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Gene Review

Papss1  -  3'-phosphoadenosine 5'-phosphosulfate...

Mus musculus

Synonyms: AI325286, Asapk, Atpsk1, Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1, PAPS synthase 1, ...
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High impact information on Papss1

  • We conclude that a family of SK genes are responsible for sulfate activation in mammals, that a mutation in SK2 causes murine brachymorphism, and that members of this gene family have nonredundant, tissue-specific roles [1].
  • In higher organisms PAPS synthesis is catalyzed by a bifunctional sulfurylase kinase (SK) polypeptide having both ATP-sulfurylase and adenosine-phosphosulfate kinase activities [1].
  • PAPS synthetase (SK) catalyzes the two sequential reactions of phosphoadenosine phosphosulfate (PAPS) synthesis [2].
  • This led to the isolation of cDNA clones for a novel human adenosine 5'-phosphosulphate kinase/ATP sulphurylase (PAPS synthetase) [3].
  • 2. This locus has synteny with the mouse brachymorphic gene recently identified as a PAPS synthetase (SK2) [3].

Biological context of Papss1

  • The free regulatory and catalytic subunits from both S and R kinase are thermolabile, when associated in the holoenzyme the two subunits are more stable to heat inactivation in R kinase than in S kinase [4].

Anatomical context of Papss1

  • To test for a role for SK(Ca) channels, we overexpressed K(Ca)2.1 (SK1) and K(Ca)2.2 (SK2), the predominant SK(Ca) subunits expressed in the cortex, in pyramidal cells of cultured brain slices [5].

Associations of Papss1 with chemical compounds

  • The regulatory subunit of S kinase can be stabilized against heat inactivation by cyclic AMP binding both at 2-10(-7) and 10(-5) M cyclic AMP concentrations [4].


  1. A member of a family of sulfate-activating enzymes causes murine brachymorphism. Kurima, K., Warman, M.L., Krishnan, S., Domowicz, M., Krueger, R.C., Deyrup, A., Schwartz, N.B. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Identification and functional characterization of the novel BM-motif in the murine phosphoadenosine phosphosulfate (PAPS) synthetase. Singh, B., Schwartz, N.B. J. Biol. Chem. (2003) [Pubmed]
  3. Molecular cloning of a novel human PAPS synthetase which is differentially expressed in metastatic and non-metastatic colon carcinoma cells. Franzon, V.L., Gibson, M.A., Hatzinikolas, G., Woollatt, E., Sutherland, G.R., Cleary, E.G. Int. J. Biochem. Cell Biol. (1999) [Pubmed]
  4. Altered regulation of cyclic AMP-dependent protein kinase in a mouse lymphoma cell line. Lasser, M., Daniel, V. Biochim. Biophys. Acta (1977) [Pubmed]
  5. SKCa channels mediate the medium but not the slow calcium-activated afterhyperpolarization in cortical neurons. Villalobos, C., Shakkottai, V.G., Chandy, K.G., Michelhaugh, S.K., Andrade, R. J. Neurosci. (2004) [Pubmed]
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