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Gene Review

Disc1  -  disrupted in schizophrenia 1

Mus musculus

Synonyms: Disrupted in schizophrenia 1 homolog
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Psychiatry related information on Disc1

  • Disrupted-In-Schizophrenia-1 (DISC1) is a promising candidate gene for schizophrenia (SZ) and bipolar disorder (BP), but its basic biology remains to be elucidated [1].

High impact information on Disc1


Anatomical context of Disc1

  • Strikingly, Disc1 is strongly expressed in the hippocampus during all stages of hippocampal development, from embryonic day 14 through adulthood [2].
  • Studies from our laboratory have shown that Disc1, the mouse ortholog of DISC1, is highly expressed in the dentate gyrus of the hippocampus in the adult mouse brain [2].

Analytical, diagnostic and therapeutic context of Disc1

  • Deletion polymorphism of Disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function [4].


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