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Gene Review

FUT1  -  fucosyltransferase 1 (galactoside 2-alpha...

Homo sapiens

Synonyms: Alpha(1,2)FT 1, Blood group H alpha 2-fucosyltransferase, Fucosyltransferase 1, GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1, Galactoside 2-alpha-L-fucosyltransferase 1, ...
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Disease relevance of FUT1

  • The results of RT-PCR using specific primers for each starting exon suggested that two transcription initiation sites (exon 1A and exon 2A) of the FUT1 were identified in gastric cancer cells and in ovarian cancer cells [1].
  • Two alpha1,2-fucosyltransferases, expressed in colorectal carcinomas, have been characterized (FUT1 and FUT2 in humans, FTA and FTB in rats) [2].
  • Direct sequencing of the two ORFs in swine being either susceptible or resistant to adhesion and colonization by F18 fimbriated Escherichia coli (ECF18) revealed two polymorphisms at bp 307 (M307) and bp 857 (M857) of the FUT1 ORF [3].
  • In the present study, we have investigated these transcription start sites of FUT1 in undifferentiated leukemic cells (K562) that have erythroid characteristics, in erythroleukemia cells (HEL), and in bone marrow cells [4].
  • The heat sensitivity was observed to increase in the FUT1 gene transfected cells and the effect of hyperthermia at 44 degrees C on these cells was demonstrated to be significant (P<0.001) to the wild type cells even though no remarkable difference in the expression of the heat shock protein, Hsp70 was found in these cells [5].

Psychiatry related information on FUT1

  • With this system, we found that de novo expression of the fucosyltransferase in mouse recipient cells was associated with the transfer and stable genomic integration of characteristic human DNA restriction fragments [6].

High impact information on FUT1


Chemical compound and disease context of FUT1


Biological context of FUT1

  • One cosmid has been isolated that contains two distinct segments that cross-hybridize with FUT1 [16].
  • STUDY DESIGN AND METHODS: The FUT1 gene of an Austrian proband with the Bombay phenotype was characterized by nucleotide sequencing of the full-length coding sequence [17].
  • CONCLUSION: The missense mutation S262K in the FUT1 gene caused the loss of H transferase activity [17].
  • Families segregating for deficiency of the H alpha-2-L-fucosyltransferase, FUT1, have been investigated for linkage between FUT1 and other markers on chromosome 19 [18].
  • Comparative DNA sequence analysis showed the Généthon microsatellite D19S596 lies 2.2 kb downstream of the coding region of FUT1, indicating that the cluster comprising the closely linked FUT1 and FUT2 genes is located 4 cM distal to D19S412 (lod score 13.7) and 9 cM proximal to D19S571 (lod score 11.7) [19].

Anatomical context of FUT1

  • Although FUT1 is expressed in the COS cell mRNA, it has not been possible to demonstrate alpha1,2-fucosyltransferase activity in cell extracts but the presence of Le(y) and blood-group A antigenic determinants on the cell surface imply the formation of H-precursor structures at some stage [20].
  • The alpha-2-fucosyltransferases: FUT1 (H) of red cells and vascular endothelium and FUT2 (Se) of exocrine secretions [21].
  • Fucosyltransferase activities in human pancreatic tissue: comparative study between cancer tissues and established tumoral cell lines [22].
  • A myeloid enzyme is present in 5 to 10 week old human embryos and is later progressively replaced by different patterns of adult fucosyltransferase enzymes in all tissues, except in leukocytes and brain which continue to express a FUT4 like enzyme in the adult.(ABSTRACT TRUNCATED AT 250 WORDS)[23]
  • The Fucalpha(1-->2)Galbeta epitope is absent from the uterine epithelia of FUT2 null mice and from the epithelia of the epididymis of FUT1 null mice [24].

Associations of FUT1 with chemical compounds

  • Two nucleotide changes, G785A and C786A, in codon 262 of the FUT1 gene resulted in the replacement of serine by lysine [17].
  • FUT1 and FUT2 encode the alpha(1,2)fucosyltransferases H and Se respectively [23].
  • Sequence analysis revealed that these genes, called FTA, FTB and FTC, were homologous to human FUT1, FUT2 and Sec1, respectively [25].
  • The degree of fucosylation of alpha1-acid glycoprotein was correlated with alpha3-fucosyltransferase activity (Rs = 0.82) [26].
  • This became evident from the 4-fold activity of alpha 1,2-L-FT toward bovine IgG glycopeptide after approximately 5% removal of alpha 1,6-linked Fuo [27].

