvious similarity to either alpha- or beta-tubulin [3].
  • Doublet microtubules were fractionated into tektin filaments and separated by SDS-PAGE into three major tektin polypeptide bands (Mr = 47, 51 and 55 (X 10(3)), which were used to immunize rabbits [14].
  • Antibodies against each tektin (anti-tektins) were affinity-purified and then characterized by two-dimensional isoelectric focusing/SDS-PAGE immunoblotting and by immunofluorescence microscopy [14].
  • Using a new antibody to tektin consensus peptide RPNVELCRD, well-characterized chain-specific antibodies and quantitative gel densitometry, tektins A, B and C were found to be present in equimolar amounts in Sarkosyl-urea-stable filaments [15].
  • Western blot immunological detection techniques (for tektin and centrin) and two-dimensional gel analysis (for calmodulin) were used [1].


  1. Search for eukaryotic motility proteins in spirochetes: immunological detection of a tektin-like protein in Spirochaeta halophila. Barth, A.L., Stricker, J.A., Margulis, L. BioSystems (1991) [Pubmed]
  2. Cross-reactivity of antibodies specific for flagellar tektin and intermediate filament subunits. Chang, X.J., Piperno, G. J. Cell Biol. (1987) [Pubmed]
  3. Biochemical characterization of tektins from sperm flagellar doublet microtubules. Linck, R.W., Stephens, R.E. J. Cell Biol. (1987) [Pubmed]
  4. Localization of tektin filaments in microtubules of sea urchin sperm flagella by immunoelectron microscopy. Linck, R.W., Amos, L.A., Amos, W.B. J. Cell Biol. (1985) [Pubmed]
  5. Cloning and characterization of a novel human TEKTIN1 gene. Xu, M., Zhou, Z., Cheng, C., Zhao, W., Tang, R., Huang, Y., Wang, W., Xu, J., Zeng, L., Xie, Y., Mao, Y. Int. J. Biochem. Cell Biol. (2001) [Pubmed]
  6. Cloning and characterization of the human tektin-t gene. Iguchi, N., Tanaka, H., Nakamura, Y., Nozaki, M., Fujiwara, T., Nishimune, Y. Mol. Hum. Reprod. (2002) [Pubmed]
  7. Transcriptional control of tektin A mRNA correlates with cilia development and length determination during sea urchin embryogenesis. Norrander, J.M., Linck, R.W., Stephens, R.E. Development (1995) [Pubmed]
  8. Tektin B1 from ciliary microtubules: primary structure as deduced from the cDNA sequence and comparison with tektin A1. Chen, R., Perrone, C.A., Amos, L.A., Linck, R.W. J. Cell. Sci. (1993) [Pubmed]
  9. Characterization of ciliated bronchial epithelium 1, a ciliated cell-associated gene induced during mucociliary differentiation. Yoshisue, H., Puddicombe, S.M., Wilson, S.J., Haitchi, H.M., Powell, R.M., Wilson, D.I., Pandit, A., Berger, A.E., Davies, D.E., Holgate, S.T., Holloway, J.W. Am. J. Respir. Cell Mol. Biol. (2004) [Pubmed]
  10. Structural comparison of tektins and evidence for their determination of complex spacings in flagellar microtubules. Norrander, J.M., Perrone, C.A., Amos, L.A., Linck, R.W. J. Mol. Biol. (1996) [Pubmed]
  11. Molecular cloning of haploid germ cell-specific tektin cDNA and analysis of the protein in mouse testis. Iguchi, N., Tanaka, H., Fujii, T., Tamura, K., Kaneko, Y., Nojima, H., Nishimune, Y. FEBS Lett. (1999) [Pubmed]
  12. Relationship between tektins and intermediate filament proteins: an immunological study. Steffen, W., Linck, R.W. Cell Motil. Cytoskeleton (1989) [Pubmed]
  13. At least one of the protofilaments in flagellar microtubules is not composed of tubulin. Nojima, D., Linck, R.W., Egelman, E.H. Curr. Biol. (1995) [Pubmed]
  14. Characterization of antibodies as probes for structural and biochemical studies of tektins from ciliary and flagellar microtubules. Linck, R.W., Goggin, M.J., Norrander, J.M., Steffen, W. J. Cell. Sci. (1987) [Pubmed]
  15. Tektin interactions and a model for molecular functions. Setter, P.W., Malvey-Dorn, E., Steffen, W., Stephens, R.E., Linck, R.W. Exp. Cell Res. (2006) [Pubmed]
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