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Disease relevance of Morale

  • Re: Ebert T, Jockenhövel F, Morales A, Shabsigh R. The current status of therapy for symptomatic late onset hypogonadism with transdermal testosterone gel. Eur Urol 2005;47:137-46 [1].

High impact information on Morale

  • Specific ribonucleoprotein (RNP) complexes which form in vitro with gRNAs (H. U. Göringer, D. J. Koslowsky, T. H. Morales, and K. D. Stuart, Proc. Natl. Acad. Sci. USA, in press) are potential editosomes or their precursors [2].
  • These data provide additional support for the suggestion (e.g., del Castillo, J., W.C. deMello, and T. Morales (1963) Experientia 20: 141) that acetylcholine is an excitatory neurotransmitter at nematode neuromuscular junctions [3].
  • We have recently shown (Morales, O., Lindgren, U., and Haldosen, L. A. (2000) J. Bone Miner. Res. 15, 2284-2290) that UMR 106 cells express a GH-responsive JAK2/STAT5 signaling system [4].
  • In a previous study, we examined the role of lipid modifications in maintaining the membrane attachment of a G protein alpha subunit, alphaz, which is myristoylated and palmitoylated (Morales, J., Fishburn, C. S., Wilson, P. T., and Bourne, H. R. (1998) Mol. Biol. Cell 9, 1-14) [5].
  • Since its Km for actin is similar to that of tryptic SF1(A2), it may be concluded that changes in the affinity of SF1 for actin induced by trypsin [Botts, J., Muhlrad, A., Takashi, R., & Morales, M. F. (1982) Biochemistry 21, 6903-6905] are not dependent on the presence of the associated alkali light chain [6].

Chemical compound and disease context of Morale

  • Testosterone therapy in these men can significantly improve their sense of well-being, and lead to increases in muscle and bone mass, upper body strength, virility and libido [Gruenewald, Matsumoto. J Am Geriatr Soc 2003;51:101; Morales. Aging Male 2004; in press] [7].
  • We recently showed that over 70% of these c-Fos immunoreactive neurons are GABAergic [M. Morales, J.R. Criado, P.P. Sanna, S.J. Henriksen, F.E. Bloom, Acute ethanol induces c-fos immunoreactivity in GABAergic neurons of the central nucleus of the amygdala, Brain Res, 798 (1998) 333-336] [8].
  • Since 1976, when Morales, Eidinger and Bruce first published on the treatment of human urothelial bladder cancer, bacillus Calmette-Guérin has gained worldwide acceptance as a therapy against bladder carcinoma recurrences [9].
  • Cadmium concentrations were also higher in Morales [10].
  • Re: Morales, FJ, Montemayor T, Martínez A. Shuttle versus six-minute walk test in the prediction of outcome in chronic heart failure. Int J Cardiol 2000;76: 101-105 [11].

Biological context of Morale


Anatomical context of Morale

  • As previously reported for the mRNAs of transition protein 1 and protamine 1 [Morales et al., J Cell Sci 1991; 100:119-131], no compartmentalization of poly(A)+ RNAs was detected in the cytoplasm of round and elongated spermatids [13].
  • This technique has been utilized to quantify the amount of transferrin and SGP-2 mRNA present in Sertoli cells associated with different stages of the cycle of the seminiferous epithelium and to establish positively the Sertoli cell location of a specific mRNA (Morales et al. 1987) [14].

Gene context of Morale

  • Lutzomyia youngi Feliciangelis and Murillo and L. spinicrassa Morales, Osorno, Osorno, and Hoyos each have diagnostic allomorphs for phosphogluconate dehydrogenase (6PGDH) and fumarate hydratase (FUM) [15].
  • Data from these enzymes and glucose phosphate isomerase will separate L. townsendi (Ortiz) from the others and from L. longiflocosa Osorno, Morales, Osorno, and Hoyos, L. quasitownsendi Morales, Osorno, Osorno, and Hoyos, and L. sauroida Osorno, Morales, and Osorno (three species that are inseparable using enzyme data) [15].
  • Although DNA polymerase fidelity has been mainly ascribed to Watson-Crick hydrogen bonds, two nonpolar isosteres for thymine (T) and adenine (A)--difluorotoluene (F) and benzimidazole (Z) --effectively mimic their natural counterparts in polymerization experiments with pol I (KF exo-) [JC Morales and ET Kool. Nature Struct Biol, 5, 950-954, 1998] [16].
  • In order to establish the quality of the estimation process, we obtained the confidence intervals as a particularization of the functional (h-phi)-entropies proposed in [M. Salicru, M.L. Menendez, D. Morales, L. Pardo, Asymptotic distribution of (h,phi)-entropies, Commun. Stat. (Theory Methods) 22 (7) (1993) 2015] [17].
  • METHODS: Review of 40 years of published health studies of the BFD-endemic area of SW Taiwan showed that earlier publications had limited their cancer associations with arsenic levels in artesian well waters and that the reports of Morales et al., NRC, and EPA failed to do so [18].