Physical interactions of FUT1


Regulatory relationships of FUT1


Other interactions of FUT1


Analytical, diagnostic and therapeutic context of FUT1


  1. Structure and expression of H-type GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase gene (FUT1). Two transcription start sites and alternative splicing generate several forms of FUT1 mRNA. Koda, Y., Soejima, M., Kimura, H. J. Biol. Chem. (1997) [Pubmed]
  2. Increased tumorigenicity of rat colon carcinoma cells after alpha1,2-fucosyltransferase FTA anti-sense cDNA transfection. Hallouin, F., Goupille, C., Bureau, V., Meflah, K., Le Pendu, J. Int. J. Cancer (1999) [Pubmed]
  3. Two alpha(1,2) fucosyltransferase genes on porcine chromosome 6q11 are closely linked to the blood group inhibitor (S) and Escherichia coli F18 receptor (ECF18R) loci. Meijerink, E., Fries, R., Vögeli, P., Masabanda, J., Wigger, G., Stricker, C., Neuenschwander, S., Bertschinger, H.U., Stranzinger, G. Mamm. Genome (1997) [Pubmed]
  4. Changing transcription start sites in H-type alpha(1,2)fucosyltransferase gene (FUT1) during differentiation of the human erythroid lineage. Koda, Y., Soejima, M., Kimura, H. Eur. J. Biochem. (1998) [Pubmed]
  5. Increased thermosensitivity of mouse colorectal carcinoma cells transfected with human FUT1 gene. Okamura, A., Yazawa, S., Morinaga, N., Asao, T., Kuwano, H. Cancer Lett. (2002) [Pubmed]
  6. A cloned human DNA restriction fragment determines expression of a GDP-L-fucose: beta-D-galactoside 2-alpha-L-fucosyltransferase in transfected cells. Evidence for isolation and transfer of the human H blood group locus. Rajan, V.P., Larsen, R.D., Ajmera, S., Ernst, L.K., Lowe, J.B. J. Biol. Chem. (1989) [Pubmed]
  7. The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter. Lühn, K., Wild, M.K., Eckhardt, M., Gerardy-Schahn, R., Vestweber, D. Nat. Genet. (2001) [Pubmed]
  8. Expression cloning of a functional glycoprotein ligand for P-selectin. Sako, D., Chang, X.J., Barone, K.M., Vachino, G., White, H.M., Shaw, G., Veldman, G.M., Bean, K.M., Ahern, T.J., Furie, B. Cell (1993) [Pubmed]
  9. ELAM-1--dependent cell adhesion to vascular endothelium determined by a transfected human fucosyltransferase cDNA. Lowe, J.B., Stoolman, L.M., Nair, R.P., Larsen, R.D., Berhend, T.L., Marks, R.M. Cell (1990) [Pubmed]
  10. Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Fuhlbrigge, R.C., Kieffer, J.D., Armerding, D., Kupper, T.S. Nature (1997) [Pubmed]
  11. Expression of alpha-1,3-fucosyltransferase type IV and VII genes is related to poor prognosis in lung cancer. Ogawa, J., Inoue, H., Koide, S. Cancer Res. (1996) [Pubmed]
  12. Restoration of alpha(1,2) fucosyltransferase activity decreases adhesive and metastatic properties of human pancreatic cancer cells. Aubert, M., Panicot, L., Crotte, C., Gibier, P., Lombardo, D., Sadoulet, M.O., Mas, E. Cancer Res. (2000) [Pubmed]
  13. Ito cells are liver-resident antigen-presenting cells for activating T cell responses. Winau, F., Hegasy, G., Weiskirchen, R., Weber, S., Cassan, C., Sieling, P.A., Modlin, R.L., Liblau, R.S., Gressner, A.M., Kaufmann, S.H. Immunity (2007) [Pubmed]
  14. Guanosine diphosphate-L-fucose plasma: N-acetylglucosaminide fucosyltransferase as in index of bone marrow hyperplasia after chemotherapy. Khilanani, P., Chou, T.H., Kessel, D. Cancer Res. (1978) [Pubmed]
  15. Pirfenidone effectively reverses experimental liver fibrosis. García, L., Hernández, I., Sandoval, A., Salazar, A., Garcia, J., Vera, J., Grijalva, G., Muriel, P., Margolin, S., Armendariz-Borunda, J. J. Hepatol. (2002) [Pubmed]
  16. Molecular cloning of a human genomic region containing the H blood group alpha(1,2)fucosyltransferase gene and two H locus-related DNA restriction fragments. Isolation of a candidate for the human Secretor blood group locus. Rouquier, S., Lowe, J.B., Kelly, R.J., Fertitta, A.L., Lennon, G.G., Giorgi, D. J. Biol. Chem. (1995) [Pubmed]
  17. A new h allele detected in Europe has a missense mutationin alpha(1,2)-fucosyltransferase motif II. Wagner, T., Vadon, M., Staudacher, E., Schmarda, A., Gassner, C., Helmberg, W., Lanzer, G., Flegel, W.A., Wagner, F.F. Transfusion (2001) [Pubmed]
