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Disease relevance of Plethysmography


Psychiatry related information on Plethysmography


High impact information on Plethysmography


Chemical compound and disease context of Plethysmography

  • METHODS: The forearm blood flow (FBF) was measured in 25 patients with essential hypertension and in 25 normotensive subjects by using strain-gauge plethysmography during reactive hyperemia (RH) (280 mm Hg for 5 min) and after sublingual administration of nitroglycerin (NTG, 0.3 mg) [12].
  • 2. We measured forearm blood flow responses (plethysmography) to isocapnic hypoxia (arterial saturation approximately 85%) in eight healthy men and women (18-26 years) after selective alpha-adrenergic blockade (phentolamine) of one forearm [13].
  • METHODS: In 70 hypertensive patients with electrocardiographic left ventricular hypertrophy, we measured minimal forearm vascular resistance (MFVR) by plethysmography and insulin sensitivity (M/IG) by a 2-h isoglycemic hyperinsulinemic clamp at baseline and after 1, 2 and 3 years of blinded treatment with atenolol- or losartan-based regimens [14].
  • Strain-gauge plethysmography was repeated at the end of heparin treatment, and evaluation of therapy was performed by comparing the indexes of venous hemodynamics and by assessing the incidence of pulmonary embolism and of bleeding complications [15].
  • Breathing pattern was recorded in 4-day-old rats by airflow plethysmography, during normoxia in warm (control) and cold conditions, or during hypoxia (inspired O2 = 10%) in warm or cold conditions, each lasting 15 min [16].

Biological context of Plethysmography


Anatomical context of Plethysmography

  • In 11 healthy humans, we recorded muscle sympathetic nerve activity (MSNA) with microelectrodes (peroneal nerve), as well as blood flow in the forearm and calf (venous occlusion plethysmography) at baseline and during graded LBNP [22].
  • Strain-gauge plethysmography of the lower limbs was used to calculate arterial calf blood flow (RF), arterial calf blood flow after post-ischaemic hyperaemia (PF), basal and minimal vascular resistances (BVR and MVR), time to reach peak flow (tPF), time until 50% reduction of peak flow (tT1/2) and total recovery time (tT) [23].
  • METHODS: Using optoelectronic plethysmography, total and regional chest wall volumes were measured non-invasively in 20 stable patients with COPD (mean (SD) forced expiratory volume in 1 second 43.6 (11.6)% predicted) and dynamic hyperinflation was tracked breath by breath to test if this was the mechanism of exercise limitation [24].
  • OBJECTIVE: The objective of this study was to determine the effect of body hair (scalp and facial) on air displacement plethysmography (BOD POD) estimates of percentage of body fat [25].
  • DESIGN: Forearm blood flow was studied using venous occlusion plethysmography in patients with chronic heart failure (n = 12) and matched controls (n = 13), after infusion of L-NMMA (a nitric oxide synthase inhibitor), glyceryl trinitrate (an endothelium independent vasodilator), and serotonin (an endothelium dependent vasodilator) [26].

Associations of Plethysmography with chemical compounds


Gene context of Plethysmography

  • METHODS: Forearm blood flow (FBF) responses (strain-gauge plethysmography) to intra-arterial infusion of a selective blocker of ETA receptors (BQ-123) and, on a separate occasion, to ET-1 were measured in 12 hypercholesterolemic patients and 12 normal control subjects [32].
  • Forearm blood flow (FBF) was measured by venous occlusion plethysmography and plasma levels of ET-1 were analyzed [33].
  • Ventilatory responses to acute hypoxia were measured by indirect plethysmography in unanesthetized, unrestrained wild-type mice and in mice in which the NEP gene was deleted (NEP -/-) [34].
  • Blood pressure measured by tail-cuff plethysmography was significantly elevated in the male 129/COX-2-/- mice (165.8 +/- 9.2 vs. 116 +/- 5.1 mmHg, P < 0.05), and to a much lesser extent in the female 129/COX-2-/- mice (127.4 +/- 3.3 vs. 102.4 +/- 3.3), whereas it was unchanged in the C57- or BALB/COX-2-/- mice regardless of gender [35].
  • Study variables were forearm blood flow (strain-gauge plethysmography), arterial and venous concentrations of t-PA mass concentrations, and calculated net release (forearm plasma flow x veno-arterial differences) [36].

