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Gene Review

Disc1  -  disrupted in schizophrenia 1

Rattus norvegicus

Synonyms: Disrupted in schizophrenia 1 homolog
 
 
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Disease relevance of Disc1

 

High impact information on Disc1

  • Disrupted-In-Schizophrenia-1 (DISC1), originally identified at the breakpoint of a chromosomal translocation that is linked to a rare familial schizophrenia, has been genetically implicated in schizophrenia in other populations [2].
  • Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth [3].
  • 9. Disc gel electrophoresis in presence of 0.1% sodium dodecylsulfate yielded a homogeneous preparation [4].
  • METHODS: Disc material was harvested during surgery from herniated and nonherniated portions in patients undergoing elective lumbar disc surgery and subjected to immunohistochemistry and high-performance liquid chromatography for assessment of the presence of extracellular disc matrix glutamate [5].
  • METHODS: Disc herniation was induced in the tails of 112 Wistar rats, using a fixation device between the 5th and 8th coccygeal vertebrae [6].

References

  1. Partial purification and immunological aspects of carboxylesterase from rat liver microsomes. Ishitani, R., Kin, H., Kuwae, T., Moroi, K., Satoh, T. Jpn. J. Pharmacol. (1979) [Pubmed]
  2. A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Kamiya, A., Kubo, K., Tomoda, T., Takaki, M., Youn, R., Ozeki, Y., Sawamura, N., Park, U., Kudo, C., Okawa, M., Ross, C.A., Hatten, M.E., Nakajima, K., Sawa, A. Nat. Cell Biol. (2005) [Pubmed]
  3. Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. Miyoshi, K., Honda, A., Baba, K., Taniguchi, M., Oono, K., Fujita, T., Kuroda, S., Katayama, T., Tohyama, M. Mol. Psychiatry (2003) [Pubmed]
  4. Purification and properties of a NAD: 3 alpha-hydroxy-5 alpha-pregnan-20-one-oxidoreductase from rat liver microsomes. Golf, S.W., Graef, V. Steroids (1980) [Pubmed]
  5. Herniated lumbar disc material as a source of free glutamate available to affect pain signals through the dorsal root ganglion. Harrington, J.F., Messier, A.A., Bereiter, D., Barnes, B., Epstein, M.H. Spine. (2000) [Pubmed]
  6. Percutaneous reinsertion of the nucleus pulposus. An experimental study. Nishimura, K., Mochida, J. Spine. (1998) [Pubmed]
 
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