The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

TLR6  -  toll-like receptor 6

Homo sapiens

Synonyms: CD286, Toll-like receptor 6
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of TLR6


High impact information on TLR6

  • Finally, we show that TLR6, TLR2, and TLR1 are recruited to macrophage phagosomes that contain IgG-coated erythrocytes that do not display microbial components [6].
  • TLR6 and TLR2 both are recruited to the macrophage phagosome, where they recognize peptidoglycan, a Gram-positive pathogen component [6].
  • In addition, unlike TLR1 and TLR6, TLR10 was expressed in a highly restricted fashion as a highly N-glycosylated protein, which we detected in B cell lines, B cells from peripheral blood, and plasmacytoid dendritic cells from tonsil [7].
  • Confocal microscopic analysis revealed that TLR6 was colocalized with TLR2 at the plasma membrane of monocytes [8].
  • However, response to protein I/II stimulation was independent of TLR4, TLR2, and TLR6 [9].
  • TLR6 has sense Alu elements in its 3'UTR region, making it susceptible to the regulation of other protein-coding or non-coding RNAs with antisense Alu elements [10].

Biological context of TLR6


Anatomical context of TLR6


Associations of TLR6 with chemical compounds


Other interactions of TLR6

  • TLR1 and TLR6 were expressed in all cell types examined [18].
  • TLR6 associates with TLR2 and recognizes diacylated mycoplasmal lipopeptide along with TLR2 [19].
  • Here we show that TLR6-deficient (TLR6(-/-)) cells are unresponsive to MALP-2 but retain their normal responses to lipopeptides of other bacterial origins [20].
  • Compared with wild-type cells, which produced large amounts of TNF-alpha after incubation with PLM, the deletion of the TLR4 and TLR6 genes led to a limited alteration of the PLM-induced response [21].

