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Gene Review

LARS2  -  leucyl-tRNA synthetase 2, mitochondrial

Homo sapiens

Synonyms: KIAA0028, LEURS, LeuRS, Leucyl-tRNA synthetase, MGC26121, ...
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Disease relevance of LARS2

  • In striking contrast, deletion of the corresponding C-terminal domain of Escherichia coli LeuRS abolished aminoacylation of tRNALeu and also amino acid editing of mischarged tRNA molecules [1].
  • The famous Swiss physician of the eighteenth century, Samuel Auguste André David Tissot, devoted an 83-page chapter to migraine in his Traité des nerfs et de leurs maladies (Treatise on the nerves and nervous disorders) [2].

Psychiatry related information on LARS2

  • Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia [3].
  • Les participants attribuent leur contamination à des causes biologiques, morales ou sociales, et aux dimensions physiques, financières et relationnelles de leurs vies qui ont subi l'impact de l'infection [4].

High impact information on LARS2


Associations of LARS2 with chemical compounds

  • Previously, we have shown that asparagine207 in the fifth transmembrane domain of the histamine H1 receptor is crucial for the binding of the N tau-nitrogen of the imidazole ring of histamine (Leurs et al., Biochem. Biophys. Res. Commun., 201, 295, 1994) [6].
  • En se basant sur une ??tude qualitative des exp??riences des Chinois vivant avec le VIH/sida, cet article explore les processus complexes selon lesquels les hommes qui ont des rapports avec des hommes luttent et n??gocient avec leur sexualit??, leurs obligations familiales et cette maladie [7].

Other interactions of LARS2

  • We found that the freestanding LeuRS editing domain can edit this precursor in contrast to IleRS and ValRS editing domains [8].


  1. Functional divergence of a unique c-terminal domain of leucyl-tRNA synthetase to accommodate its splicing and aminoacylation roles. Hsu, J.L., Rho, S.B., Vannella, K.M., Martinis, S.A. J. Biol. Chem. (2006) [Pubmed]
  2. Samuel Auguste Tissot (1728-1797). His research on migraine. Karbowski, K. J. Neurol. (1986) [Pubmed]
  3. Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia. Munakata, K., Iwamoto, K., Bundo, M., Kato, T. Biol. Psychiatry (2005) [Pubmed]
  4. Living with HIV infection: Perceptions of patients with access to care at a non-governmental organization in Chennai, India. Tarakeshwar, N., Krishnan, A.K., Johnson, S., Solomon, S., Sikkema, K., Merson, M. Culture, health & sexuality. (2006) [Pubmed]
  5. Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene. 't Hart, L.M., Hansen, T., Rietveld, I., Dekker, J.M., Nijpels, G., Janssen, G.M., Arp, P.A., Uitterlinden, A.G., Jørgensen, T., Borch-Johnsen, K., Pols, H.A., Pedersen, O., van Duijn, C.M., Heine, R.J., Maassen, J.A. Diabetes (2005) [Pubmed]
  6. Lysine200 located in the fifth transmembrane domain of the histamine H1 receptor interacts with histamine but not with all H1 agonists. Leurs, R., Smit, M.J., Meeder, R., Ter Laak, A.M., Timmerman, H. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  7. Homosexuality, seropositivity, and family obligations: Perspectives of HIV-infected men who have sex with men in China. Zhou, Y.R. Culture, health & sexuality. (2006) [Pubmed]
  8. A present-day aminoacyl-tRNA synthetase with ancestral editing properties. Zhu, B., Zhao, M.W., Eriani, G., Wang, E.D. RNA (2007) [Pubmed]
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