Analytical, diagnostic and therapeutic context of Plethysmography


  1. Impaired reactivity of the peripheral vasculature to pressor agents in alcoholic cirrhosis. Ryan, J., Sudhir, K., Jennings, G., Esler, M., Dudley, F. Gastroenterology (1993) [Pubmed]
  2. Endothelium-dependent relaxation by acetylcholine is impaired in hypertriglyceridemic humans with normal levels of plasma LDL cholesterol. Lewis, T.V., Dart, A.M., Chin-Dusting, J.P. J. Am. Coll. Cardiol. (1999) [Pubmed]
  3. Hemodynamic and endocrine changes associated with captopril in diuretic-resistant hypertensive patients. Fujita, T., Ando, K., Noda, H., Sato, Y., Yamashita, N., Yamashita, K. Am. J. Med. (1982) [Pubmed]
  4. Evidence for altered vascular responses to exogenous endothelin-1 in patients with advanced cirrhosis with restoration of the normal vasoconstrictor response following successful liver transplantation. Vaughan, R.B., Angus, P.W., Chin-Dusting, J.P. Gut (2003) [Pubmed]
  5. Intravascular source of adenosine during forearm ischemia in humans: implications for reactive hyperemia. Costa, F., Sulur, P., Angel, M., Cavalcante, J., Haile, V., Christman, B., Biaggioni, I. Hypertension (1999) [Pubmed]
  6. Combined technetium radioisotope penile plethysmography and xenon washout: a technique for evaluating corpora cavernosal inflow and outflow during early tumescence. Schwartz, A.N., Graham, M.M. J. Nucl. Med. (1991) [Pubmed]
  7. Attenuation of isoproterenol-mediated vasodilatation in blacks. Lang, C.C., Stein, C.M., Brown, R.M., Deegan, R., Nelson, R., He, H.B., Wood, M., Wood, A.J. N. Engl. J. Med. (1995) [Pubmed]
  8. Improvement in endothelial function by angiotensin converting enzyme inhibition in insulin-dependent diabetes mellitus. O'Driscoll, G., Green, D., Rankin, J., Stanton, K., Taylor, R. J. Clin. Invest. (1997) [Pubmed]
  9. Hemodynamic and neurohumoral effects of various grades of selective adenosine transport inhibition in humans. Implications for its future role in cardioprotection. Rongen, G.A., Smits, P., Ver Donck, K., Willemsen, J.J., De Abreu, R.A., Van Belle, H., Thien, T. J. Clin. Invest. (1995) [Pubmed]
  10. Homologous upregulation of human arterial alpha-adrenergic responses by guanadrel. Hogikyan, R.V., Supiano, M.A. J. Clin. Invest. (1993) [Pubmed]
  11. Double-blind trial of CL115,347, a transdermally absorbed prostaglandin E2 analogue, in treatment of Raynaud's phenomenon. Belch, J.J., Madhok, R., Shaw, B., Leiberman, P., Sturrock, R.D., Forbes, C.D. Lancet (1985) [Pubmed]
  12. Effect of the angiotensin-converting enzyme inhibitor imidapril on reactive hyperemia in patients with essential hypertension: relationship between treatment periods and resistance artery endothelial function. Higashi, Y., Sasaki, S., Nakagawa, K., Matsuura, H., Kajiyama, G., Oshima, T. J. Am. Coll. Cardiol. (2001) [Pubmed]
  13. Effects of regional phentolamine on hypoxic vasodilatation in healthy humans. Weisbrod, C.J., Minson, C.T., Joyner, M.J., Halliwill, J.R. J. Physiol. (Lond.) (2001) [Pubmed]
  14. Long-term treatment with losartan versus atenolol improves insulin sensitivity in hypertension: ICARUS, a LIFE substudy. Olsen, M.H., Fossum, E., Høieggen, A., Wachtell, K., Hjerkinn, E., Nesbitt, S.D., Andersen, U.B., Phillips, R.A., Gaboury, C.L., Ibsen, H., Kjeldsen, S.E., Julius, S. J. Hypertens. (2005) [Pubmed]
  15. Subcutaneous vs intravenous heparin in the treatment of deep venous thrombosis--a randomized clinical trial. Pini, M., Pattachini, C., Quintavalla, R., Poli, T., Megha, A., Tagliaferri, A., Manotti, C., Dettori, A.G. Thromb. Haemost. (1990) [Pubmed]
  16. Variability of the breathing pattern in newborn rats: effects of ambient temperature in normoxia or hypoxia. Cameron, Y.L., Merazzi, D., Mortola, J.P. Pediatr. Res. (2000) [Pubmed]
  17. Endothelial vasodilator function is related to low-density lipoprotein particle size and low-density lipoprotein vitamin E content in type 1 diabetes. Skyrme-Jones, R.A., O'Brien, R.C., Luo, M., Meredith, I.T. J. Am. Coll. Cardiol. (2000) [Pubmed]
  18. Chronic inhibition of bradykinin B2-receptors enhances the slow vasopressor response to angiotensin II. Madeddu, P., Parpaglia, P.P., Demontis, M.P., Varoni, M.V., Fattaccio, M.C., Glorioso, N. Hypertension (1994) [Pubmed]
  19. The balance between vascular alpha- and beta-adrenoceptors is not changed in the elderly. Klein, C., Hiatt, W.R., Gerber, J.G., Nies, A.S. Clin. Pharmacol. Ther. (1987) [Pubmed]
  20. Systemic effects of three beta-blocker eyedrops: comparison in healthy volunteers of beta 1- and beta 2-adrenoreceptor inhibition. Le Jeunne, C., Munera, Y., Hugues, F.C. Clin. Pharmacol. Ther. (1990) [Pubmed]
