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MeSH Review

Total Lung Capacity

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Disease relevance of Total Lung Capacity


High impact information on Total Lung Capacity

  • Lung function deteriorated in all nine patients in the group given prednisolone alone: total lung capacity decreased from a mean (+/-SD) of 66+/-8 percent of the predicted value at base line to 62+/-6 percent at 12 months [6].
  • The single breath carbon monoxide diffusing capacity was below 80 per cent of the predicted value in 24 patients (80 per cent), and a reduced total lung capacity was present in 13 (43 per cent) [7].
  • We have anecdotally observed that the 5 breath to total lung capacity (TLC) dosimeter method reduced the response to methacholine in some subjects with mild AHR [8].
  • In patients not receiving steroid treatment there was a positive correlation between exhaled ethane and NO (r = 0.55, p < 0.05) and air trapping assessed by the ratio of residual volume to total lung capacity (RV/ TLC) (r = 0.60, p < 0.05) [9].
  • The fenoterol was given in the nose by means of two puffs of 0.2 mg in each nostril (total of 0.8 mg) from a pressurized canister while the patient was holding his breath at total lung capacity; it was followed by an exhalation through the nose [10].

Chemical compound and disease context of Total Lung Capacity


Biological context of Total Lung Capacity


Associations of Total Lung Capacity with chemical compounds


Gene context of Total Lung Capacity

  • METHODS: Voluntary relaxed expiration from total lung capacity (TLC) was studied in three groups of subjects: seven patients with severe chronic airways obstruction (COPD), 10 normal subjects, and 15 subjects with restrictive disease [23].
  • Infection and rejection were accompanied by airflow obstruction, a rise in the slopes of the alveolar plateaus for nitrogen, hexafluoride sulphur and helium (SN2, SSF6, and SHe), and a decrease in the difference between SSF6 and SHe (delta S), total lung capacity (TLC), and lung transfer factor (TLCO) [24].
  • Pulmonary function tests in ten of the 13 patients revealed (mean percent predicted +/- 1 SD): vital capacity 92 +/- 12, residual volume 85 +/- 31, total lung capacity 92 +/- 13, peak flow rate 96 +/- 17, forced expiratory volume in 1 second 90 +/- 13, and maximal mid-expiratory flow rate 93 +/- 25 [25].
  • Reproducibility of RVN2 was assessed from duplicate measurements in 73 patients with asthma before and after bronchodilation (FEV1 81.4 +/- 13.7 and 99.6 +/- 11.5% pred, respectively), and in nine patients with CF; the total lung capacity (TLC) was unaffected by bronchodilation; 3,797 +/- 830 ml and 3,807 +/- 843 ml, respectively [26].
  • Changes in residual volume relative to vital capacity and total lung capacity after arthrodesis of the spine in patients who have adolescent idiopathic scoliosis [27].

