Gene Review:
CRTC2 - CREB regulated transcription coactivator 2
Homo sapiens
Synonyms:
CREB-regulated transcription coactivator 2, TORC-2, TORC2, Transducer of CREB protein 2, Transducer of regulated cAMP response element-binding protein 2
- Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth. Hietakangas, V., Cohen, S.M. Genes Dev. (2007)
- TOR signaling in growth and metabolism. Wullschleger, S., Loewith, R., Hall, M.N. Cell (2006)
- SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity. Jacinto, E., Facchinetti, V., Liu, D., Soto, N., Wei, S., Jung, S.Y., Huang, Q., Qin, J., Su, B. Cell (2006)
- The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Screaton, R.A., Conkright, M.D., Katoh, Y., Best, J.L., Canettieri, G., Jeffries, S., Guzman, E., Niessen, S., Yates, J.R., Takemori, H., Okamoto, M., Montminy, M. Cell (2004)
- TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats. Siu, Y.T., Chin, K.T., Siu, K.L., Yee Wai Choy, E., Jeang, K.T., Jin, D.Y. J. Virol. (2006)
- Cell growth control: little eukaryotes make big contributions. De Virgilio, C., Loewith, R. Oncogene (2006)
- Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling. Canettieri, G., Koo, S.H., Berdeaux, R., Heredia, J., Hedrick, S., Zhang, X., Montminy, M. Cell metabolism. (2005)
- Complexity of the TOR signaling network. Inoki, K., Guan, K.L. Trends Cell Biol. (2006)
- TORC2, a coactivator of cAMP-response element-binding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein. Murata, T., Sato, Y., Nakayama, S., Kudoh, A., Iwahori, S., Isomura, H., Tajima, M., Hishiki, T., Ohshima, T., Hijikata, M., Shimotohno, K., Tsurumi, T. J. Biol. Chem. (2009)