Disease relevance of LARS2

• In striking contrast, deletion of the corresponding C-terminal domain of Escherichia coli LeuRS abolished aminoacylation of tRNALeu and also amino acid editing of mischarged tRNA molecules [1].
• The famous Swiss physician of the eighteenth century, Samuel Auguste André David Tissot, devoted an 83-page chapter to migraine in his Traité des nerfs et de leurs maladies (Treatise on the nerves and nervous disorders) [2].

Psychiatry related information on LARS2

• Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia [3].
• Les participants attribuent leur contamination à des causes biologiques, morales ou sociales, et aux dimensions physiques, financières et relationnelles de leurs vies qui ont subi l'impact de l'infection [4].

High impact information on LARS2

• Leucyl-tRNA synthetase (LeuRS) performs dual essential roles in group I intron RNA splicing as well as protein synthesis within the yeast mitochondria [1].
• In this study, we have examined whether variants in the leucyl tRNA synthetase gene (LARS2), involved in aminoacylation of tRNA(Leu(UUR)), associate with type 2 diabetes [5].
• Direct sequencing of LARS2 cDNA from 25 type 2 diabetic subjects revealed eight single nucleotide polymorphisms [5].
• CONCLUSIONS: These results suggest that upregulation of LARS2 is a hallmark of 324A>G mutation [3].
• These patients also showed higher levels of the mutation in their livers and significantly higher gene expression of LARS2 compared with other subjects [3].

Associations of LARS2 with chemical compounds

• Previously, we have shown that asparagine207 in the fifth transmembrane domain of the histamine H1 receptor is crucial for the binding of the N tau-nitrogen of the imidazole ring of histamine (Leurs et al., Biochem. Biophys. Res. Commun., 201, 295, 1994) [6].
• En se basant sur une ??tude qualitative des exp??riences des Chinois vivant avec le VIH/sida, cet article explore les processus complexes selon lesquels les hommes qui ont des rapports avec des hommes luttent et n??gocient avec leur sexualit??, leurs obligations familiales et cette maladie [7].

Other interactions of LARS2

• We found that the freestanding LeuRS editing domain can edit this precursor in contrast to IleRS and ValRS editing domains [8].

References