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Gene Review

Yap1  -  yes-associated protein 1

Mus musculus

Synonyms: AI325207, Protein yorkie homolog, Transcriptional coactivator YAP1, Yap, Yap65, ...
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High impact information on Yap1

  • Gene-expression analyses delineated cIAP1, a known inhibitor of apoptosis, and Yap, a transcription factor, as candidate oncogenes in the amplicon [1].
  • The mouse amplicon contains only one known gene, Yap, encoding the mammalian ortholog of Drosophila Yorkie (Yki), a downstream effector of the Hippo(Hpo)-Salvador(Sav)-Warts(Wts) signaling cascade, recently identified in flies as a critical regulator of cellular proliferation and apoptosis [2].
  • Nonetheless, development of an organized yolk sac vascular plexus failed in Yap-/- embryos [3].
  • Teads and their co-factor YAP65 activated the CE in P19 cells, and binding of Tead to CE was essential for enhancer activity [4].
  • NES consisted of a leucine-rich stretch and two cysteines with a limited similarity to Yap/Pap-type NES [5].

Biological context of Yap1


Anatomical context of Yap1

  • The association of Smad7 with YAP65 was confirmed using co-expressed tagged proteins in COS-7 cells [7].

Associations of Yap1 with chemical compounds

  • However, aqueous extracts of Stylotella aurantium and Axinella carteri collected in Yap State, Micronesia, afforded a known N-methyl-d-aspartic acid (NMDA)-type glutamate receptor agonist, (2S,4S)-4-sulfooxypiperidine-2-carboxylic acid (2), as a common active principle [8].


  1. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Zender, L., Spector, M.S., Xue, W., Flemming, P., Cordon-Cardo, C., Silke, J., Fan, S.T., Luk, J.M., Wigler, M., Hannon, G.J., Mu, D., Lucito, R., Powers, S., Lowe, S.W. Cell (2006) [Pubmed]
  2. Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Overholtzer, M., Zhang, J., Smolen, G.A., Muir, B., Li, W., Sgroi, D.C., Deng, C.X., Brugge, J.S., Haber, D.A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65. Morin-Kensicki, E.M., Boone, B.N., Howell, M., Stonebraker, J.R., Teed, J., Alb, J.G., Magnuson, T.R., O'Neal, W., Milgram, S.L. Mol. Cell. Biol. (2006) [Pubmed]
  4. Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor. Sawada, A., Nishizaki, Y., Sato, H., Yada, Y., Nakayama, R., Yamamoto, S., Nishioka, N., Kondoh, H., Sasaki, H. Development (2005) [Pubmed]
  5. Hic-5 communicates between focal adhesions and the nucleus through oxidant-sensitive nuclear export signal. Shibanuma, M., Kim-Kaneyama, J.R., Ishino, K., Sakamoto, N., Hishiki, T., Yamaguchi, K., Mori, K., Mashimo, J., Nose, K. Mol. Biol. Cell (2003) [Pubmed]
  6. WWP, a new amino acid motif present in single or multiple copies in various proteins including dystrophin and the SH3-binding Yes-associated protein YAP65. André, B., Springael, J.Y. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  7. Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling. Ferrigno, O., Lallemand, F., Verrecchia, F., L'Hoste, S., Camonis, J., Atfi, A., Mauviel, A. Oncogene (2002) [Pubmed]
  8. Isolations of N-methyl-D-aspartic acid-type glutamate receptor ligands from Micronesian sponges. Sakai, R., Matsubara, H., Shimamoto, K., Jimbo, M., Kamiya, H., Namikoshi, M. J. Nat. Prod. (2003) [Pubmed]
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