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Gene Review

FUT6  -  fucosyltransferase 6 (alpha (1,3)...

Homo sapiens

Synonyms: Alpha-(1,3)-fucosyltransferase 6, FCT3A, FLJ40754, FT1A, Fuc-TVI, ...
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High impact information on FUT6

  • Coding region sequence analysis and alpha(1,3)Fuc-T acceptor specificity comparisons with recombinant human Fuc-TV and Fuc-TVI showed that the cloned FUT gene is orthologous to the human FUT6 gene [1].
  • By contrast, somatic cell hybrid analyses revealed that LEC11B cells express FUT6 gene transcripts due to the loss of a trans-acting, negative regulatory factor [1].
  • This factor is predicted to be a cell type-specific regulator of FUT6 gene expression in mammals [1].
  • The blots showed that rearrangements had occurred in LEC11A and LEC11 genomic DNA, consistent with a cis mechanism of FUT6 gene activation in these mutants [1].
  • The human alpha(1,3)-fucosyltransferase genes FUT3, FUT5, and FUT6 form a cluster on chromosome 19p13 [2].

Biological context of FUT6

  • Missense and nonsense point mutations have been found to inactivate the cognate enzymes of FUT1, FUT3 and FUT6 [3].
  • FUT3 and FUT6 are closely linked on the short arm of chromosome 19 and encode the Lewis and plasma enzymes respectively [3].
  • Two polyadenylation sites were also shown for FUT6, with the alternatively spliced downstream signal in tissues expressing high levels of FUT6 [2].
  • These results demonstrate that the alpha(1,3)-fucosyltransferase activity in human plasma is encoded by the FUT6 gene and that the missense mutation within codon 247 of this gene is responsible for deficiency of this activity in these Indonesian families [4].
  • We report the disruption of sialyl Lewis x/a biosynthesis and inhibition of colon carcinoma cell proliferation by stable transfection of antisense sequences directed at the human Lewis alpha(1,3/1,4)fucosyltransferase gene, FUT3, and the plasma alpha(1,3)fucosyltransferase gene, FUT6 [5].

Anatomical context of FUT6

  • By contrast, two of the codon changes in the FUT6 alleles inactivate this gene when tested by expression in transfected COS-1 cells [4].

Other interactions of FUT6

  • Six human alpha-L-fucosyltransferase genes have been registered in the GDB as FUT1 to FUT6 according to the chronology of their description [3].
  • FUT3 and FUT6 were expressed at high levels, while FUT5 expression was lower and restricted to fewer cell types [2].
  • F(ST) between the Asians and the others measured at FUT2 was higher than at FUT6 [6].

Analytical, diagnostic and therapeutic context of FUT6


  1. The gain-of-function Chinese hamster ovary mutant LEC11B expresses one of two Chinese hamster FUT6 genes due to the loss of a negative regulatory factor. Zhang, A., Potvin, B., Zaiman, A., Chen, W., Kumar, R., Phillips, L., Stanley, P. J. Biol. Chem. (1999) [Pubmed]
  2. Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. Cameron, H.S., Szczepaniak, D., Weston, B.W. J. Biol. Chem. (1995) [Pubmed]
  3. Molecular genetics of alpha-L-fucosyltransferase genes (H, Se, Le, FUT4, FUT5 and FUT6). Mollicone, R., Candelier, J.J., Reguigne, I., Couillin, P., Fletcher, A., Oriol, R. Transfusion clinique et biologique : journal de la Société française de transfusion sanguine. (1994) [Pubmed]
  4. Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6). Mollicone, R., Reguigne, I., Fletcher, A., Aziz, A., Rustam, M., Weston, B.W., Kelly, R.J., Lowe, J.B., Oriol, R. J. Biol. Chem. (1994) [Pubmed]
  5. Transfection of alpha(1,3)fucosyltransferase antisense sequences impairs the proliferative and tumorigenic ability of human colon carcinoma cells. Hiller, K.M., Mayben, J.P., Bendt, K.M., Manousos, G.A., Senger, K., Cameron, H.S., Weston, B.W. Mol. Carcinog. (2000) [Pubmed]
  6. Contrasting patterns of polymorphisms at the ABO-secretor gene (FUT2) and plasma alpha(1,3)fucosyltransferase gene (FUT6) in human populations. Koda, Y., Tachida, H., Pang, H., Liu, Y., Soejima, M., Ghaderi, A.A., Takenaka, O., Kimura, H. Genetics (2001) [Pubmed]
  7. FUT4 and FUT9 genes are expressed early in human embryogenesis. Cailleau-Thomas, A., Coullin, P., Candelier, J.J., Balanzino, L., Mennesson, B., Oriol, R., Mollicone, R. Glycobiology (2000) [Pubmed]
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