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Gene Review

Slc22a1  -  solute carrier family 22 (organic cation...

Rattus norvegicus

Synonyms: Oct1, Orct1, Organic cation transporter 1, Roct1, Solute carrier family 22 member 1, ...
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High impact information on Slc22a1

  • The liver plays a major role in biotransformation and elimination of various therapeutic agents and xenobiotics, many of which are organic cations and substrates of the organic cation transporter 1 (Oct1, Slc22a1) [1].
  • Nuclear extracts from PC12 cells contained a protein (or proteins) specifically binding the octamer sequence, and supershift experiments with anti-Oct-1 indicated involvement of this ubiquitously expressed transcription factor in the complex [2].
  • An octamer 1 (Oct-1) binding site, located between positions -166 and -159 was shown by deletion analysis and site-directed mutation to be critical for promoter activity [2].
  • Roct1, a rat polyspecific transporter gene for the excretion of cationic drugs, maps to chromosome 1q11-12 [3].
  • Heat shock treatment suppresses angiotensin II-induced SP-1 and AP-1 and stimulates Oct-1 DNA-binding activity in heart [4].

Biological context of Slc22a1


Regulatory relationships of Slc22a1

  • In addition, HS increased Oct-1 activity that was suppressed by Ang II infusion [4].

Other interactions of Slc22a1

  • In this study we examined pro-inflammatory transcription factors SP-1, AP-1 and an anti-inflammatory cytokine transcriptional repressor, Oct-1, DNA-binding activities after chronic Ang II infusion and the effect of HS treatment on these pathways in heart [4].


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