The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Fcgr4  -  Fc receptor, IgG, low affinity IV

Mus musculus

Synonyms: 4833442P21Rik, CD16-2, FcgRIV, FcgammaRIV, Fcgr3a, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Fcgr4

 

High impact information on Fcgr4

  • FcgammaRIV maps in the 75 kb genomic interval between FcgammaRII and FcgammaRIII; its expression is restricted to myeloid lineage cells, and it binds to IgG2a and IgG2b with intermediate affinity [1].
  • These enhanced activities result, in part, from their ability to bind to a novel, gamma chain-dependent, activating IgG Fc receptor, FcgammaRIV [1].
  • The potency of IgG2a/c CD20 mAbs resulted from FcgammaRIV interactions, with potential contributions from high-affinity FcgammaRI [2].
  • The pathology observed in this model is determined by the effector cell activation threshold that is established by the coexpression on infiltrating macrophages of the IgG2a/2b restricted activation receptor FcgammaRIV and its inhibitory receptor counterpart, FcgammaRIIB [3].
  • Here we show that immunoglobulin (Ig)G2a and 2b autoantibodies are the pathogenic isotypes by recruiting FcgammaRIV expressing macrophages [4].
 

Anatomical context of Fcgr4

 

Physical interactions of Fcgr4

 

Regulatory relationships of Fcgr4

 

Other interactions of Fcgr4

References

  1. FcgammaRIV: a novel FcR with distinct IgG subclass specificity. Nimmerjahn, F., Bruhns, P., Horiuchi, K., Ravetch, J.V. Immunity (2005) [Pubmed]
  2. Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy. Hamaguchi, Y., Xiu, Y., Komura, K., Nimmerjahn, F., Tedder, T.F. J. Exp. Med. (2006) [Pubmed]
  3. Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptors. Kaneko, Y., Nimmerjahn, F., Madaio, M.P., Ravetch, J.V. J. Exp. Med. (2006) [Pubmed]
  4. TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. Ehlers, M., Fukuyama, H., McGaha, T.L., Aderem, A., Ravetch, J.V. J. Exp. Med. (2006) [Pubmed]
  5. Identification of CD16-2, a novel mouse receptor homologous to CD16/Fc gamma RIII. Mechetina, L.V., Najakshin, A.M., Alabyev, B.Y., Chikaev, N.A., Taranin, A.V. Immunogenetics (2002) [Pubmed]
  6. Fcgamma receptor-dependent effector mechanisms regulate CD19 and CD20 antibody immunotherapies for B lymphocyte malignancies and autoimmunity. Tedder, T.F., Baras, A., Xiu, Y. Springer Semin. Immunopathol. (2006) [Pubmed]
  7. Critical Role of the Fc Receptor {gamma}-Chain on APCs in the Development of Allergen-Induced Airway Hyperresponsiveness and Inflammation. Kitamura, K., Takeda, K., Koya, T., Miyahara, N., Kodama, T., Dakhama, A., Takai, T., Hirano, A., Tanimoto, M., Harada, M., Gelfand, E.W. J. Immunol. (2007) [Pubmed]
  8. Critical but overlapping role of FcgammaRIII and FcgammaRIV in activation of murine neutrophils by immobilized immune complexes. Jakus, Z., Németh, T., Verbeek, J.S., Mócsai, A. J. Immunol. (2008) [Pubmed]
 
WikiGenes - Universities