High impact information on Yap1

• Gene-expression analyses delineated cIAP1, a known inhibitor of apoptosis, and Yap, a transcription factor, as candidate oncogenes in the amplicon [1].
• The mouse amplicon contains only one known gene, Yap, encoding the mammalian ortholog of Drosophila Yorkie (Yki), a downstream effector of the Hippo(Hpo)-Salvador(Sav)-Warts(Wts) signaling cascade, recently identified in flies as a critical regulator of cellular proliferation and apoptosis [2].
• Nonetheless, development of an organized yolk sac vascular plexus failed in Yap-/- embryos [3].
• Teads and their co-factor YAP65 activated the CE in P19 cells, and binding of Tead to CE was essential for enhancer activity [4].
• NES consisted of a leucine-rich stretch and two cysteines with a limited similarity to Yap/Pap-type NES [5].

Biological context of Yap1

• WWP, a new amino acid motif present in single or multiple copies in various proteins including dystrophin and the SH3-binding Yes-associated protein YAP65 [6].

Anatomical context of Yap1

• The association of Smad7 with YAP65 was confirmed using co-expressed tagged proteins in COS-7 cells [7].

Associations of Yap1 with chemical compounds

• However, aqueous extracts of Stylotella aurantium and Axinella carteri collected in Yap State, Micronesia, afforded a known N-methyl-d-aspartic acid (NMDA)-type glutamate receptor agonist, (2S,4S)-4-sulfooxypiperidine-2-carboxylic acid (2), as a common active principle [8].

References