  21. Forearm vascular alpha 1-adrenergic blockade by verapamil. Abernethy, D.R., Winterbottom, L.M. Clin. Pharmacol. Ther. (1990) [Pubmed]
  22. Contrasting effects of propranolol on sympathetic nerve activity and vascular resistance during orthostatic stress. Jacobsen, T.N., Converse, R.L., Victor, R.G. Circulation (1992) [Pubmed]
  23. Evaluation of regional haemodynamics and alterations of vascular wall of the lower limbs in hypertensive subjects. Pinto, A., Scaglione, R., Galati, D., Paterna, S., Parrinello, G., Arnone, S., Licata, G. Eur. Heart J. (1995) [Pubmed]
  24. Regional chest wall volumes during exercise in chronic obstructive pulmonary disease. Aliverti, A., Stevenson, N., Dellacà, R.L., Lo Mauro, A., Pedotti, A., Calverley, P.M. Thorax (2004) [Pubmed]
  25. Effect of scalp and facial hair on air displacement plethysmography estimates of percentage of body fat. Higgins, P.B., Fields, D.A., Hunter, G.R., Gower, B.A. Obes. Res. (2001) [Pubmed]
  26. Abnormal vascular responses in human chronic cardiac failure are both endothelium dependent and endothelium independent. Maguire, S.M., Nugent, A.G., McGurk, C., Johnston, G.D., Nicholls, D.P. Heart (1998) [Pubmed]
  27. Noninvasive assessment of portal-systemic shunting: evaluation of a method to investigate systemic availability of oral glyceryl trinitrate by digital plethysmography. Porchet, H., Bircher, J. Gastroenterology (1982) [Pubmed]
  28. Antioxidant vitamin C improves endothelial dysfunction in chronic smokers. Heitzer, T., Just, H., Münzel, T. Circulation (1996) [Pubmed]
  29. Diminished vascular response to inhibition of endothelium-derived nitric oxide and enhanced vasoconstriction to exogenously administered endothelin-1 in clinically healthy smokers. Kiowski, W., Linder, L., Stoschitzky, K., Pfisterer, M., Burckhardt, D., Burkart, F., Bühler, F.R. Circulation (1994) [Pubmed]
  30. Effects of selective and nonselective beta-adrenergic blockade on mechanisms of exercise conditioning. Wolfel, E.E., Hiatt, W.R., Brammell, H.L., Carry, M.R., Ringel, S.P., Travis, V., Horwitz, L.D. Circulation (1986) [Pubmed]
  31. Selective loss of microvascular endothelial function in human hypercholesterolemia. Gilligan, D.M., Guetta, V., Panza, J.A., García, C.E., Quyyumi, A.A., Cannon, R.O. Circulation (1994) [Pubmed]
  32. Increased activity of endogenous endothelin in patients with hypercholesterolemia. Cardillo, C., Kilcoyne, C.M., Cannon, R.O., Panza, J.A. J. Am. Coll. Cardiol. (2000) [Pubmed]
  33. Blunted vascular response to endothelin-a receptor blockade in cyclosporine-treated lung transplant recipients. Silverborn, M., Ambring, A., Nilsson, F., Friberg, P., Jeppsson, A. J. Heart Lung Transplant. (2005) [Pubmed]
  34. Targeted deletion of the neutral endopeptidase gene alters ventilatory responses to acute hypoxia in mice. Grasemann, H., Lu, B., Jiao, A., Boudreau, J., Gerard, N.P., De Sanctis, G.T. J. Appl. Physiol. (1999) [Pubmed]
  35. Influence of genetic background and gender on hypertension and renal failure in COX-2-deficient mice. Yang, T., Huang, Y.G., Ye, W., Hansen, P., Schnermann, J.B., Briggs, J.P. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  36. Reactive hyperemia and tissue-type plasminogen activator release in hypertensive men. Dell'Omo, G., De Negri, F., Carmassi, F., Ruocco, L., Mariani, M., Pedrinelli, R. Blood Coagul. Fibrinolysis (2003) [Pubmed]
  37. Randomized, double-blind, placebo-controlled study of supplemental vitamin E on attenuation of the development of nitrate tolerance. Watanabe, H., Kakihana, M., Ohtsuka, S., Sugishita, Y. Circulation (1997) [Pubmed]
  38. Nifedipine as a therapeutic modality for Raynaud's phenomenon. Winston, E.L., Pariser, K.M., Miller, K.B., Salem, D.N., Creager, M.A. Arthritis Rheum. (1983) [Pubmed]
  39. Improved endothelial function by the thromboxane A2 receptor antagonist S 18886 in patients with coronary artery disease treated with aspirin. Belhassen, L., Pelle, G., Dubois-Rande, J.L., Adnot, S. J. Am. Coll. Cardiol. (2003) [Pubmed]
  40. Opposing effects of angiotensin II on muscle and renal blood flow under euglycemic conditions. Fliser, D., Dikow, R., Demukaj, S., Ritz, E. J. Am. Soc. Nephrol. (2000) [Pubmed]
  41. Physiological hyperinsulinaemia increases intramuscular microvascular reactive hyperaemia and vasomotion in healthy volunteers. de Jongh, R.T., Clark, A.D., IJzerman, R.G., Serné, E.H., de Vries, G., Stehouwer, C.D. Diabetologia (2004) [Pubmed]
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