  18. The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9. Ball, S.P., Tongue, N., Gibaud, A., Le Pendu, J., Mollicone, R., Gérard, G., Oriol, R. Ann. Hum. Genet. (1991) [Pubmed]
  19. Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19. Reguigne-Arnould, I., Couillin, P., Mollicone, R., Fauré, S., Fletcher, A., Kelly, R.J., Lowe, J.B., Oriol, R. Cytogenet. Cell Genet. (1995) [Pubmed]
  20. Expression of human alpha-l-fucosyltransferase gene homologs in monkey kidney COS cells and modification of potential fucosyltransferase acceptor substrates by an endogenous glycosidase. Clarke, J.L., Watkins, W.M. Glycobiology (1999) [Pubmed]
  21. Molecular genetics of H, Se, Lewis and other fucosyltransferase genes. Mollicone, R., Cailleau, A., Oriol, R. Transfusion clinique et biologique : journal de la Société française de transfusion sanguine. (1995) [Pubmed]
  22. Fucosyltransferase activities in human pancreatic tissue: comparative study between cancer tissues and established tumoral cell lines. Mas, E., Pasqualini, E., Caillol, N., El Battari, A., Crotte, C., Lombardo, D., Sadoulet, M.O. Glycobiology (1998) [Pubmed]
  23. Molecular genetics of alpha-L-fucosyltransferase genes (H, Se, Le, FUT4, FUT5 and FUT6). Mollicone, R., Candelier, J.J., Reguigne, I., Couillin, P., Fletcher, A., Oriol, R. Transfusion clinique et biologique : journal de la Société française de transfusion sanguine. (1994) [Pubmed]
  24. Deficiency of reproductive tract alpha(1,2)fucosylated glycans and normal fertility in mice with targeted deletions of the FUT1 or FUT2 alpha(1,2)fucosyltransferase locus. Domino, S.E., Zhang, L., Gillespie, P.J., Saunders, T.L., Lowe, J.B. Mol. Cell. Biol. (2001) [Pubmed]
  25. Comparison of the three rat GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferases FTA, FTB and FTC. Bureau, V., Marionneau, S., Cailleau-Thomas, A., Le Moullac-Vaidye, B., Liehr, T., Le Pendu, J. Eur. J. Biochem. (2001) [Pubmed]
  26. A missense mutation in the FUT6 gene results in total absence of alpha3-fucosylation of human alpha1-acid glycoprotein. Brinkman-Van der Linden, E.C., Mollicone, R., Oriol, R., Larson, G., Van den Eijnden, D.H., Van Dijk, W. J. Biol. Chem. (1996) [Pubmed]
  27. Characterization of the specificities of human blood group H gene-specified alpha 1,2-L-fucosyltransferase toward sulfated/sialylated/fucosylated acceptors: evidence for an inverse relationship between alpha 1,2-L-fucosylation of Gal and alpha 1,6-L-fucosylation of asparagine-linked GlcNAc. Chandrasekaran, E.V., Jain, R.K., Larsen, R.D., Wlasichuk, K., Matta, K.L. Biochemistry (1996) [Pubmed]
  28. CEACAM1, an adhesion molecule of human granulocytes, is fucosylated by fucosyltransferase IX and interacts with DC-SIGN of dendritic cells via Lewis x residues. Bogoevska, V., Horst, A., Klampe, B., Lucka, L., Wagener, C., Nollau, P. Glycobiology (2006) [Pubmed]
  29. Molecular basis of leukocyte rolling on PSGL-1. Predominant role of core-2 O-glycans and of tyrosine sulfate residue 51. Bernimoulin, M.P., Zeng, X.L., Abbal, C., Giraud, S., Martinez, M., Michielin, O., Schapira, M., Spertini, O. J. Biol. Chem. (2003) [Pubmed]
  30. The fucosyltransferase FucT-VII regulates E-selectin ligand synthesis in human T cells. Knibbs, R.N., Craig, R.A., Natsuka, S., Chang, A., Cameron, M., Lowe, J.B., Stoolman, L.M. J. Cell Biol. (1996) [Pubmed]
  31. Advances in molecular genetics of alpha-2- and alpha-3/4-fucosyltransferases. Costache, M., Cailleau, A., Fernandez-Mateos, P., Oriol, R., Mollicone, R. Transfusion clinique et biologique : journal de la Société française de transfusion sanguine. (1997) [Pubmed]
  32. Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system. Koda, Y., Soejima, M., Johnson, P.H., Smart, E., Kimura, H. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  33. Molecular cloning, chromosomal assignment and tissue-specific expression of a murine alpha(1,2)fucosyltransferase expressed in thymic and epididymal epithelial cells. Domino, S.E., Hiraiwa, N., Lowe, J.B. Biochem. J. (1997) [Pubmed]
  34. Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen. Larsen, R.D., Ernst, L.K., Nair, R.P., Lowe, J.B. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
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