The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Selk  -  selenoprotein K

Rattus norvegicus

Synonyms: SelK, Selenoprotein K
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of LOC290549


Psychiatry related information on LOC290549


High impact information on LOC290549


Chemical compound and disease context of LOC290549


Biological context of LOC290549


Anatomical context of LOC290549


Associations of LOC290549 with chemical compounds


Physical interactions of LOC290549


Regulatory relationships of LOC290549


Other interactions of LOC290549

  • OBJECTIVE AND DESIGN: Heat shock (HS) treatment (42 degrees C for 15 min) and the expression of heat shock proteins (Hsps) protect against angiotensin (Ang) II-induced inflammation in aorta and heart by suppressing the activation of the pro-inflammatory transcription factor NF-kappaB [37].
  • Heat shock protein 90alpha-dependent translocation of annexin II to the surface of endothelial cells modulates plasmin activity in the diabetic rat aorta [38].
  • Heat shock led to a decrease in liver superoxide dismutase (SOD) activity at 1 hour in the antioxidant-supplemented group, but this was unchanged in the liver of all other groups and in the skin [39].
  • Heat shock protein 27 shows a distinctive widespread spatial and temporal pattern of induction in CNS glial and neuronal cells compared to heat shock protein 70 and caspase 3 following kainate administration [40].
  • Heat shock treatment resulted in an increased number of the cells exhibiting a nuclear location of 100 kDa [41].