Analytical, diagnostic and therapeutic context of Total Lung Capacity


  1. Double intratracheal instillation of keratinocyte growth factor prevents bleomycin-induced lung fibrosis in rats. Sugahara, K., Iyama, K., Kuroda, M.J., Sano, K. J. Pathol. (1998) [Pubmed]
  2. Critical evaluation of computerised x ray planimetry for the measurement of lung volumes. Spence, D.P., Kelly, Y.J., Ahmed, J., Calverley, P.M., Pearson, M.G. Thorax (1995) [Pubmed]
  3. Interpretation of lung function tests in the sickle-cell haemoglobinopathies. Miller, G.J., Serjeant, G.R., Saunders, M.J., Richardson, C., Gilson, R.J. Thorax (1978) [Pubmed]
  4. The effect of transfusion on lung capacity, diffusing capacity, and arterial oxygen saturation in patients with thalassemia major. Grant, G.P., Mansell, A.L., Graziano, J.H., Mellins, R.B. Pediatr. Res. (1986) [Pubmed]
  5. The influence of lung volume on gas transfer in scoliosis. Siegler, D., Zorab, P.A. British journal of diseases of the chest. (1982) [Pubmed]
  6. A preliminary study of long-term treatment with interferon gamma-1b and low-dose prednisolone in patients with idiopathic pulmonary fibrosis. Ziesche, R., Hofbauer, E., Wittmann, K., Petkov, V., Block, L.H. N. Engl. J. Med. (1999) [Pubmed]
  7. Diaphragm function and lung involvement in systemic lupus erythematosus. Gibson, C.J., Edmonds, J.P., Hughes, G.R. Am. J. Med. (1977) [Pubmed]
  8. Dosimeter methacholine challenge: comparison of maximal versus submaximal inhalations. Todd, D.C., Davis, B.E., Hurst, T.S., Cockcroft, D.W. J. Allergy Clin. Immunol. (2004) [Pubmed]
  9. Elevation of exhaled ethane concentration in asthma. Paredi, P., Kharitonov, S.A., Barnes, P.J. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  10. Intranasal fenoterol in asthmatic subjects: an alternative route of administration. Groth, S., Dirksen, H., Mygind, N. J. Allergy Clin. Immunol. (1984) [Pubmed]
  11. Mechanisms for isolated volume response to a bronchodilator in patients with COPD. Cerveri, I., Pellegrino, R., Dore, R., Corsico, A., Fulgoni, P., van de Woestijne, K.P., Brusasco, V. J. Appl. Physiol. (2000) [Pubmed]
  12. Lung statics and connective tissues after penicillamine in bleomycin-treated hamsters. Fedullo, A.J., Karlinsky, J.B., Snider, G.L., Goldstein, R.H. Journal of applied physiology: respiratory, environmental and exercise physiology. (1980) [Pubmed]
  13. The immediate effects of cortisol on pulmonary function in normals and asthmatics. Ramsdell, J.W., Berry, C.C., Clausen, J.L. J. Allergy Clin. Immunol. (1983) [Pubmed]
  14. Standardization of inhalation provocation tests: influence of nebulizer output, particle size, and method of inhalation. Ryan, G., Dolovich, M.B., Obminski, G., Cockcroft, D.W., Juniper, E., Hargreave, F.E., Newhouse, M.T. J. Allergy Clin. Immunol. (1981) [Pubmed]
  15. Effects of mitral valve surgery on static lung function and exercise performance. Rhodes, K.M., Evemy, K., Nariman, S., Gibson, G.J. Thorax (1985) [Pubmed]
  16. Acute changes of lung volumes and lung mechanics in asthma and in normal subjects. Holmes, P.W., Campbell, A.H., Barter, C.E. Thorax (1978) [Pubmed]
  17. The effects of early pneumonectomy on the remaining pulmonary parenchyma. Wilcox, B.R., Murray, G.F., Friedman, M., Pimmel, R.L. Surgery (1979) [Pubmed]
  18. Physiologic effects of inhaled histamine in asthma: reversible changes in pulmonary mechanics and total lung capacity. Bleecker, E.R., Rosenthal, R.R., Menkes, H.A., Norman, P.S., Permutt, S. J. Allergy Clin. Immunol. (1979) [Pubmed]
  19. Effects of cardioselective and nonselective beta-adrenergic antagonists on pulmonary mechanics. Foley, J.E., Sigurdson, M.J., Conliffe, T.F., Fand, R.S., Anthonisen, N.R. Clin. Pharmacol. Ther. (1982) [Pubmed]
  20. Post-mortem lung volumes. Thurlbeck, W.M. Thorax (1979) [Pubmed]
  21. Effect of measurement conditions on measured levels of peak exhaled nitric oxide. Byrnes, C.A., Dinarevic, S., Busst, C.A., Shinebourne, E.A., Bush, A. Thorax (1997) [Pubmed]
  22. Keratinocyte growth factor reduces lung damage due to acid instillation in rats. Yano, T., Deterding, R.R., Simonet, W.S., Shannon, J.M., Mason, R.J. Am. J. Respir. Cell Mol. Biol. (1996) [Pubmed]
  23. Difference between functional residual capacity and elastic equilibrium volume in patients with chronic obstructive pulmonary disease. Morris, M.J., Madgwick, R.G., Lane, D.J. Thorax (1996) [Pubmed]
  24. Role of pulmonary function in the detection of allograft dysfunction after heart-lung transplantation. Van Muylem, A., Mélot, C., Antoine, M., Knoop, C., Estenne, M. Thorax (1997) [Pubmed]
  25. Empyema in children: clinical course and long-term follow-up. McLaughlin, F.J., Goldmann, D.A., Rosenbaum, D.M., Harris, G.B., Schuster, S.R., Strieder, D.J. Pediatrics (1984) [Pubmed]
  26. Lung volumes measured by the forced rebreathing technique in children with airways obstruction. Merkus, P.J., Verver, S., van Essen-Zandvliet, E.E., Duiverman, E.J., Kerrebijn, K.F., Quanjer, P.H. Eur. Respir. J. (1992) [Pubmed]
  27. Changes in residual volume relative to vital capacity and total lung capacity after arthrodesis of the spine in patients who have adolescent idiopathic scoliosis. Smith, R.M., Dickson, R.A. The Journal of bone and joint surgery. American volume. (1994) [Pubmed]
  28. Reduction of pulmonary capillary blood volume in patients with severe unexplained pulmonary hypertension. Borland, C., Cox, Y., Higenbottam, T. Thorax (1996) [Pubmed]
  29. Cyclophosphamide in the treatment of idiopathic pulmonary fibrosis: a prospective study in patients who failed to respond to corticosteroids. Zisman, D.A., Lynch, J.P., Toews, G.B., Kazerooni, E.A., Flint, A., Martinez, F.J. Chest (2000) [Pubmed]
  30. Effect of a microaerosol barrier filter on the measurement of lung function. Johns, D.P., Ingram, C., Booth, H., Williams, T.J., Walters, E.H. Chest (1995) [Pubmed]
  31. Oxygen radicals in the nonvagal component of noncholinergic airway constriction. Zhang, H.Q., Tai, H.H., Lai, Y.L. Respiration physiology. (1996) [Pubmed]
  32. Diaphragm thickness heterogeneity at functional residual capacity and total lung capacity. Wait, J.L., Staworn, D., Poole, D.C. J. Appl. Physiol. (1995) [Pubmed]
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