The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Card11  -  caspase recruitment domain family, member 11

Mus musculus

Synonyms: 0610008L17Rik, 2410011D02Rik, BIMP3, CARMA1, Caspase recruitment domain-containing protein 11
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Card11

  • Compared with wild-type controls, CARMA1(-/-) mice did not develop airway eosinophilia, had no significant T cell recruitment into the airways, and had no evidence for T cell activation in the lung or draining lymph nodes [1].
  • In addition, the CARMA1(-/-) mice had significantly decreased levels of IL-4, IL-5, and IL-13, did not produce IgE, and did not develop airway hyperresponsiveness or mucus cell hypertrophy [1].

High impact information on Card11

  • The mutant TCR poorly recruits the protein adaptor Carma-1 and is subsequently impaired in activating NF-kappaB [2].
  • The mutation alters a conserved leucine in the coiled-coil domain of CARMA-1/CARD11, a member of the MAGUK protein family implicated in organizing multimolecular signaling complexes [3].
  • Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis [3].
  • We report that genetic inactivation of the MAGUK family protein CARD11/Carma1/Bimp3 results in a complete block in T and B cell immunity [4].
  • The activation of lymphocytes is in their CARMA [5].

Biological context of Card11


Anatomical context of Card11


Associations of Card11 with chemical compounds


Regulatory relationships of Card11


Other interactions of Card11

  • Yet, Card9 is dispensable for antigen receptor signalling that uses Carma1 as a link to Bcl10-Malt1 [11].
  • Carma1 (also known as caspase recruitment domain [CARD]11, Bimp3) is a CARD-containing membrane-associated guanylate kinase family protein that plays an essential role in antigen receptor-induced nuclear factor kappaB activation [10].
  • Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1 [12].


  1. CARMA1 is critical for the development of allergic airway inflammation in a murine model of asthma. Medoff, B.D., Seed, B., Jackobek, R., Zora, J., Yang, Y., Luster, A.D., Xavier, R. J. Immunol. (2006) [Pubmed]
  2. T cell division and death are segregated by mutation of TCRbeta chain constant domains. Teixeiro, E., Daniels, M.A., Hausmann, B., Schrum, A.G., Naeher, D., Luescher, I., Thome, M., Bragado, R., Palmer, E. Immunity (2004) [Pubmed]
  3. Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Jun, J.E., Wilson, L.E., Vinuesa, C.G., Lesage, S., Blery, M., Miosge, L.A., Cook, M.C., Kucharska, E.M., Hara, H., Penninger, J.M., Domashenz, H., Hong, N.A., Glynne, R.J., Nelms, K.A., Goodnow, C.C. Immunity (2003) [Pubmed]
  4. The MAGUK family protein CARD11 is essential for lymphocyte activation. Hara, H., Wada, T., Bakal, C., Kozieradzki, I., Suzuki, S., Suzuki, N., Nghiem, M., Griffiths, E.K., Krawczyk, C., Bauer, B., D'Acquisto, F., Ghosh, S., Yeh, W.C., Baier, G., Rottapel, R., Penninger, J.M. Immunity (2003) [Pubmed]
  5. The activation of lymphocytes is in their CARMA. Abbas, A.K., Sen, R. Immunity (2003) [Pubmed]
  6. Mice lacking the CARD of CARMA1 exhibit defective B lymphocyte development and impaired proliferation of their B and T lymphocytes. Newton, K., Dixit, V.M. Curr. Biol. (2003) [Pubmed]
  7. Potential role of CARMA1 in CD40-induced splenic B cell proliferation and marginal zone B cell maturation. Pappu, B.P., Lin, X. Eur. J. Immunol. (2006) [Pubmed]
  8. Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Egawa, T., Albrecht, B., Favier, B., Sunshine, M.J., Mirchandani, K., O'Brien, W., Thome, M., Littman, D.R. Curr. Biol. (2003) [Pubmed]
  9. CARMA3/Bcl10/MALT1-dependent NF-{kappa}B activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells. McAllister-Lucas, L.M., Ruland, J., Siu, K., Jin, X., Gu, S., Kim, D.S., Kuffa, P., Kohrt, D., Mak, T.W., Nu??ez, G., Lucas, P.C. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  10. The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse. Hara, H., Bakal, C., Wada, T., Bouchard, D., Rottapel, R., Saito, T., Penninger, J.M. J. Exp. Med. (2004) [Pubmed]
  11. Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Gross, O., Gewies, A., Finger, K., Schäfer, M., Sparwasser, T., Peschel, C., Förster, I., Ruland, J. Nature (2006) [Pubmed]
  12. Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1. Niiro, H., Clark, E.A. Immunity (2003) [Pubmed]
WikiGenes - Universities