Gene Review:
SLC22A1 - solute carrier family 22 (organic cation...
Homo sapiens
Synonyms:
HOCT1, OCT1, Organic cation transporter 1, Solute carrier family 22 member 1, hOCT1, ...
- Analysis of octamer-binding transcription factors Oct2 and Oct1 and their coactivator BOB.1/OBF.1 in lymphomas. Sáez, A.I., Artiga, M.J., Sánchez-Beato, M., Sánchez-Verde, L., García, J.F., Camacho, F.I., Franco, R., Piris, M.A. Mod. Pathol. (2002)
- Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system. Zhang, L., Gorset, W., Washington, C.B., Blaschke, T.F., Kroetz, D.L., Giacomini, K.M. Drug Metab. Dispos. (2000)
- OBF1 enhances transcriptional potential of Oct1. Lins, K., Reményi, A., Tomilin, A., Massa, S., Wilmanns, M., Matthias, P., Schöler, H.R. EMBO J. (2003)
- Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease. Theuns, J., Brouwers, N., Engelborghs, S., Sleegers, K., Bogaerts, V., Corsmit, E., De Pooter, T., van Duijn, C.M., De Deyn, P.P., Van Broeckhoven, C. Am. J. Hum. Genet. (2006)
- Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1. Shu, Y., Leabman, M.K., Feng, B., Mangravite, L.M., Huang, C.C., Stryke, D., Kawamoto, M., Johns, S.J., DeYoung, J., Carlson, E., Ferrin, T.E., Herskowitz, I., Giacomini, K.M. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions. Sakata, T., Anzai, N., Shin, H.J., Noshiro, R., Hirata, T., Yokoyama, H., Kanai, Y., Endou, H. Biochem. Biophys. Res. Commun. (2004)
- The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26. Koehler, M.R., Wissinger, B., Gorboulev, V., Koepsell, H., Schmid, M. Cytogenet. Cell Genet. (1997)
- Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3). Bourdet, D.L., Pritchard, J.B., Thakker, D.R. J. Pharmacol. Exp. Ther. (2005)
- Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. Lips, K.S., Volk, C., Schmitt, B.M., Pfeil, U., Arndt, P., Miska, D., Ermert, L., Kummer, W., Koepsell, H. Am. J. Respir. Cell Mol. Biol. (2005)
- Drug specificity and intestinal membrane localization of human organic cation transporters (OCT). Müller, J., Lips, K.S., Metzner, L., Neubert, R.H., Koepsell, H., Brandsch, M. Biochem. Pharmacol. (2005)
- Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2. Ciarimboli, G., Ludwig, T., Lang, D., Pavenstädt, H., Koepsell, H., Piechota, H.J., Haier, J., Jaehde, U., Zisowsky, J., Schlatter, E. Am. J. Pathol. (2005)
- Enhanced expression of the human vacuolar H+-ATPase c subunit gene (ATP6L) in response to anticancer agents. Torigoe, T., Izumi, H., Ishiguchi, H., Uramoto, H., Murakami, T., Ise, T., Yoshida, Y., Tanabe, M., Nomoto, M., Itoh, H., Kohno, K. J. Biol. Chem. (2002)
- Cisplatin and Oxaliplatin, but Not Carboplatin and Nedaplatin, Are Substrates for Human Organic Cation Transporters (SLC22A1-3 and Multidrug and Toxin Extrusion Family). Yonezawa, A., Masuda, S., Yokoo, S., Katsura, T., Inui, K. J. Pharmacol. Exp. Ther. (2006)
- Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1). Hayer, M., Bönisch, H., Brüss, M. Ann. Hum. Genet. (1999)
- Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes. Jigorel, E., Le Vee, M., Boursier-Neyret, C., Parmentier, Y., Fardel, O. Drug Metab. Dispos. (2006)
- Active transport of imatinib into and out of cells: implications for drug resistance. Thomas, J., Wang, L., Clark, R.E., Pirmohamed, M. Blood (2004)
- Cloning and functional expression of a human liver organic cation transporter. Zhang, L., Dresser, M.J., Gray, A.T., Yost, S.C., Terashita, S., Giacomini, K.M. Mol. Pharmacol. (1997)
- Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. Verhaagh, S., Schweifer, N., Barlow, D.P., Zwart, R. Genomics (1999)
- Norepinephrine transport by the extraneuronal monoamine transporter in human bronchial arterial smooth muscle cells. Horvath, G., Sutto, Z., Torbati, A., Conner, G.E., Salathe, M., Wanner, A. Am. J. Physiol. Lung Cell Mol. Physiol. (2003)
- The Human Organic Cation Transporter-1 Gene Is Transactivated by Hepatocyte Nuclear Factor-4{alpha}. Saborowski, M., Kullak-Ublick, G.A., Eloranta, J.J. J. Pharmacol. Exp. Ther. (2006)
- Cloning and characterization of two human polyspecific organic cation transporters. Gorboulev, V., Ulzheimer, J.C., Akhoundova, A., Ulzheimer-Teuber, I., Karbach, U., Quester, S., Baumann, C., Lang, F., Busch, A.E., Koepsell, H. DNA Cell Biol. (1997)
- Enantioselective binding to the human organic cation transporter-1 (hOCT1) determined using an immobilized hOCT1 liquid chromatographic stationary phase. Moaddel, R., Patel, S., Jozwiak, K., Yamaguchi, R., Ho, P.C., Wainer, I.W. Chirality. (2005)