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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

tdh1  -  glyceraldehyde-3-phosphate dehydrogenase Tdh1

Schizosaccharomyces pombe 972h-

 
 
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High impact information on gpd1

  • (iii) delta gpd1 mutants, however, failed to do so even in a high-osmolarity medium, and thus exhibited an Osms phenotype [1].
  • The nucleotide sequences, determined for these genes (named gpd1+ and gpd2+, respectively), revealed that S. pombe has two distinct GPD isozymes [1].
  • Accordingly, a delta atf1 mutant is known to exhibit osmosensitivity for growth, since one of the targets of Atf1 is the gpd1+ gene, which is responsible for the osmoadaptive glycerol production mediated by the Sty1 MAPK cascade [2].

References

  1. Osmoregulation of fission yeast: cloning of two distinct genes encoding glycerol-3-phosphate dehydrogenase, one of which is responsible for osmotolerance for growth. Ohmiya, R., Yamada, H., Nakashima, K., Aiba, H., Mizuno, T. Mol. Microbiol. (1995) [Pubmed]
  2. Isolation of multicopy suppressors of the calcium sensitivity of a mutant lacking the bZIP transcription factor Atf1 in fission yeast. Ohmiya, R., Kato, C., Yamada, H., Aiba, H., Mizuno, T. Mol. Gen. Genet. (1999) [Pubmed]
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