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Chemical Compound Review

Freedom     2-chloro-N-(2,6- diethylphenyl)-N...

Synonyms: Cannon, AC1MHFX8, LS-8484, 67022-32-6, Alachlor-trifluralin mixt, ...
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Disease relevance of Alachlor plus trifluralin

  • We have previously identified a residue in the carboxyl terminus of human immunodeficiency virus type 1 integrase (HIV-1 IN), W-235, the requirement for which is only revealed in viral assays for integrase function (P. M. Cannon, W. Wilson, E. Byles, S. M. Kingsman, and A. J. Kingsman, J. Virol. 68:4768-4775, 1994) [1].
  • RESULTS: Freedom from bronchiolitis obliterans syndrome (BOS) at three years was similar in those undergoing a virtual crossmatch, those undergoing prospective crossmatching, and those without HLA-specific antibodies (80.4% +/- 13.4, 85.7% +/- 13.2, and 73.8% +/- 2.8, respectively, P = 0.88) [2].
  • Commentary: Ch'ien LT, Cannon NJ, Charamella LJ, et al. effect of adenine arabinoside on severe herpesvirus hominis infections in man: preliminary report. J Infect Dis 1973; 128:658-63 [3].
  • Paclitaxel-based three-drug combinations for the treatment of small cell lung cancer: a review of the Sarah Cannon Cancer Center experience [4].
  • BACKGROUND: Freedom from migration is key to the durability of endovascular aneurysm repair (EVAR) [5].

Psychiatry related information on Alachlor plus trifluralin

  • Reports from the surgeon general and the President's New Freedom Commission on Mental Health advanced these principles, including recovery and evidence-based practices [6].
  • Participants in various components of a televised self-help smoking cessation program, based on the American Lung Association's Freedom From Smoking in 20 Days, are compared with a sample of the population of smokers to whom the intervention was addressed [7].
  • Twelve ears with the Nucleus 24 or Freedom implants demonstrated a wide range of d', from 0.7 to 9.6. "Virtual channels" can be implemented through nonsimultaneous stimulation, with comparable pitch discrimination to that observed with simultaneous stimulation [8].
  • This evaluation system is illustrated with a multiyear study of Project Freedom, a substance abuse coalition in a large midwestern city [9].
  • Decline in learning ability best predicts future dementia type: the Freedom House Study [10].

High impact information on Alachlor plus trifluralin

  • One of the two subunits is the product of the CAP2 gene, which we previously identified as the gene encoding the beta subunit of capping protein based on its sequence similarity to capping protein beta subunits in chicken and Dictyostelium (Amatruda, J. F., J. F. Cannon, K. Tatchell, C. Hug, and J. A. Cooper. 1990. Nature (Lond.) 344:352-354) [11].
  • We have previously identified 11 genes whose expression was up- or down-regulated by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse skin keratinocyte progenitor cells (Wei, S.-J., Trempus, C. S., Cannon, R. E., Bortner, C. D., and Tennant, R. W. (2003) J. Biol. Chem. 278, 1758-1768) [12].
  • Recently, Matthias et al., finding indistinguishable de-energization of isolated brown fat mitochondria by fatty acids in UCP1-deficient mice and control mice, challenged this assumption (Matthias, A., Jacobsson, A., Cannon, B., and Nedergaard, J. (1999) J. Biol. Chem. 274, 28150-28160) [13].
  • The naturally occurring Lf receptor deletion mutant FA1090 (LbpB-LbpA-) is infectious, but a Tf receptor mutant of FA1090 is unable to infect male volunteers [Cornelissen, C.N., Kelley, M., Hobbs, M.M., Anderson, J.E., Cannon, J.G., Cohen, M.S., and Sparling, P.F. (1998) Mol Microbiol 27: 611-616] [14].
  • Aortic valve function was assessed by aortic valve area calculations with use of the Gorlin and Cannon formulas [15].

