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Gene Review

Capn2  -  calpain 2

Mus musculus

Synonyms: 80 kDa M-calpain subunit, AI326419, CALP80, CANP 2, Calcium-activated neutral proteinase 2, ...
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Disease relevance of Capn2


High impact information on Capn2


Biological context of Capn2


Anatomical context of Capn2


Other interactions of Capn2


Analytical, diagnostic and therapeutic context of Capn2


  1. Third form of calcium-activated neutral proteinase from calf brain: purification, partial characterization and comparison of properties with other forms. Malik, M.N., Fenko, M.D., Sheikh, A.M., Kascsak, R.J., Tonna-DeMasi, M.S., Wisniewski, H.M. Biochim. Biophys. Acta (1987) [Pubmed]
  2. Cyclin E both regulates and is regulated by calpain 2, a protease associated with metastatic breast cancer phenotype. Libertini, S.J., Robinson, B.S., Dhillon, N.K., Glick, D., George, M., Dandekar, S., Gregg, J.P., Sawai, E., Mudryj, M. Cancer Res. (2005) [Pubmed]
  3. Calpain-2 as a target for limiting prostate cancer invasion. Mamoune, A., Luo, J.H., Lauffenburger, D.A., Wells, A. Cancer Res. (2003) [Pubmed]
  4. Spatial localization of m-calpain to the plasma membrane by phosphoinositide biphosphate binding during epidermal growth factor receptor-mediated activation. Shao, H., Chou, J., Baty, C.J., Burke, N.A., Watkins, S.C., Stolz, D.B., Wells, A. Mol. Cell. Biol. (2006) [Pubmed]
  5. Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division. Arthur, J.S., Elce, J.S., Hegadorn, C., Williams, K., Greer, P.A. Mol. Cell. Biol. (2000) [Pubmed]
  6. Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells. Gomperts, B.N., Gong-Cooper, X., Hackett, B.P. J. Cell. Sci. (2004) [Pubmed]
  7. Mechanical unloading of the heart activates the calpain system. Razeghi, P., Volpini, K.C., Wang, M.E., Youker, K.A., Stepkowski, S., Taegtmeyer, H. J. Mol. Cell. Cardiol. (2007) [Pubmed]
  8. Protein expression patterns for ubiquitous and tissue specific calpains in the developing mouse lens. Reed, N.A., Castellini, M.A., Ma, H., Shearer, T.R., Duncan, M.K. Exp. Eye Res. (2003) [Pubmed]
  9. Differential influence of proteolysis by calpain 2 and Lp82 on in vitro precipitation of mouse lens crystallins. Azuma, M., Tamada, Y., Kanaami, S., Nakajima, E., Nakamura, Y., Fukiage, C., Forsberg, N.E., Duncan, M.K., Shearer, T.R. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  10. Isoform specific function of calpain 2 in regulating membrane protrusion. Franco, S., Perrin, B., Huttenlocher, A. Exp. Cell Res. (2004) [Pubmed]
  11. The expression of calpain 1 and calpain 2 in spermatogenic cells and spermatozoa of the mouse. Ben-Aharon, I., Brown, P.R., Etkovitz, N., Eddy, E.M., Shalgi, R. Reproduction (2005) [Pubmed]
  12. Lack of phenotype for LTP and fear conditioning learning in calpain 1 knock-out mice. Grammer, M., Kuchay, S., Chishti, A., Baudry, M. Neurobiology of learning and memory. (2005) [Pubmed]
  13. M-calpain levels increase during fusion of myoblasts in the mutant muscular dysgenesis (mdg) mouse. Joffroy, S., Dourdin, N., Delage, J.P., Cottin, P., Koenig, J., Brustis, J.J. Int. J. Dev. Biol. (2000) [Pubmed]
  14. Gene expression analysis suggests that 1,25-dihydroxyvitamin D3 reverses experimental autoimmune encephalomyelitis by stimulating inflammatory cell apoptosis. Spach, K.M., Pedersen, L.B., Nashold, F.E., Kayo, T., Yandell, B.S., Prolla, T.A., Hayes, C.E. Physiol. Genomics (2004) [Pubmed]
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