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Gene Review

rum1  -  CDK inhibitor Rum1

Schizosaccharomyces pombe 972h-

 
 
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High impact information on rum1

  • Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene [1].
  • The high ploidy phenotype in the pop1 mutant is dependent on the presence of the rum1+ gene, whereas the accumulation of Cdc18 is independent of Rum1 [2].
  • One involves the product of the rum1 gene and prevents cells from entering mitosis from the pre-Start G1 interval [3].
  • Yeast genetics have implicated three important genes involved in DNA ploidy changes: cdc2, cyclin b, and a specific inhibitor of the p34(cdc2)/cyclin B kinase, rum1 [4].
  • This model was examined by induction of overreplication of the genome by overexpression of rum1p or cdc18p [5].
 

Biological context of rum1

 

Regulatory relationships of rum1

  • Cdc2/puc1 function may be important to down-regulate the rum1 Cdk inhibitor at the end of G1 [8].
 

Other interactions of rum1

  • We propose that rum1p acts as an adaptor targeting cdc13p for degradation by the cyclosome [9].
  • Cyclin B proteolysis and the cyclin-dependent kinase inhibitor rum1p are required for pheromone-induced G1 arrest in fission yeast [9].
  • Third, in rum1 delta wee1-50 where the normal long G1 in wee1 is much reduced, there is probably no size control either in G1 or in G2 causing a continuous shortening of division length from cycle to cycle [10].

References

  1. Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene. Moreno, S., Nurse, P. Nature (1994) [Pubmed]
  2. Fission yeast WD-repeat protein pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18. Kominami, K., Toda, T. Genes Dev. (1997) [Pubmed]
  3. Checkpoints in the cell cycle of fission yeast. D'Urso, G., Nurse, P. Curr. Opin. Genet. Dev. (1995) [Pubmed]
  4. A brief staurosporine treatment of mitotic cells triggers premature exit from mitosis and polyploid cell formation. Hall, L.L., Th'ng, J.P., Guo, X.W., Teplitz, R.L., Bradbury, E.M. Cancer Res. (1996) [Pubmed]
  5. Spindle pole body duplication in fission yeast occurs at the G1/S boundary but maturation is blocked until exit from S by an event downstream of cdc10+. Uzawa, S., Li, F., Jin, Y., McDonald, K.L., Braunfeld, M.B., Agard, D.A., Cande, W.Z. Mol. Biol. Cell (2004) [Pubmed]
  6. Regulated mRNA stability of the Cdk inhibitor Rum1 links nutrient status to cell cycle progression. Daga, R.R., Bolaños, P., Moreno, S. Curr. Biol. (2003) [Pubmed]
  7. Interaction of cdc2 and rum1 regulates Start and S-phase in fission yeast. Labib, K., Moreno, S., Nurse, P. J. Cell. Sci. (1995) [Pubmed]
  8. The puc1 cyclin regulates the G1 phase of the fission yeast cell cycle in response to cell size. Martín-Castellanos, C., Blanco, M.A., de Prada, J.M., Moreno, S. Mol. Biol. Cell (2000) [Pubmed]
  9. Cyclin B proteolysis and the cyclin-dependent kinase inhibitor rum1p are required for pheromone-induced G1 arrest in fission yeast. Stern, B., Nurse, P. Mol. Biol. Cell (1998) [Pubmed]
  10. The size control of fission yeast revisited. Sveiczer, A., Novak, B., Mitchison, J.M. J. Cell. Sci. (1996) [Pubmed]
 
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