Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Tlr6 - toll-like receptor 6

Mus musculus

Synonyms: Toll-like receptor 6

Diniz, S.N. et al., Soboll, G. et al., Takeuchi, O. et al.

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High impact information on Tlr6

Using fluorescein-activated cell sorter analysis and reverse transcriptase-polymerase chain reaction, we demonstrated that basal level of Toll-like receptor-6 and Zy-induced dectin-1 expression was slightly but consistently higher in macrophages from Tg mice than in macrophages from WT mice [1].
These results indicate that mRNAs for Tlr1 through Tlr6 are expressed by uterine epithelial cells and that treatment with specific TLR agonists alters the expression of key chemokines and proinflammatory cytokines that contribute to the defense of the uterus against potential pathogens [2].
RT-PCR analysis revealed that murine TLR6 is expressed predominantly in spleen, thymus, ovary and lung [3].

References

PTX3 function as an opsonin for the dectin-1-dependent internalization of zymosan by macrophages. Diniz, S.N., Nomizo, R., Cisalpino, P.S., Teixeira, M.M., Brown, G.D., Mantovani, A., Gordon, S., Reis, L.F., Dias, A.A. J. Leukoc. Biol. (2004) [Pubmed]
Expression of Toll-like receptors (TLR) and responsiveness to TLR agonists by polarized mouse uterine epithelial cells in culture. Soboll, G., Shen, L., Wira, C.R. Biol. Reprod. (2006) [Pubmed]
TLR6: A novel member of an expanding toll-like receptor family. Takeuchi, O., Kawai, T., Sanjo, H., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Takeda, K., Akira, S. Gene (1999) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

TLR6	Bos taurus
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TLR1LB	Gallus gallus
TLR1LA	Gallus gallus
TLR6	Homo sapiens
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Tlr6	Rattus norvegicus
LOC100493946	Xenopus (Silurana) tropicalis

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