Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Tgtp1 - T cell specific GTPase 1

Mus musculus

Synonyms: Gtp2, Irgb6, Mg21, Tgtp

Lafuse, W.P. et al., Carlow, D.A. et al., Hussain, S. et al., Carlow, D.A. et al.

Carlow, Teh, Teh,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Tgtp

Reduced expression of IFN-gamma-inducible genes-MHC class II gene E beta; MHC class II transactivator; IFN regulatory factor-1; and Mg21, a gene coding for a GTP-binding protein-was observed in M. avium-infected macrophages [1].
A new family of putative GTPases, including IRG-47, LRG-47, IGTP, and TGTP/Mg21, has recently emerged that share significant sequence identity (25-40%) [2].
In contrast, expression of Tgtp is peripheral T cells is maintained at relatively high levels and is not grossly affected by TCR cross-linking [3].
The only known relative of Tgtp is MUSGTP, which is reportedly expressed in B cells and bears a GTP binding motif [3].
In this study, we describe a novel full length cDNA clone designated Tgtp that encodes a predicted 415-amino acid a T cell-specific guanine nucleotide triphosphate-binding protein (TGTP) bearing the characteristic motifs of a guanine nucleotide triphosphate (GTP) binding protein [3].

Biological context of Tgtp

The DNA sequence of Mg21 is 1617 nucleotides and contains an open reading frame that codes for a protein of 415 amino acids with a predicted molecular weight of 47,106 Da [4].
Analysis of the protein sequence of Mg21 showed that these three conserved protein motifs are also present in Mg21 [4].

Anatomical context of Tgtp

We have isolated from this subtraction library a novel cDNA clone, called Mg21, whose mRNA is absent in unstimulated mouse peritoneal macrophages and is induced to high levels within 4 h following the addition of IFN-gamma [4].

Associations of Tgtp with chemical compounds

Induction of Mg21 mRNA by IFN-gamma occurred in the presence of cycloheximide, indicating that expression of Mg21 mRNA does not require protein synthesis [4].

References

Mycobacterium avium infection of mouse macrophages inhibits IFN-gamma Janus kinase-STAT signaling and gene induction by down-regulation of the IFN-gamma receptor. Hussain, S., Zwilling, B.S., Lafuse, W.P. J. Immunol. (1999) [Pubmed]
Specific antiviral activity demonstrated by TGTP, a member of a new family of interferon-induced GTPases. Carlow, D.A., Teh, S.J., Teh, H.S. J. Immunol. (1998) [Pubmed]
Isolation of a gene encoding a developmentally regulated T cell-specific protein with a guanine nucleotide triphosphate-binding motif. Carlow, D.A., Marth, J., Clark-Lewis, I., Teh, H.S. J. Immunol. (1995) [Pubmed]
Cloning and characterization of a novel cDNA that is IFN-gamma-induced in mouse peritoneal macrophages and encodes a putative GTP-binding protein. Lafuse, W.P., Brown, D., Castle, L., Zwilling, B.S. J. Leukoc. Biol. (1995) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.