Chemical compound and disease context of Alachlor plus trifluralin


Biological context of Alachlor plus trifluralin


Anatomical context of Alachlor plus trifluralin

  • From a chance encounter with a sea urchin collected near the city of Cannon Beach on the Oregon coast to naturally occurring and functionalized xanthones, it is revealed how these compounds target the Plasmodium parasite's most vulnerable feature--the digestive vacuole [26].
  • Direct interaction of noradrenaline with the cultured brown adipocytes could apparently not mimic the paradoxical destabilization of thermogenin mRNA in vivo, previously observed in the cold-exposed mouse [Jacobsson, Cannon and Nedergaard (1987) FEBS Lett. 244, 353-356], indicating significant differences between the systems in vitro and in vivo [27].
  • These vessels will also provide an advantageous, low maintenance culture system on space station Freedom. Although many types of cells and tissues can potentially utilize this system, our particular interest is in developing bone tissue [28].
  • The intensive research on the hypothalamus by R.W. Hess and associates led to intensified studies on the autoregulated integral functional units of the central nervous system ("dynamic homeostasis," in the words of W.B. Cannon) [29].
  • Islet cell tumors and the alimentary tract: Fourth Walter B. Cannon Lecture [30].

Associations of Alachlor plus trifluralin with other chemical compounds

  • MAIN OUTCOME MEASURES: Freedom from pain at 2 h for frovatriptan versus placebo as Dose 1; use of Dose 2 and/or rescue medication, pain severity, functional impairment and headache recurrence [31].
  • Smoking intervention: combination therapy using nicotine chewing gum and the American Lung Association's "Freedom from Smoking" manuals [32].
  • The materials tested were 22 flowable resin-based restorative materials (Admira Flow, Aelite Flow, Aeliteflow LV, Aria, Crystal Essence, Definite Flow, Dyract Flow, Filtek Flow, FloRestore, Flow-it, Flow-Line, Freedom, Glacier, OmegaFlo, PermaFlo, Photo SC, Revolution 2, Star Flow, Synergy Flow, Tetric Flow, Ultraseal XT and Wave) [33].
  • Fluorescein fundus angiographies performed with the Cannon wide-angle fundus camera enable a good vascular definition, which improves our knowledge of the choroidal circulation [34].
  • The 8th Medical Brigade, deployed to Kuwait in January 2004 in support of Operation Iraqi Freedom provided theater-wide health service support and medical command and control [35].

Gene context of Alachlor plus trifluralin

  • Spontaneous mutations in the gene which encodes the regulatory subunit of cAMP-dependent protein kinase (PKA) of Saccharomyces cerevisiae (BCY1) have been isolated previously [Cannon, J. F., Gibbs, J. B. & Tatchell, K. (1986) Genetics 113, 247-264] by selection of ras2::LEU2 revertants that grew on non-fermentable carbon sources [36].
  • Three of the six mutations (Hopewell, Cannon, Q-5) are predicted to cause the expression of a truncated V2 receptor and are therefore unlikely to function [37].
  • Relative to comparison girls, the girls with ADHD were also significantly more impaired on the Freedom From Distractibility subtests of the WISC-R and on arithmetic and reading achievement scores [38].
  • RESULTS: Freedom from PSA detectability by pathologic stage is 96.3%, 79.4%, and 69.4% for organ confined, specimen confined and margin positive in the absence of seminal vesical invasion with an average 4 years follow up (3-114 months) [39].
  • Stents used included AVE (63%), Freedom (14%), NIR (7%), Palmaz-Schatz (5%), JO (5%), and Multilink (4%) [40].

Analytical, diagnostic and therapeutic context of Alachlor plus trifluralin

  • 1) Freedom from combined cardiac events at 3-year follow-up was greater in patients who had bypass surgery than in those who had coronary angioplasty [41].
  • RESULTS: Freedom from MACE at six years was 76.1% in the stent group, compared with 60.4% in the PTCA group (p = 0.0555) [42].
  • The authors' goal was to determine the influence of anesthesia providers on labor analgesia costs billed to Medicaid. METHODS: Under the Freedom of Information Act, Medicaid provided data on claims paid for 6 months in 2001 for labor analgesia administered during the course of a vaginal delivery [43].
  • Three hundred and nine pregnant women from three public health maternity clinics were assigned randomly to one of three groups with one-third assigned to each: a control group; a group receiving the American Lung Association's Freedom From Smoking Manual; and those receiving A Pregnant Woman's Self-Help Guide to Quit Smoking [44].
  • METHODS: In a total of 113 such consecutive vessels in 107 patients, the flexible Freedom stent was implanted [45].


