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Gene Review

tdh1  -  glyceraldehyde-3-phosphate dehydrogenase Tdh1

Schizosaccharomyces pombe 972h-

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High impact information on gpd1

  • (iii) delta gpd1 mutants, however, failed to do so even in a high-osmolarity medium, and thus exhibited an Osms phenotype [1].
  • The nucleotide sequences, determined for these genes (named gpd1+ and gpd2+, respectively), revealed that S. pombe has two distinct GPD isozymes [1].
  • Accordingly, a delta atf1 mutant is known to exhibit osmosensitivity for growth, since one of the targets of Atf1 is the gpd1+ gene, which is responsible for the osmoadaptive glycerol production mediated by the Sty1 MAPK cascade [2].


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