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Gene Review:

BICD2 - bicaudal D homolog 2 (Drosophila)

Homo sapiens

Synonyms: Bic-D 2, KIAA0699, Protein bicaudal D homolog 2, SMALED2, bA526D8.1

Hoogenraad, C.C. et al., Holland, P.M. et al., Hoogenraad, C.C. et al., Matanis, T. et al.

Holland, Milne, Garka, Johnson, Willis, Sims, Rauch, Bird, Virca,

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High impact information on BICD2

BICD1 and BICD2 colocalize with Rab6a on the trans-Golgi network (TGN) and on cytoplasmic vesicles, and associate with Golgi membranes in a Rab6-dependent manner [1].
Here we report that the N-terminal portion of human Bicaudal D2 (BICD2) is capable of inducing microtubule minus end-directed movement independently of the molecular context [2].
Here, we use the BICD2 N-terminal domain as a chimera with mitochondria and peroxisome-anchoring sequences to demonstrate the rapid dynein-mediated transport of selected organelles [2].
In interphase cells, BICD2 mainly localizes to the Golgi complex and has properties of a peripheral coat protein, yet it also co-localizes with dynactin at microtubule plus ends [3].
This may be indicative of a role for Nek8 and Bicd2 associated with cell cycle independent microtubule dynamics [4].

Biological context of BICD2

Treatment of cells with nocodazole leads to dramatic reorganization of Bicd2, and correlates with Nek8 phosphorylation [4].

References

Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. Matanis, T., Akhmanova, A., Wulf, P., Del Nery, E., Weide, T., Stepanova, T., Galjart, N., Grosveld, F., Goud, B., De Zeeuw, C.I., Barnekow, A., Hoogenraad, C.C. Nat. Cell Biol. (2002) [Pubmed]
Bicaudal D induces selective dynein-mediated microtubule minus end-directed transport. Hoogenraad, C.C., Wulf, P., Schiefermeier, N., Stepanova, T., Galjart, N., Small, J.V., Grosveld, F., de Zeeuw, C.I., Akhmanova, A. EMBO J. (2003) [Pubmed]
Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes. Hoogenraad, C.C., Akhmanova, A., Howell, S.A., Dortland, B.R., De Zeeuw, C.I., Willemsen, R., Visser, P., Grosveld, F., Galjart, N. EMBO J. (2001) [Pubmed]
Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2. Holland, P.M., Milne, A., Garka, K., Johnson, R.S., Willis, C., Sims, J.E., Rauch, C.T., Bird, T.A., Virca, G.D. J. Biol. Chem. (2002) [Pubmed]

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