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Gene Review:

Malt1 - mucosa associated lymphoid tissue lymphoma...

Mus musculus

Synonyms: A630046N12, D430033E09Rik, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog, Paracaspase, paracaspase

Ruland, J. et al., Ruefli-Brasse, A.A. et al., Klemm, S. et al., Klemm, S. et al., Gross, O. et al., et al.

Ruland, Duncan, Wakeham, Mak,

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Disease relevance of Malt1

We identify B cell lymphoma 10 (Bcl10) and mucosa-associated lymphoid tissue 1 (Malt1) as novel key regulators of mast cell signaling [1].

High impact information on Malt1

In contrast to Bcl10 disruption, however, inactivation of Malt1 has only mild effects on B cell activation and does not cause defects during neurodevelopment [2].
Differential requirement for Malt1 in T and B cell antigen receptor signaling [2].
Bcl10 and Malt1 control lysophosphatidic acid-induced NF-{kappa}B activation and cytokine production [3].
Yet, Card9 is dispensable for antigen receptor signalling that uses Carma1 as a link to Bcl10-Malt1 [4].
We demonstrate that primary T and B lymphocytes from paracaspase-deficient mice are defective in antigen-receptor-induced NF-kappaB activation, cytokine production, and proliferation [5].

Biological context of Malt1

Immunology. The paracaspase connection [6].

Anatomical context of Malt1

Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase [5].

Physical interactions of Malt1

Although the paracaspase MALT1 can bind to BCL10, the physiological function of MALT1 is unknown [2].

References

The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation. Klemm, S., Gutermuth, J., Hültner, L., Sparwasser, T., Behrendt, H., Peschel, C., Mak, T.W., Jakob, T., Ruland, J. J. Exp. Med. (2006) [Pubmed]
Differential requirement for Malt1 in T and B cell antigen receptor signaling. Ruland, J., Duncan, G.S., Wakeham, A., Mak, T.W. Immunity (2003) [Pubmed]
Bcl10 and Malt1 control lysophosphatidic acid-induced NF-{kappa}B activation and cytokine production. Klemm, S., Zimmermann, S., Peschel, C., Mak, T.W., Ruland, J. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Gross, O., Gewies, A., Finger, K., Schäfer, M., Sparwasser, T., Peschel, C., Förster, I., Ruland, J. Nature (2006) [Pubmed]
Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase. Ruefli-Brasse, A.A., French, D.M., Dixit, V.M. Science (2003) [Pubmed]
Immunology. The paracaspase connection. Yu, L., Lenardo, M.J. Science (2003) [Pubmed]

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