Analytical, diagnostic and therapeutic context of LOC290549


  1. Specific induction of the 70-kD heat stress proteins by the tyrosine kinase inhibitor herbimycin-A protects rat neonatal cardiomyocytes. A new pharmacological route to stress protein expression? Morris, S.D., Cumming, D.V., Latchman, D.S., Yellon, D.M. J. Clin. Invest. (1996) [Pubmed]
  2. Heat shock protects cultured neurons from glutamate toxicity. Rordorf, G., Koroshetz, W.J., Bonventre, J.V. Neuron (1991) [Pubmed]
  3. Heat shock response in the liver: expression and regulation of the hsp70 gene family and early response genes after in vivo hyperthermia. Schiaffonati, L., Tacchini, L., Pappalardo, C. Hepatology (1994) [Pubmed]
  4. Analysis of K+ and Na+ transport and intracellular contents during and after heat shock and their role in protein synthesis in rat hepatoma cells. Boonstra, J., Schamhart, D.H., de Laat, S.W., van Wijk, R. Cancer Res. (1984) [Pubmed]
  5. Regulation of the synthesis of superoxide dismutases in rat lungs during oxidant and hyperthermic stresses. Hass, M.A., Massaro, D. J. Biol. Chem. (1988) [Pubmed]
  6. Regulation of aldose reductase, sorbitol dehydrogenase, and taurine cotransporter mRNA in rat medulla. Martial, S., Price, S.R., Sands, J.M. J. Am. Soc. Nephrol. (1995) [Pubmed]
  7. Heat shock induces rapid dephosphorylation of tau in both female and male rats followed by hyperphosphorylation only in female rats: implications for Alzheimer's disease. Papasozomenos, S.C. J. Neurochem. (1996) [Pubmed]
  8. Adrenergic receptors mediate stress-induced elevations in extracellular Hsp72. Johnson, J.D., Campisi, J., Sharkey, C.M., Kennedy, S.L., Nickerson, M., Fleshner, M. J. Appl. Physiol. (2005) [Pubmed]
  9. Heat shock is lethal to fibroblasts microinjected with antibodies against hsp70. Riabowol, K.T., Mizzen, L.A., Welch, W.J. Science (1988) [Pubmed]
  10. Heat shock protein 70 prevents secretagogue-induced cell injury in the pancreas by preventing intracellular trypsinogen activation. Bhagat, L., Singh, V.P., Hietaranta, A.J., Agrawal, S., Steer, M.L., Saluja, A.K. J. Clin. Invest. (2000) [Pubmed]
  11. Heat shock induces resistance in rat pancreatic islet cells against nitric oxide, oxygen radicals and streptozotocin toxicity in vitro. Bellmann, K., Wenz, A., Radons, J., Burkart, V., Kleemann, R., Kolb, H. J. Clin. Invest. (1995) [Pubmed]
  12. Catalase inhibition with 3-amino-1,2,4-triazole does not abolish infarct size reduction in heat-shocked rats. Auyeung, Y., Sievers, R.E., Weng, D., Barbosa, V., Wolfe, C.L. Circulation (1995) [Pubmed]
  13. Heat shock response and cytotoxicity in C6 rat glioma cells: structure-activity relationship of different alcohols. Neuhaus-Steinmetz, U., Xu, C., Fracella, F., Oberheitmann, B., Richter-Landsberg, C., Rensing, L. Mol. Pharmacol. (1994) [Pubmed]
  14. Lipopolysaccharide pretreatment attenuates myocardial infarct size: A possible mechanism involving heat shock protein 70-inhibitory kappaBalpha complex and attenuation of nuclear factor kappaB. Shimizu, M., Tamamori-Adachi, M., Arai, H., Tabuchi, N., Tanaka, H., Sunamori, M. J. Thorac. Cardiovasc. Surg. (2002) [Pubmed]
  15. Heat shock treatment protects against angiotensin II-induced hypertension and inflammation in aorta. Chen, Y., Ross, B.M., Currie, R.W. Cell Stress Chaperones (2004) [Pubmed]
  16. Heat shock protein 27 delivered via a herpes simplex virus vector can protect neurons of the hippocampus against kainic-acid-induced cell loss. Kalwy, S.A., Akbar, M.T., Coffin, R.S., de Belleroche, J., Latchman, D.S. Brain Res. Mol. Brain Res. (2003) [Pubmed]
  17. Heat shock- and ethanol-induced ionic changes in C6 rat glioma cells determined by NMR and fluorescence spectroscopy. Skrandies, S., Bremer, B., Pilatus, U., Mayer, A., Neuhaus-Steinmetz, U., Rensing, L. Brain Res. (1997) [Pubmed]
  18. The temporal profile of 72-kDa heat-shock protein expression following global ischemia. Simon, R.P., Cho, H., Gwinn, R., Lowenstein, D.H. J. Neurosci. (1991) [Pubmed]
  19. Implication of a small GTPase Rac1 in the activation of c-Jun N-terminal kinase and heat shock factor in response to heat shock. Han, S.I., Oh, S.Y., Woo, S.H., Kim, K.H., Kim, J.H., Kim, H.D., Kang, H.S. J. Biol. Chem. (2001) [Pubmed]
  20. Heat shock protein 70 is able to prevent heat shock-induced resistance of target cells to CTL. Dressel, R., Elsner, L., Quentin, T., Walter, L., Günther, E. J. Immunol. (2000) [Pubmed]
  21. Heat shock and oxidative stress-induced exposure of hydrophobic protein domains as common signal in the induction of hsp68. Gosslau, A., Ruoff, P., Mohsenzadeh, S., Hobohm, U., Rensing, L. J. Biol. Chem. (2001) [Pubmed]
  22. Heat shock protein expression in vulnerable cells of the rat hippocampus as an indicator of excitation-induced neuronal stress. Sloviter, R.S., Lowenstein, D.H. J. Neurosci. (1992) [Pubmed]
  23. Heat shock protein 27: developmental regulation and expression after peripheral nerve injury. Costigan, M., Mannion, R.J., Kendall, G., Lewis, S.E., Campagna, J.A., Coggeshall, R.E., Meridith-Middleton, J., Tate, S., Woolf, C.J. J. Neurosci. (1998) [Pubmed]
