High impact information on TENC1

• Thus, we have named the protein C1 domain-containing phosphatase and TENsin homologue (C1-TEN) [1].
• (2) With the stimulator working on the same wrist as for TNS-1, the loading time of the opposite wrist was determined (TNS-2) [2].
• In conclusion, C1-TEN appears to be a novel intracellular phosphatase that negatively regulates the Akt/PKB signaling cascade, and is similar to its relative PTEN in this respect [3].
• In addition, C1-TEN-overexpressing cells showed a markedly reduced phosphorylation of Akt/PKB kinase and its substrate GSK3, as well as reduced Akt enzymatic activity [3].
• C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration [3].

Biological context of TENC1

• Furthermore, serum starvation-induced apoptosis caused a twofold increase in caspase 3 activity in C1-TEN-overexpressing cells vs. mock cells [3].
• Furthermore, cells expressing a C1-TEN mutant where the putative phosphatase active site cysteine at position 231 was substituted for a serine displayed full restoration of both cell proliferation and Akt activation [3].

Analytical, diagnostic and therapeutic context of TENC1

• Northern blot analysis of C1-TEN in human tissues revealed highest expression in heart, kidney, and liver [1].

References