The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PAPSS1  -  3'-phosphoadenosine 5'-phosphosulfate...

Homo sapiens

Synonyms: ATPSK1, Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1, PAPS synthase 1, PAPSS, PAPSS 1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PAPSS1


High impact information on PAPSS1


Biological context of PAPSS1


Anatomical context of PAPSS1

  • After optimal PAPSS assay conditions had been established, substrate kinetic studies were performed with cytosol preparations from human liver and cerebral cortex, two tissues with very different expression patterns for PAPSS1 and PAPSS2 mRNA [6].
  • PAPSS1 located in the chromosome 4q23 deficiency and consequent effect in lymphocyte recruitment in High Endothelial Venules has been reported [7].
  • In brain and skin PAPSS1 is the major expressed isoform, whereas in liver, cartilage and adrenal glands PAPSS2 isoform expression predominates and in various other tissues the proportions of the isoform expressions is purported to vary [7].
  • The cDNA for human PAPS synthase (hPAPSS) along with polymerase chain reaction products corresponding to several NH2- and COOH-terminal fragments were cloned and expressed in COS-1 cells [1].
  • As a result of SK1 overexpression, migration and Ca(2+)-response of human pulmonary artery endothelial cells (HPAEC) to stimulation with external S1P, but not thrombin, was strongly impaired [8].

Associations of PAPSS1 with chemical compounds


Other interactions of PAPSS1

  • This coupled assay uses the sulfation of 17beta-[(3)H]estradiol catalyzed by recombinant human SULT1E1 to measure PAPS, which has been generated by PAPSS during the initial step of the assay [6].

Analytical, diagnostic and therapeutic context of PAPSS1


  1. Molecular cloning, expression, and characterization of human bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase and its functional domains. Venkatachalam, K.V., Akita, H., Strott, C.A. J. Biol. Chem. (1998) [Pubmed]
  2. Nuclear localization of PAPS synthetase 1: a sulfate activation pathway in the nucleus of eukaryotic cells. Besset, S., Vincourt, J.B., Amalric, F., Girard, J.P. FASEB J. (2000) [Pubmed]
  3. Sulfation in high endothelial venules: cloning and expression of the human PAPS synthetase. Girard, J.P., Baekkevold, E.S., Amalric, F. FASEB J. (1998) [Pubmed]
  4. Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization. Xu, Z.H., Otterness, D.M., Freimuth, R.R., Carlini, E.J., Wood, T.C., Mitchell, S., Moon, E., Kim, U.J., Xu, J.P., Siciliano, M.J., Weinshilboum, R.M. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  5. Pharmacogenetics of human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1): gene resequencing, sequence variation, and functional genomics. Xu, Z.H., Thomae, B.A., Eckloff, B.W., Wieben, E.D., Weinshilboum, R.M. Biochem. Pharmacol. (2003) [Pubmed]
  6. Human 3'-phosphoadenosine 5'-phosphosulfate synthetase: radiochemical enzymatic assay, biochemical properties, and hepatic variation. Xu, Z., Wood, T.C., Adjei, A.A., Weinshilboum, R.M. Drug Metab. Dispos. (2001) [Pubmed]
  7. Human 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase: biochemistry, molecular biology and genetic deficiency. Venkatachalam, K.V. IUBMB Life (2003) [Pubmed]
  8. De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells. Berdyshev, E.V., Gorshkova, I.A., Usatyuk, P., Zhao, Y., Saatian, B., Hubbard, W., Natarajan, V. Cell. Signal. (2006) [Pubmed]
  9. Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPSS2) pharmacogenetics: gene resequencing, genetic polymorphisms and functional characterization of variant allozymes. Xu, Z.H., Freimuth, R.R., Eckloff, B., Wieben, E., Weinshilboum, R.M. Pharmacogenetics (2002) [Pubmed]
  10. Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domains. Lansdon, E.B., Fisher, A.J., Segel, I.H. Biochemistry (2004) [Pubmed]
  11. Domain analysis of the calcium-activated potassium channel SK1 from rat brain. Functional expression and toxin sensitivity. D'hoedt, D., Hirzel, K., Pedarzani, P., Stocker, M. J. Biol. Chem. (2004) [Pubmed]
WikiGenes - Universities