  24. Heat shock response inhibits cytokine-inducible nitric oxide synthase expression in rat hepatocytes. de Vera, M.E., Kim, Y.M., Wong, H.R., Wang, Q., Billiar, T.R., Geller, D.A. Hepatology (1996) [Pubmed]
  25. Insulin deficiency downregulated heat shock protein 60 and IGF-1 receptor signaling in diabetic myocardium. Chen, H.S., Shan, Y.X., Yang, T.L., Lin, H.D., Chen, J.W., Lin, S.J., Wang, P.H. Diabetes (2005) [Pubmed]
  26. Heat shock protein 65-reactive T cells are involved in the pathogenesis of non-antigenic dimethyl dioctadecyl ammonium bromide-induced arthritis. Mia, M.Y., Durai, M., Kim, H.R., Moudgil, K.D. J. Immunol. (2005) [Pubmed]
  27. Heat shock suppresses the permeability transition in rat liver mitochondria. He, L., Lemasters, J.J. J. Biol. Chem. (2003) [Pubmed]
  28. Phosphorylation-dependent cellular localization and thermoprotective role of heat shock protein 25 in hippocampal progenitor cells. Geum, D., Son, G.H., Kim, K. J. Biol. Chem. (2002) [Pubmed]
  29. Heat shock prevents lipopolysaccharide-induced tumor necrosis factor-alpha synthesis by rat mononuclear phagocytes. Fouqueray, B., Philippe, C., Amrani, A., Perez, J., Baud, L. Eur. J. Immunol. (1992) [Pubmed]
  30. Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell. Sepehrnia, B., Paz, I.B., Dasgupta, G., Momand, J. J. Biol. Chem. (1996) [Pubmed]
  31. Characterization of the hydrophobic region of heat shock protein 90. Yamamoto, M., Takahashi, Y., Inano, K., Horigome, T., Sugano, H. J. Biochem. (1991) [Pubmed]
  32. Heat shock-induced attenuation of hydroxyl radical generation and mitochondrial aconitase activity in cardiac H9c2 cells. Ilangovan, G., Venkatakrishnan, C.D., Bratasz, A., Osinbowale, S., Cardounel, A.J., Zweier, J.L., Kuppusamy, P. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  33. Suppression of tumor necrosis factor-alpha production and neutrophil infiltration during ischemia-reperfusion injury of the liver after heat shock preconditioning. Yonezawa, K., Yamamoto, Y., Yamamoto, H., Ishikawa, Y., Uchinami, H., Taura, K., Nakajima, A., Yamaoka, Y. J. Hepatol. (2001) [Pubmed]
  34. Heat shock induces neurite outgrowth in PC12m3 cells via the p38 mitogen-activated protein kinase pathway. Kano, Y., Nakagiri, S., Nohno, T., Hiragami, F., Kawamura, K., Kadota, M., Numata, K., Koike, Y., Furuta, T. Brain Res. (2004) [Pubmed]
  35. Heat shock protein 27 delays Ca2+-induced cell death in a caspase-dependent and -independent manner in rat retinal ganglion cells. Whitlock, N.A., Lindsey, K., Agarwal, N., Crosson, C.E., Ma, J.X. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  36. Heat shock inhibits the hypoxia-induced effects on iodide uptake and signal transduction and enhances cell survival in rat thyroid FRTL-5 cells. Kiang, J.G., Wang, X.D., Ding, X.Z., Gist, I.D., Smallridge, R.C. Thyroid (1996) [Pubmed]
  37. Heat shock treatment suppresses angiotensin II-induced SP-1 and AP-1 and stimulates Oct-1 DNA-binding activity in heart. Chen, Y., Currie, R.W. Inflamm. Res. (2005) [Pubmed]
  38. Heat shock protein 90alpha-dependent translocation of annexin II to the surface of endothelial cells modulates plasmin activity in the diabetic rat aorta. Lei, H., Romeo, G., Kazlauskas, A. Circ. Res. (2004) [Pubmed]
  39. Effect of selenium-enriched yeast pretreatment on the antioxidative defense in the skin of rats exposed to heat shock. Korać, B., Buzadzić, B., Saicić, Z.S., Radojicić, R., Petrović, V.M. J. Environ. Pathol. Toxicol. Oncol. (1998) [Pubmed]
  40. Heat shock protein 27 shows a distinctive widespread spatial and temporal pattern of induction in CNS glial and neuronal cells compared to heat shock protein 70 and caspase 3 following kainate administration. Akbar, M.T., Wells, D.J., Latchman, D.S., de Belleroche, J. Brain Res. Mol. Brain Res. (2001) [Pubmed]
  41. Biochemical characterization of the mammalian stress proteins and identification of two stress proteins as glucose- and Ca2+-ionophore-regulated proteins. Welch, W.J., Garrels, J.I., Thomas, G.P., Lin, J.J., Feramisco, J.R. J. Biol. Chem. (1983) [Pubmed]
  42. Heat shock protein induction in rat hearts. A role for improved myocardial salvage after ischemia and reperfusion? Donnelly, T.J., Sievers, R.E., Vissern, F.L., Welch, W.J., Wolfe, C.L. Circulation (1992) [Pubmed]
  43. Differential expression of heat shock protein (HSP70) mRNAs in rat cells. Angeletti, B., Pascale, E., Verna, R., Passarelli, F., Butler, R.H., D'Ambrosio, E. Exp. Cell Res. (1996) [Pubmed]
  44. Heat shock protein 27 in chronic allograft nephropathy: a local stress response. Djamali, A., Reese, S., Oberley, T., Hullett, D., Becker, B. Transplantation (2005) [Pubmed]
  45. An anti-ulcer drug, geranylgeranylacetone, suppresses inducible nitric oxide synthase in cultured vascular smooth muscle cells. Yamamoto, K., Sarukawa, M., Ito, T., Aoki, H., Ichida, M., Shimada, K. J. Hypertens. (2005) [Pubmed]
  46. Induction of a stress protein in developing cell cultures of the rat cerebellum. Pearce, B.R., Dutton, G.R., White, F.P. J. Neurochem. (1983) [Pubmed]
WikiGenes - Universities