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Gene Review

Mkrn3  -  makorin, ring finger protein, 3

Mus musculus

Synonyms: D7H15S9-1, Zfp127, Zinc finger protein 127, Znf127
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Disease relevance of Mkrn3


High impact information on Mkrn3

  • On the other hand, the Zfp127/Snrpn locus showed such an allele-specific fractionation pattern only in F(1) hybrid mice of a cross but not in those of the reciprocal cross [2].
  • We hypothesize that the gametic imprint may be set, at least in part, by the transcriptional activity of Zfp127 in pre- and post-meiotic male germ cells [3].
  • Therefore, Zfp127 is a novel imprinted gene that may play a role in the imprinted phenotype of mouse models of PWS [3].
  • By the use of RT-PCR across an in-frame hexamer tandem repeat and RNA from a Mus musculus x M.spretus F1interspecific cross, we show that Zfp127 is expressed only from the paternal allele in brain, heart and kidney [3].
  • Here, we show that the mouse ZNF127 ortholog, Zfp127, encodes a homologous putative zinc-finger polypeptide, with a RING (C3HC4) and three C3H zinc-finger domains that suggest function as a ribonucleoprotein [3].

Biological context of Mkrn3


Anatomical context of Mkrn3

  • Similarly, Zfp127 is expressed in differentiated cells derived from androgenetic embryonic stem cells and normal embryos but not those from parthogenetic embryonic stem cells [3].

Other interactions of Mkrn3

  • A linear deletion map of the [Myod1, Ldh3]-[Snrpn, Znf127] region has been constructed from the molecular analyses of the p-locus deletions [5].


  1. Paternal expression of a novel imprinted gene, Peg12/Frat3, in the mouse 7C region homologous to the Prader-Willi syndrome region. Kobayashi, S., Kohda, T., Ichikawa, H., Ogura, A., Ohki, M., Kaneko-Ishino, T., Ishino, F. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  2. Differential chromatin packaging of genomic imprinted regions between expressed and non-expressed alleles. Watanabe, T., Yoshimura, A., Mishima, Y., Endo, Y., Shiroishi, T., Koide, T., Sasaki, H., Asakura, H., Kominami, R. Hum. Mol. Genet. (2000) [Pubmed]
  3. Imprinting of a RING zinc-finger encoding gene in the mouse chromosome region homologous to the Prader-Willi syndrome genetic region. Jong, M.T., Carey, A.H., Caldwell, K.A., Lau, M.H., Handel, M.A., Driscoll, D.J., Stewart, C.L., Rinchik, E.M., Nicholls, R.D. Hum. Mol. Genet. (1999) [Pubmed]
  4. Imprinted methylation and its effect on expression of the mouse Zfp127 gene. Hershko, A., Razin, A., Shemer, R. Gene (1999) [Pubmed]
  5. Molecular analysis of 36 mutations at the mouse pink-eyed dilution (p) locus. Johnson, D.K., Stubbs, L.J., Culiat, C.T., Montgomery, C.S., Russell, L.B., Rinchik, E.M. Genetics (1995) [Pubmed]
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