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Gene Review

ZNF354A  -  zinc finger protein 354A

Homo sapiens

Synonyms: EZNF, HEL104, HKL1, KID-1, KID1, ...
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Disease relevance of ZNF354A


High impact information on ZNF354A


Biological context of ZNF354A

  • We found ubiquitous expression of human Tcf17 as well as rat Kid-1 in different types of human and rat tissue, indicating that the putative transcription-regulating activity of this zinc finger gene, in contrast to the published data, is not restricted to the kidney [1].
  • The human Kid-1 homolog Tcf17 has been cloned and assigned to chromosome 5q35 [1].
  • The deduced amino acid sequence showed 86.0% and 87.2% identity (91.6% and 92.8% similarity) with the rat Kid1 and mouse Tcf17 respectively [3].
  • KID1 is a putative transcriptional repressor, containing a KRAB domain at its amino terminus that mediates transcriptional repression in transient cell transfection assays when fused to a heterologous DNA-binding domain [4].

Associations of ZNF354A with chemical compounds


Analytical, diagnostic and therapeutic context of ZNF354A

  • Northern blot analysis indicated that HKL-1 clone hybridizes with mRNA of about 0.5 kb, consistent with the size of the HKL-1 clone [5].


  1. The tcf17 gene at chromosome 5q is not involved in the development of conventional renal cell carcinoma. Bugert, P., Pesti, T., Kovacs, G. Int. J. Cancer (2000) [Pubmed]
  2. Differential expression of the zinc finger gene TCF17 in testicular tumors. Przyborski, S.A., Damjanov, I., Knowles, B.B., Ackerman, S.L. Cancer Res. (1998) [Pubmed]
  3. Cloning, expression and mapping of a novel human zinc-finger gene TCF17 homologous to rodent Kid1. Omori, Y., Kyushiki, H., Takeda, S., Suzuki, M., Kawai, A., Fujiwara, T., Takahashi, E., Nakamura, Y. Cytogenet. Cell Genet. (1997) [Pubmed]
  4. Characterization of the mouse Kid1 gene and identification of a highly related gene, Kid2. Tekki-Kessaris, N., Bonventre, J.V., Boulter, C.A. Gene (1999) [Pubmed]
  5. Cloning of human keratolinin cDNA: keratolinin is identical with a cysteine proteinase inhibitor, cystatin A, and is regulated by Ca2+, TPA, and cAMP. Takahashi, H., Kinouchi, M., Wuepper, K.D., Iizuka, H. J. Invest. Dermatol. (1997) [Pubmed]
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