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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MAFF  -  v-maf avian musculoaponeurotic...

Homo sapiens

Synonyms: Transcription factor MafF, U-MAF, U-Maf, V-maf musculoaponeurotic fibrosarcoma oncogene homolog F, hMafF
 
 
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Disease relevance of MAFF

  • Moreover, Rps. palustris strains were differentiated from the nodule-forming B. japonicum, Mezorhizobium loti MAFF 303099 and Sinorhizobium sp. NGR 234 in the FPP synthase phylogeny [1].
 

High impact information on MAFF

  • Time course experiments revealed a rapid induction of MAFF transcripts within 30 min following IL1B treatment [2].
  • Our results suggest a possible specific role for MAFF in proinflammatory cytokine-mediated control of myometrial gene expression and provide the first link between a small MAF transcription factor and the inflammatory response [2].
  • The presence of actinomycin D inhibited the upregulation, suggesting that regulation of MAFF mRNA levels occurs at the transcriptional level [2].
  • The human transcription factor MafF (hMafF) lacks a transactivation domain, it contains a heptad-leucine repeat motif (viz., Leu-zipper) that may mediate protein-protein interactions to regulate transcriptional activities [3].
  • Commentary on the MAFF technical report: a review of antimicrobial resistance in the food chain. Ministry of Agriculture Fisheries and Food [4].
 

Biological context of MAFF

  • Recognising the potential value of applying these techniques in the food industry, the Ministry of Agriculture, Fisheries and Food (MAFF) initiated a nationally coordinated five-year programme of research into the growth and survival of microorganisms in foods, with the aim of developing a computerised Predictive Microbiology Database in the UK [5].
 

Anatomical context of MAFF

  • Here we analyzed the regulation of the human MAFF gene, coding for a small MAF transcription factor, in uterine smooth muscle cells [2].
 

Associations of MAFF with chemical compounds

  • Concentrations of nitrate and nitrite have been determined in a range of foods and the dietary intake estimated from the MAFF Total Diet Study. The estimated dietary intake of nitrate ion for the UK population was 54 mg/day and the estimated dietary intake of nitrite ion was in the range 2.4-4.2 mg/day in 1985 [6].
  • A review of the MAFF Optimal Nutrition Status research programme: folate, iron and copper [7].
 

Other interactions of MAFF

  • Appointment of medical officers of health (food safety) is essential for achieving food safety objectives in the UK. Response to food borne illness section (4.44-4.49) of the White Paper, the Food Standard Agency--a force for change, MAFF January 1998 [8].

References

  1. Evolutionary relationship of phototrophic bacteria in the alpha-Proteobacteria based on farnesyl diphosphate synthase. Cantera, J.J., Kawasaki, H., Seki, T. Microbiology (Reading, Engl.) (2002) [Pubmed]
  2. Regulation of the MAFF transcription factor by proinflammatory cytokines in myometrial cells. Massrieh, W., Derjuga, A., Doualla-Bell, F., Ku, C.Y., Sanborn, B.M., Blank, V. Biol. Reprod. (2006) [Pubmed]
  3. The novel human gene MIP functions as a co-activator of hMafF. Ye, X., Li, Y., Huang, Q., Yu, Y., Yuan, H., Wang, P., Wan, D., Gu, J., Huo, K., Li, Y.Y., Lu, H. Arch. Biochem. Biophys. (2006) [Pubmed]
  4. Commentary on the MAFF technical report: a review of antimicrobial resistance in the food chain. Ministry of Agriculture Fisheries and Food. Donnelly, J.P. Int. J. Antimicrob. Agents (1999) [Pubmed]
  5. Modelling the growth, survival and death of microorganisms in foods: the UK food micromodel approach. McClure, P.J., Blackburn, C.W., Cole, M.B., Curtis, P.S., Jones, J.E., Legan, J.D., Ogden, I.D., Peck, M.W., Roberts, T.A., Sutherland, J.P. Int. J. Food Microbiol. (1994) [Pubmed]
  6. Nitrate and nitrite in foods and the diet. Meah, M.N., Harrison, N., Davies, A. Food additives and contaminants. (1994) [Pubmed]
  7. A review of the MAFF Optimal Nutrition Status research programme: folate, iron and copper. Buttriss, J., Hughes, J. Public health nutrition. (2002) [Pubmed]
  8. Appointment of medical officers of health (food safety) is essential for achieving food safety objectives in the UK. Response to food borne illness section (4.44-4.49) of the White Paper, the Food Standard Agency--a force for change, MAFF January 1998. Bakhshi, S.S. Public health. (1998) [Pubmed]
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