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Gene Review

Zfp354a  -  zinc finger protein 354A

Rattus norvegicus

Synonyms: Kid1, Kidney, ischemia, and developmentally-regulated protein 1, Renal transcription factor Kid-1, TCF-17, Tcf17, ...
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Disease relevance of Zfp354a

  • We have identified a new putative transcription factor from the rat kidney, termed Kid-1 (for kidney, ischemia and developmentally regulated gene 1) [1].
  • Kid-1 mRNA levels are also reduced in rodent renal cell carcinomas, another condition characterized by epithelial cell dedifferentiation and increased proliferation [2].

High impact information on Zfp354a

  • Kid-1 belongs to the C2H2 class of zinc finger genes [1].
  • The low expression of Kid-1 early in postnatal development, and when renal tissue is recovering after injury, suggests that the gene product is involved in establishment of a differentiated phenotype and/or regulation of the proliferative response [1].
  • Kid-1 mRNA levels decline after renal injury secondary to ischemia or folic acid administration, two insults which result in epithelial cell dedifferentiation, followed by regenerative hyperplasia and differentiation [1].
  • The full-length Kid-1 protein is targeted to the nucleolus and adheres tightly to as yet undefined nucleolar structures, leading eventually to the disintegration of the nucleolus [3].
  • The rat Kid-1 gene codes for a 66-kDa protein with KRAB domains at the NH2 terminus and two Cys2His2-zinc finger clusters of four and nine zinc fingers at the COOH terminus [3].

Biological context of Zfp354a


Anatomical context of Zfp354a


Other interactions of Zfp354a


  1. Kid-1, a putative renal transcription factor: regulation during ontogeny and in response to ischemia and toxic injury. Witzgall, R., O'Leary, E., Gessner, R., Ouellette, A.J., Bonventre, J.V. Mol. Cell. Biol. (1993) [Pubmed]
  2. Kid-1 expression is high in differentiated renal proximal tubule cells and suppressed in cyst epithelia. Witzgall, R., Obermüller, N., Bölitz, U., Calvet, J.P., Cowley, B.D., Walker, C., Kriz, W., Gretz, N., Bonventre, J.V. Am. J. Physiol. (1998) [Pubmed]
  3. Expression of the transcriptional repressor protein Kid-1 leads to the disintegration of the nucleolus. Huang, Z., Philippin, B., O'Leary, E., Bonventre, J.V., Kriz, W., Witzgall, R. J. Biol. Chem. (1999) [Pubmed]
  4. Genomic structure and chromosomal location of the rat gene encoding the zinc finger transcription factor Kid-1. Witzgall, R., Volk, R., Yeung, R.S., Bonventre, J.V. Genomics (1994) [Pubmed]
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