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  2. Role of flow cytometry to define unacceptable HLA antigens in lung transplant recipients with HLA-specific antibodies. Appel, J.Z., Hartwig, M.G., Cantu, E., Palmer, S.M., Reinsmoen, N.L., Davis, R.D. Transplantation (2006) [Pubmed]
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  4. Paclitaxel-based three-drug combinations for the treatment of small cell lung cancer: a review of the Sarah Cannon Cancer Center experience. Hainsworth, J.D., Burris, H.A., Greco, F.A. Semin. Oncol. (2001) [Pubmed]
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  9. Evaluating community coalitions for prevention of substance abuse: the case of Project Freedom. Fawcett, S.B., Lewis, R.K., Paine-Andrews, A., Francisco, V.T., Richter, K.P., Williams, E.L., Copple, B. Health education & behavior : the official publication of the Society for Public Health Education. (1997) [Pubmed]
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  13. Effects of genetic background on thermoregulation and fatty acid-induced uncoupling of mitochondria in UCP1-deficient mice. Hofmann, W.E., Liu, X., Bearden, C.M., Harper, M.E., Kozak, L.P. J. Biol. Chem. (2001) [Pubmed]
  14. Opposing selective forces for expression of the gonococcal lactoferrin receptor. Anderson, J.E., Hobbs, M.M., Biswas, G.D., Sparling, P.F. Mol. Microbiol. (2003) [Pubmed]
  15. Orifice variability of the stenotic aortic valve: evaluation before and after balloon aortic valvuloplasty. Paulus, W.J., Sys, S.U., Heyndrickx, G.R., Andries, E. J. Am. Coll. Cardiol. (1991) [Pubmed]
  16. Bronchoscopy in the blast injury patient. Eckert, M.J., Clagett, C., Martin, M., Azarow, K. Archives of surgery (Chicago, Ill. : 1960) (2006) [Pubmed]
  17. Probucol-associated tachyarrhythmic events and QT prolongation: importance of gender. Reinoehl, J., Frankovich, D., Machado, C., Kawasaki, R., Baga, J.J., Pires, L.A., Steinman, R.T., Fromm, B.S., Lehmann, M.H. Am. Heart J. (1996) [Pubmed]
  18. The President's New Freedom Commission: Capitalizing on Opportunities to Advance School-Based Mental Health Services. Mills, C., Stephan, S.H., Moore, E., Weist, M.D., Daly, B.P., Edwards, M. Clinical child and family psychology review (2006) [Pubmed]
  19. Clinical case series: the use of Prazosin for combat-related recurrent nightmares among Operation Iraqi Freedom combat veterans. Daly, C.M., Doyle, M.E., Radkind, M., Raskind, E., Daniels, C. Military medicine. (2005) [Pubmed]
  20. Glucose-6-phosphate dehydrogenase deficiency in two returning Operation Iraqi Freedom soldiers who developed hemolytic anemia while receiving primaquine prophylaxis for malaria. Carr, M.E., Fandre, M.N., Oduwa, F.O. Military medicine. (2005) [Pubmed]
  21. An application of the revised CONSORT standards to FDA summary reports of recently approved antidepressants and antipsychotics. Khan, A., Khan, S.R., Leventhal, R.M., Krishnan, K.R., Gorman, J.M. Biol. Psychiatry (2002) [Pubmed]
  22. The tobacco industry and pesticide regulations: case studies from tobacco industry archives. McDaniel, P.A., Solomon, G., Malone, R.E. Environ. Health Perspect. (2005) [Pubmed]
  23. A standard definition of disease freedom is needed for prostate cancer: undetectable prostate specific antigen compared with the American Society of Therapeutic Radiology and Oncology consensus definition. Critz, F.A. J. Urol. (2002) [Pubmed]
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