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Gene Review

ALDH1A3  -  aldehyde dehydrogenase 1 family, member A3

Homo sapiens

Synonyms: ALDH1A6, ALDH6, Aldehyde dehydrogenase 6, Aldehyde dehydrogenase family 1 member A3, MCOP8, ...
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High impact information on ALDH1A3

  • Retinoic acid biosynthesis by normal human breast epithelium is via aldehyde dehydrogenase 6, absent in MCF-7 cells [1].
  • Identification of ALDH6 as the retinaldehyde dehydrogenase present in normal human breast epithelia provides the first tool necessary for studying the loss of RA synthetic ability in cancer cells and the relationship of this process to malignant transformation [1].
  • When MCF-7 cells were then transfected with ALDH6, they (re)gained the ability to oxidize retinal to RA as well as some ability to synthesize RA when provided with retinol [1].
  • During the first postnatal week, the RALDH3-expressing territory translocates in the caudal cortex from the medial limbic lobe to the adjacent neocortex [2].
  • In this paper, we describe the cloning, characterization, and chromosomal mapping of an aldehyde dehydrogenase gene (ALDH6) expressed in the human salivary gland [3].

Biological context of ALDH1A3


Other interactions of ALDH1A3

  • Furthermore, marker D15S642, not far from the ALDH6 gene, provided an MC p-value of 0.0005 in ethnic groups "White, Hispanic" and "White, non-Hispanic."[4]

Analytical, diagnostic and therapeutic context of ALDH1A3


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