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Gene Review

Fcgr4  -  Fc receptor, IgG, low affinity IV

Mus musculus

Synonyms: 4833442P21Rik, CD16-2, FcgRIV, FcgammaRIV, Fcgr3a, ...
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Disease relevance of Fcgr4


High impact information on Fcgr4

  • FcgammaRIV maps in the 75 kb genomic interval between FcgammaRII and FcgammaRIII; its expression is restricted to myeloid lineage cells, and it binds to IgG2a and IgG2b with intermediate affinity [1].
  • These enhanced activities result, in part, from their ability to bind to a novel, gamma chain-dependent, activating IgG Fc receptor, FcgammaRIV [1].
  • The potency of IgG2a/c CD20 mAbs resulted from FcgammaRIV interactions, with potential contributions from high-affinity FcgammaRI [2].
  • The pathology observed in this model is determined by the effector cell activation threshold that is established by the coexpression on infiltrating macrophages of the IgG2a/2b restricted activation receptor FcgammaRIV and its inhibitory receptor counterpart, FcgammaRIIB [3].
  • Here we show that immunoglobulin (Ig)G2a and 2b autoantibodies are the pathogenic isotypes by recruiting FcgammaRIV expressing macrophages [4].

Anatomical context of Fcgr4


Physical interactions of Fcgr4


Regulatory relationships of Fcgr4


Other interactions of Fcgr4


  1. FcgammaRIV: a novel FcR with distinct IgG subclass specificity. Nimmerjahn, F., Bruhns, P., Horiuchi, K., Ravetch, J.V. Immunity (2005) [Pubmed]
  2. Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy. Hamaguchi, Y., Xiu, Y., Komura, K., Nimmerjahn, F., Tedder, T.F. J. Exp. Med. (2006) [Pubmed]
  3. Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptors. Kaneko, Y., Nimmerjahn, F., Madaio, M.P., Ravetch, J.V. J. Exp. Med. (2006) [Pubmed]
  4. TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. Ehlers, M., Fukuyama, H., McGaha, T.L., Aderem, A., Ravetch, J.V. J. Exp. Med. (2006) [Pubmed]
  5. Identification of CD16-2, a novel mouse receptor homologous to CD16/Fc gamma RIII. Mechetina, L.V., Najakshin, A.M., Alabyev, B.Y., Chikaev, N.A., Taranin, A.V. Immunogenetics (2002) [Pubmed]
  6. Fcgamma receptor-dependent effector mechanisms regulate CD19 and CD20 antibody immunotherapies for B lymphocyte malignancies and autoimmunity. Tedder, T.F., Baras, A., Xiu, Y. Springer Semin. Immunopathol. (2006) [Pubmed]
  7. Critical Role of the Fc Receptor {gamma}-Chain on APCs in the Development of Allergen-Induced Airway Hyperresponsiveness and Inflammation. Kitamura, K., Takeda, K., Koya, T., Miyahara, N., Kodama, T., Dakhama, A., Takai, T., Hirano, A., Tanimoto, M., Harada, M., Gelfand, E.W. J. Immunol. (2007) [Pubmed]
  8. Critical but overlapping role of FcgammaRIII and FcgammaRIV in activation of murine neutrophils by immobilized immune complexes. Jakus, Z., Németh, T., Verbeek, J.S., Mócsai, A. J. Immunol. (2008) [Pubmed]
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