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Gene Review

Papss  -  PAPS synthetase

Drosophila melanogaster

Synonyms: CG8363, DmPAPSS, Dmel\CG8363, PAPS, PAPSS, ...
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Disease relevance of Paps


High impact information on Paps


Anatomical context of Paps


Associations of Paps with chemical compounds

  • PAPS synthetase is a bifunctional enzyme containing both ATP sulfurylase and APS kinase activities required for the biosynthesis of PAPS, the sulfate donor in sulfation reactions [4].
  • Surprisingly, however, our results also indicated that formation of the embryonic DV axis does not require the synthesis of the high-energy sulfate donor, 3'-phosphoadenosine 5'-phosphosulfate (PAPS) in the follicle cells in which Pipe is presumed to function [2].


  1. Molecular Cloning and Characterization of a Novel 3'-Phosphoadenosine 5'-Phosphosulfate Transporter, PAPST2. Kamiyama, S., Sasaki, N., Goda, E., Ui-Tei, K., Saigo, K., Narimatsu, H., Jigami, Y., Kannagi, R., Irimura, T., Nishihara, S. J. Biol. Chem. (2006) [Pubmed]
  2. Synthesis of the sulfate donor PAPS in either the Drosophila germline or somatic follicle cells can support embryonic dorsal-ventral axis formation. Zhu, X., Stevens, L.M., Stein, D. Development (2007) [Pubmed]
  3. Identification and characterization of a novel Drosophila 3'-phosphoadenosine 5'-phosphosulfate transporter. Goda, E., Kamiyama, S., Uno, T., Yoshida, H., Ueyama, M., Kinoshita-Toyoda, A., Toyoda, H., Ueda, R., Nishihara, S. J. Biol. Chem. (2006) [Pubmed]
  4. cDNA sequence and expression pattern of the Drosophila melanogaster PAPS synthetase gene: a new salivary gland marker. Jullien, D., Crozatier, M., Käs, E. Mech. Dev. (1997) [Pubmed]
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