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Capn10  -  calpain 10

Mus musculus

Synonyms: AW049679, CANP 10, Calcium-activated neutral proteinase 10, Calpain-10, Capn8, ...
 
 
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High impact information on Capn10

  • Studies of the genetic basis of type 2 diabetes suggest that variation in the calpain-10 gene affects susceptibility to this common disorder, raising the possibility that calpain-sensitive pathways may play a role in regulating insulin secretion and/or action [1].
  • Because of recent studies showing linkage of type 2 diabetes with the calpain 10 gene, we investigated the ability of calpains to regulate GLUT4 expression in 3T3-L1 adipocytes [2].
  • In contrast, calpain 2, Lp85, and calpain 10 may have roles in cell signaling pathways [3].
  • Robust peri-nuclear localization of calpain 10 was observed in the head ectoderm, lens placode, and optic vesicle during early eye induction [3].
  • Further, calpain 10 protein was maintained in the lens epithelium of pre- and post-natal lens [3].
 

Biological context of Capn10

 

Analytical, diagnostic and therapeutic context of Capn10

References

  1. Calpains play a role in insulin secretion and action. Sreenan, S.K., Zhou, Y.P., Otani, K., Hansen, P.A., Currie, K.P., Pan, C.Y., Lee, J.P., Ostrega, D.M., Pugh, W., Horikawa, Y., Cox, N.J., Hanis, C.L., Burant, C.F., Fox, A.P., Bell, G.I., Polonsky, K.S. Diabetes (2001) [Pubmed]
  2. GLUT4 expression in 3T3-L1 adipocytes is repressed by proteasome inhibition, but not by inhibition of calpains. Cooke, D.W., Patel, Y.M. Mol. Cell. Endocrinol. (2005) [Pubmed]
  3. Protein expression patterns for ubiquitous and tissue specific calpains in the developing mouse lens. Reed, N.A., Castellini, M.A., Ma, H., Shearer, T.R., Duncan, M.K. Exp. Eye Res. (2003) [Pubmed]
  4. A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin. Zhou, Y.P., Sreenan, S., Pan, C.Y., Currie, K.P., Bindokas, V.P., Horikawa, Y., Lee, J.P., Ostrega, D., Ahmed, N., Baldwin, A.C., Cox, N.J., Fox, A.P., Miller, R.J., Bell, G.I., Polonsky, K.S. Metab. Clin. Exp. (2003) [Pubmed]
 
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