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Gene Review

Aggr1  -  aggression 1

Mus musculus

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Disease relevance of Aggr1

  • Hypotension could not be elicited by Aggr. in rats pretreated with GdCl3 [1].

High impact information on Aggr1

  • Recent experiments to dissect male aggressive behaviour in Drosophila melanogaster, using gene expression analysis of selected lines followed by mutant analysis, have identified new candidate genes associated with male aggression, including one strong candidate that encodes a cytochrome P450 enzyme [2].
  • A 20-Mb Region of Chromosome 4 Controls TNF-{alpha}-Mediated CD8+ T Cell Aggression Toward beta Cells in Type 1 Diabetes [3].
  • Reduced aggression in mice lacking GABA transporter subtype 1 [4].
  • After postnatal exposure, reduced Immobility with increased Social Investigation and Explore and Scan occurred at 5 and 15 weeks, at 25 weeks valproate increased Social Investigation in males encountering females and at 30 weeks enhanced Aggression in pair-housed males [5].
  • Our results imply complex interplay between parental genotypes in anxiety, activity, grooming, aggression and barbering of their F1 progeny, further confirming the utility of F1 hybrids in behavioral neurogenetics [6].

Biological context of Aggr1

  • We took advantage of the large phenotypic difference between these strains and used an outcross-backcross breeding protocol and a genome-wide scan to identify aggression quantitative trait loci (QTLs) on distal chromosome 10 (Aggr1; p = 6 x 10(-7)) and proximal chromosome X (Aggr2; p = 2.14 x 10(-5)) [7].
  • Infusion of PTX immediately prior to Aggr. administration prevented the drop of blood pressure [1].
  • The genetics that underlie variation in amygdala structure may be coupled to variation in levels of aggression, fear, anxiety, and affiliated behaviors [8].

Associations of Aggr1 with chemical compounds


  1. Comparison of hypotensive response to aggregated IgG or to bacterial LPS in rats. Jenei, B., Pócsik, E., Lázár, G., Medgyesi, G.A. Inflamm. Res. (1997) [Pubmed]
  2. Fighting fly genes. Robin, C., Daborn, P.J., Hoffmann, A.A. Trends Genet. (2007) [Pubmed]
  3. A 20-Mb Region of Chromosome 4 Controls TNF-{alpha}-Mediated CD8+ T Cell Aggression Toward beta Cells in Type 1 Diabetes. Chamberlain, G., W??llberg, M., Rainbow, D., Hunter, K., Wicker, L.S., Green, E.A. J. Immunol. (2006) [Pubmed]
  4. Reduced aggression in mice lacking GABA transporter subtype 1. Liu, G.X., Liu, S., Cai, G.Q., Sheng, Z.J., Cai, Y.Q., Jiang, J., Sun, X., Ma, S.K., Wang, L., Wang, Z.G., Fei, J. J. Neurosci. Res. (2007) [Pubmed]
  5. Sodium valproate: effects on social behaviour and physical development in the mouse. Chapman, J.B., Cutler, M.G. Psychopharmacology (Berl.) (1984) [Pubmed]
  6. Influence of paternal genotypes on F1 behaviors: Lessons from several mouse strains. Kalueff, A.V., Keisala, T., Minasyan, A., Tuohimaa, P. Behav. Brain Res. (2007) [Pubmed]
  7. Identification of quantitative trait Loci that affect aggressive behavior in mice. Brodkin, E.S., Goforth, S.A., Keene, A.H., Fossella, J.A., Silver, L.M. J. Neurosci. (2002) [Pubmed]
  8. Genetic and Structural Analysis of the Basolateral Amygdala Complex in BXD Recombinant Inbred Mice. Mozhui, K., Hamre, K.M., Holmes, A., Lu, L., Williams, R.W. Behav. Genet. (2007) [Pubmed]
  9. Catecholamines and Aggression: The Role of COMT and MAO Polymorphisms. Volavka, J., Bilder, R., Nolan, K. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
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