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Gene Review:

Disc1 - disrupted in schizophrenia 1

Mus musculus

Synonyms: Disrupted in schizophrenia 1 homolog

Austin, C.P. et al., Ishizuka, K. et al., Clapcote, S.J. et al., Sawamura, N. et al.

Clapcote, Roder,

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Psychiatry related information on Disc1

Disrupted-In-Schizophrenia-1 (DISC1) is a promising candidate gene for schizophrenia (SZ) and bipolar disorder (BP), but its basic biology remains to be elucidated [1].

High impact information on Disc1

Disrupted-In-Schizophrenia-1, preferentially expressed in the forebrain, has multiple isoforms with potential posttranslational modifications [1].
These results demonstrate that Disc1 marks the hippocampus from its earliest stages, and suggest that developmental Disc1 dysfunction may lead to defects in hippocampal function that are associated with schizophrenia [2].
Disc1 mRNA was detected in the dentate gyrus at all stages in which this structure was identifiable, as well as in the cornu ammonis (CA) fields of the hippocampus, the subiculum and adjacent entorhinal cortex, and the developing cerebral neocortex, hypothalamus, and olfactory bulbs, all of which also express Disc1 in the adult mouse brain [2].
In addition, Disc1 mRNA was seen in regions of the developing mouse brain which do not express Disc1 during adulthood, regions including the bed nucleus of the stria terminalis, reticular thalamic nucleus and reuniens thalamic nucleus [2].
Disrupted-in-Schizophrenia-1 (DISC1): A Key Susceptibility Factor for Major Mental Illnesses [3].

Anatomical context of Disc1

Strikingly, Disc1 is strongly expressed in the hippocampus during all stages of hippocampal development, from embryonic day 14 through adulthood [2].
Studies from our laboratory have shown that Disc1, the mouse ortholog of DISC1, is highly expressed in the dentate gyrus of the hippocampus in the adult mouse brain [2].

Analytical, diagnostic and therapeutic context of Disc1

Deletion polymorphism of Disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function [4].

References

A review of Disrupted-In-Schizophrenia-1 (DISC1): neurodevelopment, cognition, and mental conditions. Ishizuka, K., Paek, M., Kamiya, A., Sawa, A. Biol. Psychiatry (2006) [Pubmed]
Expression of Disrupted-In-Schizophrenia-1, a schizophrenia-associated gene, is prominent in the mouse hippocampus throughout brain development. Austin, C.P., Ky, B., Ma, L., Morris, J.A., Shughrue, P.J. Neuroscience (2004) [Pubmed]
Disrupted-in-Schizophrenia-1 (DISC1): A Key Susceptibility Factor for Major Mental Illnesses. Sawamura, N., Sawa, A. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
Deletion polymorphism of Disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function. Clapcote, S.J., Roder, J.C. Genetics (2006) [Pubmed]

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