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Gene Review

Clec7a  -  C-type lectin domain family 7, member a

Mus musculus

Synonyms: BGR, Beta-glucan receptor, Bgr, C-type lectin domain family 7 member A, C-type lectin superfamily member 12, ...
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Disease relevance of Clec7a


High impact information on Clec7a

  • Although beta-glucans are known to bind to receptors, such as complement receptor 3 (ref. 1), there is evidence that another beta-glucan receptor is present on macrophages [3].
  • Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins [4].
  • Our results establish a fundamental function for beta-glucan recognition by dectin-1 in antifungal immunity and demonstrate a signaling non-Toll-like pattern-recognition receptor required for the induction of protective immune responses [5].
  • Dectin-1-deficient leukocytes demonstrated significantly impaired responses to fungi even in the presence of opsonins [5].
  • Dectin-1 is a C-type lectin involved in the recognition of beta-glucans found in the cell walls of fungi [6].

Biological context of Clec7a


Anatomical context of Clec7a


Associations of Clec7a with chemical compounds


Physical interactions of Clec7a


Regulatory relationships of Clec7a


Other interactions of Clec7a


Analytical, diagnostic and therapeutic context of Clec7a


  1. The beta-glucan receptor dectin-1 functions together with TLR2 to mediate macrophage activation by mycobacteria. Yadav, M., Schorey, J.S. Blood (2006) [Pubmed]
  2. Normal host defense during systemic candidiasis in mannose receptor-deficient mice. Lee, S.J., Zheng, N.Y., Clavijo, M., Nussenzweig, M.C. Infect. Immun. (2003) [Pubmed]
  3. Immune recognition. A new receptor for beta-glucans. Brown, G.D., Gordon, S. Nature (2001) [Pubmed]
  4. Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Rogers, N.C., Slack, E.C., Edwards, A.D., Nolte, M.A., Schulz, O., Schweighoffer, E., Williams, D.L., Gordon, S., Tybulewicz, V.L., Brown, G.D., Reis e Sousa, C. Immunity (2005) [Pubmed]
  5. Dectin-1 is required for beta-glucan recognition and control of fungal infection. Taylor, P.R., Tsoni, S.V., Willment, J.A., Dennehy, K.M., Rosas, M., Findon, H., Haynes, K., Steele, C., Botto, M., Gordon, S., Brown, G.D. Nat. Immunol. (2007) [Pubmed]
  6. Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans. Saijo, S., Fujikado, N., Furuta, T., Chung, S.H., Kotaki, H., Seki, K., Sudo, K., Akira, S., Adachi, Y., Ohno, N., Kinjo, T., Nakamura, K., Kawakami, K., Iwakura, Y. Nat. Immunol. (2007) [Pubmed]
  7. Characterization of beta-glucan recognition site on C-type lectin, dectin 1. Adachi, Y., Ishii, T., Ikeda, Y., Hoshino, A., Tamura, H., Aketagawa, J., Tanaka, S., Ohno, N. Infect. Immun. (2004) [Pubmed]
  8. Dectin-1 is a major beta-glucan receptor on macrophages. Brown, G.D., Taylor, P.R., Reid, D.M., Willment, J.A., Williams, D.L., Martinez-Pomares, L., Wong, S.Y., Gordon, S. J. Exp. Med. (2002) [Pubmed]
  9. PTX3 function as an opsonin for the dectin-1-dependent internalization of zymosan by macrophages. Diniz, S.N., Nomizo, R., Cisalpino, P.S., Teixeira, M.M., Brown, G.D., Mantovani, A., Gordon, S., Reis, L.F., Dias, A.A. J. Leukoc. Biol. (2004) [Pubmed]
  10. Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and Dectin-1. Viriyakosol, S., Fierer, J., Brown, G.D., Kirkland, T.N. Infect. Immun. (2005) [Pubmed]
  11. Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages. Herre, J., Marshall, A.S., Caron, E., Edwards, A.D., Williams, D.L., Schweighoffer, E., Tybulewicz, V., Reis e Sousa, C., Gordon, S., Brown, G.D. Blood (2004) [Pubmed]
  12. The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages. Taylor, P.R., Brown, G.D., Herre, J., Williams, D.L., Willment, J.A., Gordon, S. J. Immunol. (2004) [Pubmed]
  13. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. Gantner, B.N., Simmons, R.M., Canavera, S.J., Akira, S., Underhill, D.M. J. Exp. Med. (2003) [Pubmed]
  14. Dectin-1 and its role in the recognition of beta-glucans by macrophages. Herre, J., Gordon, S., Brown, G.D. Mol. Immunol. (2004) [Pubmed]
  15. Beta-glucan activates microglia without inducing cytokine production in Dectin-1-dependent manner. Shah, V.B., Huang, Y., Keshwara, R., Ozment-Skelton, T., Williams, D.L., Keshvara, L. J. Immunol. (2008) [Pubmed]
  16. Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells. Xu, S., Huo, J., Lee, K.G., Kurosaki, T., Lam, K.P. J. Biol. Chem. (2009) [Pubmed]
  17. Interferon-gamma inhibits endocytosis of soluble animated beta-1,3-D-glucan and neutral red in mouse peritoneal macrophages. Konopski, Z., Fandrem, J., Seljelid, R., Eskeland, T. J. Interferon Cytokine Res. (1995) [Pubmed]
  18. Mechanism of Enhanced Hematopoietic Response by Soluble beta-Glucan SCG in Cyclophosphamide-Treated Mice. Harada, T., Kawaminami, H., Miura, N.N., Adachi, Y., Nakajima, M., Yadomae, T., Ohno, N. Microbiol. Immunol. (2006) [Pubmed]
  19. Dectin-1 expression and function are enhanced on alternatively activated and GM-CSF-treated macrophages and are negatively regulated by IL-10, dexamethasone, and lipopolysaccharide. Willment, J.A., Lin, H.H., Reid, D.M., Taylor, P.R., Williams, D.L., Wong, S.Y., Gordon, S., Brown, G.D. J. Immunol. (2003) [Pubmed]
  20. Limited contribution of Toll-like receptor 2 and 4 to the host response to a fungal infectious pathogen, Cryptococcus neoformans. Nakamura, K., Miyagi, K., Koguchi, Y., Kinjo, Y., Uezu, K., Kinjo, T., Akamine, M., Fujita, J., Kawamura, I., Mitsuyama, M., Adachi, Y., Ohno, N., Takeda, K., Akira, S., Miyazato, A., Kaku, M., Kawakami, K. FEMS Immunol. Med. Microbiol. (2006) [Pubmed]
  21. Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments. Gantner, B.N., Simmons, R.M., Underhill, D.M. EMBO J. (2005) [Pubmed]
  22. Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge. Rice, P.J., Adams, E.L., Ozment-Skelton, T., Gonzalez, A.J., Goldman, M.P., Lockhart, B.E., Barker, L.A., Breuel, K.F., Deponti, W.K., Kalbfleisch, J.H., Ensley, H.E., Brown, G.D., Gordon, S., Williams, D.L. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  23. Cytokines and PGE2 modulate the phagocytic function of the beta-glucan receptor in macrophages. Konopski, Z., Seljelid, R., Eskeland, T. Scand. J. Immunol. (1993) [Pubmed]
  24. Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Gross, O., Gewies, A., Finger, K., Schäfer, M., Sparwasser, T., Peschel, C., Förster, I., Ruland, J. Nature (2006) [Pubmed]
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