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Gene Review

Malt1  -  mucosa associated lymphoid tissue lymphoma...

Mus musculus

Synonyms: A630046N12, D430033E09Rik, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog, Paracaspase, paracaspase
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Disease relevance of Malt1


High impact information on Malt1


Biological context of Malt1


Anatomical context of Malt1


Physical interactions of Malt1

  • Although the paracaspase MALT1 can bind to BCL10, the physiological function of MALT1 is unknown [2].


  1. The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation. Klemm, S., Gutermuth, J., Hültner, L., Sparwasser, T., Behrendt, H., Peschel, C., Mak, T.W., Jakob, T., Ruland, J. J. Exp. Med. (2006) [Pubmed]
  2. Differential requirement for Malt1 in T and B cell antigen receptor signaling. Ruland, J., Duncan, G.S., Wakeham, A., Mak, T.W. Immunity (2003) [Pubmed]
  3. Bcl10 and Malt1 control lysophosphatidic acid-induced NF-{kappa}B activation and cytokine production. Klemm, S., Zimmermann, S., Peschel, C., Mak, T.W., Ruland, J. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  4. Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Gross, O., Gewies, A., Finger, K., Schäfer, M., Sparwasser, T., Peschel, C., Förster, I., Ruland, J. Nature (2006) [Pubmed]
  5. Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase. Ruefli-Brasse, A.A., French, D.M., Dixit, V.M. Science (2003) [Pubmed]
  6. Immunology. The paracaspase connection. Yu, L., Lenardo, M.J. Science (2003) [Pubmed]
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