  1. Re: Ebert T, Jockenhövel F, Morales A, Shabsigh R. The current status of therapy for symptomatic late onset hypogonadism with transdermal testosterone gel. Eur Urol 2005;47:137-46. Ponholzer, A., Rauchenwald, M., Madersbacher, S. Eur. Urol. (2005) [Pubmed]
  2. Assembly of mitochondrial ribonucleoprotein complexes involves specific guide RNA (gRNA)-binding proteins and gRNA domains but does not require preedited mRNA. Read, L.K., Göringer, H.U., Stuart, K. Mol. Cell. Biol. (1994) [Pubmed]
  3. Localization of choline acetyltransferase within identified motoneurons of the nematode Ascaris. Johnson, C.D., Stretton, A.O. J. Neurosci. (1985) [Pubmed]
  4. 1Alpha,25-dihydroxyvitamin D3 inhibits GH-induced expression of SOCS-3 and CIS and prolongs growth hormone signaling via the Janus kinase (JAK2)/signal transducers and activators of transcription (STAT5) system in osteoblast-like cells. Morales, O., Faulds, M.H., Lindgren, U.J., Haldosén, L.A. J. Biol. Chem. (2002) [Pubmed]
  5. Gbetagamma and palmitate target newly synthesized Galphaz to the plasma membrane. Fishburn, C.S., Herzmark, P., Morales, J., Bourne, H.R. J. Biol. Chem. (1999) [Pubmed]
  6. Effect of tryptic cleavage on the stability of myosin subfragment 1. Isolation and properties of the severed heavy-chain subunit. Burke, M., Kamalakannan, V. Biochemistry (1985) [Pubmed]
  7. The current status of therapy for symptomatic late-onset hypogonadism with transdermal testosterone gel. Ebert, T., Jockenhövel, F., Morales, A., Shabsigh, R. Eur. Urol. (2005) [Pubmed]
  8. Acute ethanol induction of c-Fos immunoreactivity in pre-pro-enkephalin expressing neurons of the central nucleus of the amygdala. Criado, J.R., Morales, M. Brain Res. (2000) [Pubmed]
  9. Prospects for improving the efficacy of BCG. Böhle, A. Eur. Urol. (1992) [Pubmed]
  10. Arsenic and cadmium exposure in children living near a smelter complex in San Luis Potosí, Mexico. Díaz-Barriga, F., Santos, M.A., Mejía, J.J., Batres, L., Yáñez, L., Carrizales, L., Vera, E., del Razo, L.M., Cebrián, M.E. Environmental research. (1993) [Pubmed]
  11. Re: Morales, FJ, Montemayor T, Martínez A. Shuttle versus six-minute walk test in the prediction of outcome in chronic heart failure. Int J Cardiol 2000;76: 101-105. Scott, A.C. International journal of cardiology. (2001) [Pubmed]
  12. Transforming growth factor-beta and insulin-like growth factor-1 restore proteoglycan metabolism of bovine articular cartilage after depletion by retinoic acid. Morales, T.I. Arch. Biochem. Biophys. (1994) [Pubmed]
  13. Poly(A)+ ribonucleic acids are enriched in spermatocyte nuclei but not in chromatoid bodies in the rat testis. Morales, C.R., Hecht, N.B. Biol. Reprod. (1994) [Pubmed]
  14. Molecular biology of the Sertoli cell. Griswold, M.D., Morales, C., Sylvester, S.R. Oxford reviews of reproductive biology. (1988) [Pubmed]
  15. Genetic relationships among phlebotomine sand flies (Diptera: Psychodidae) in the verrucarum species group. Kreutzer, R.D., Palau, M.T., Morales, A., Ferro, C., Feliciangeli, D., Young, D.G. J. Med. Entomol. (1990) [Pubmed]
  16. Interaction and solvation energies of nonpolar DNA base analogues and their role in polymerase insertion fidelity. Barsky, D., Kool, E.T., Colvin, M.E. J. Biomol. Struct. Dyn. (1999) [Pubmed]
  17. Accuracy in the estimation of quantitative minimal area from the diversity/area curve. Vives, S., Salicrú, M. Mathematical biosciences. (2005) [Pubmed]
  18. Bladder cancer and arsenic exposure: differences in the two populations enrolled in a study in southwest Taiwan. Lamm, S.H., Byrd, D.M., Kruse, M.B., Feinleib, M., Lai, S.H. Biomed. Environ. Sci. (2003) [Pubmed]
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