Analytical, diagnostic and therapeutic context of TLR6


  1. Toll-like receptors as sensors of pathogens. Hallman, M., Rämet, M., Ezekowitz, R.A. Pediatr. Res. (2001) [Pubmed]
  2. Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases. Pierik, M., Joossens, S., Van Steen, K., Van Schuerbeek, N., Vlietinck, R., Rutgeerts, P., Vermeire, S. Inflamm. Bowel Dis. (2006) [Pubmed]
  3. Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk. Sun, J., Wiklund, F., Zheng, S.L., Chang, B., Bälter, K., Li, L., Johansson, J.E., Li, G., Adami, H.O., Liu, W., Tolin, A., Turner, A.R., Meyers, D.A., Isaacs, W.B., Xu, J., Grönberg, H. J. Natl. Cancer Inst. (2005) [Pubmed]
  4. Role of lipoteichoic acid in the phagocyte response to group B streptococcus. Henneke, P., Morath, S., Uematsu, S., Weichert, S., Pfitzenmaier, M., Takeuchi, O., Müller, A., Poyart, C., Akira, S., Berner, R., Teti, G., Geyer, A., Hartung, T., Trieu-Cuot, P., Kasper, D.L., Golenbock, D.T. J. Immunol. (2005) [Pubmed]
  5. Porcine TLR2 and TLR6: identification and their involvement in Mycoplasma hyopneumoniae infection. Muneta, Y., Uenishi, H., Kikuma, R., Yoshihara, K., Shimoji, Y., Yamamoto, R., Hamashima, N., Yokomizo, Y., Mori, Y. J. Interferon Cytokine Res. (2003) [Pubmed]
  6. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Ozinsky, A., Underhill, D.M., Fontenot, J.D., Hajjar, A.M., Smith, K.D., Wilson, C.B., Schroeder, L., Aderem, A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  7. Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88. Hasan, U., Chaffois, C., Gaillard, C., Saulnier, V., Merck, E., Tancredi, S., Guiet, C., Brière, F., Vlach, J., Lebecque, S., Trinchieri, G., Bates, E.E. J. Immunol. (2005) [Pubmed]
  8. Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells. Nakao, Y., Funami, K., Kikkawa, S., Taniguchi, M., Nishiguchi, M., Fukumori, Y., Seya, T., Matsumoto, M. J. Immunol. (2005) [Pubmed]
  9. Cross talk between MyD88 and focal adhesion kinase pathways. Zeisel, M.B., Druet, V.A., Sibilia, J., Klein, J.P., Quesniaux, V., Wachsmann, D. J. Immunol. (2005) [Pubmed]
  10. A gene expression restriction network mediated by sense and antisense Alu sequences located on protein-coding messenger RNAs. Liang, K.H., Yeh, C.T. BMC. Genomics. (2013) [Pubmed]
  11. TLR6: A novel member of an expanding toll-like receptor family. Takeuchi, O., Kawai, T., Sanjo, H., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Takeda, K., Akira, S. Gene (1999) [Pubmed]
  12. Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma. Tantisira, K., Klimecki, W.T., Lazarus, R., Palmer, L.J., Raby, B.A., Kwiatkowski, D.J., Silverman, E., Vercelli, D., Martinez, F.D., Weiss, S.T. Genes Immun. (2004) [Pubmed]
  13. Macrophage-activating lipopeptide-2 induces cyclooxygenase-2 and prostaglandin E(2) via toll-like receptor 2 in human placental trophoblast cells. Mitsunari, M., Yoshida, S., Shoji, T., Tsukihara, S., Iwabe, T., Harada, T., Terakawa, N. J. Reprod. Immunol. (2006) [Pubmed]
  14. Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways. Henneke, P., Takeuchi, O., Malley, R., Lien, E., Ingalls, R.R., Freeman, M.W., Mayadas, T., Nizet, V., Akira, S., Kasper, D.L., Golenbock, D.T. J. Immunol. (2002) [Pubmed]
  15. Human intestinal epithelial cells are broadly unresponsive to Toll-like receptor 2-dependent bacterial ligands: implications for host-microbial interactions in the gut. Melmed, G., Thomas, L.S., Lee, N., Tesfay, S.Y., Lukasek, K., Michelsen, K.S., Zhou, Y., Hu, B., Arditi, M., Abreu, M.T. J. Immunol. (2003) [Pubmed]
  16. Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin. Hajjar, A.M., O'Mahony, D.S., Ozinsky, A., Underhill, D.M., Aderem, A., Klebanoff, S.J., Wilson, C.B. J. Immunol. (2001) [Pubmed]
  17. Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1. Lee, J.Y., Zhao, L., Youn, H.S., Weatherill, A.R., Tapping, R., Feng, L., Lee, W.H., Fitzgerald, K.A., Hwang, D.H. J. Biol. Chem. (2004) [Pubmed]
  18. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. Hornung, V., Rothenfusser, S., Britsch, S., Krug, A., Jahrsdörfer, B., Giese, T., Endres, S., Hartmann, G. J. Immunol. (2002) [Pubmed]
  19. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. Takeuchi, O., Sato, S., Horiuchi, T., Hoshino, K., Takeda, K., Dong, Z., Modlin, R.L., Akira, S. J. Immunol. (2002) [Pubmed]
  20. Discrimination of bacterial lipoproteins by Toll-like receptor 6. Takeuchi, O., Kawai, T., Mühlradt, P.F., Morr, M., Radolf, J.D., Zychlinsky, A., Takeda, K., Akira, S. Int. Immunol. (2001) [Pubmed]
  21. Candida albicans phospholipomannan is sensed through toll-like receptors. Jouault, T., Ibata-Ombetta, S., Takeuchi, O., Trinel, P.A., Sacchetti, P., Lefebvre, P., Akira, S., Poulain, D. J. Infect. Dis. (2003) [Pubmed]
  22. Expression of Toll-like receptors on human platelets. Shiraki, R., Inoue, N., Kawasaki, S., Takei, A., Kadotani, M., Ohnishi, Y., Ejiri, J., Kobayashi, S., Hirata, K., Kawashima, S., Yokoyama, M. Thromb. Res. (2004) [Pubmed]
  23. TLR1 and TLR6 Polymorphisms Are Associated with Susceptibility to Invasive Aspergillosis after Allogeneic Stem Cell Transplantation. Kesh, S., Mensah, N.Y., Peterlongo, P., Jaffe, D., Hsu, K., VAN DEN Brink, M., O'reilly, R., Pamer, E., Satagopan, J., Papanicolaou, G.A. Ann. N. Y. Acad. Sci. (2005) [Pubmed]
WikiGenes - Universities