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Gene Review

Gapdh  -  glyceraldehyde-3-phosphate dehydrogenase

Rattus norvegicus

Synonyms: 38 kDa BFA-dependent ADP-ribosylation substrate, BARS-38, GAPDH, Gapd, Glyceraldehyde-3-phosphate dehydrogenase, ...
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Disease relevance of Gapdh

  • The expressions of glyseraldehyde-3-phosphate dehydrogenase (GAPDH), beta-actin, cyclophilin, and RPL13A were examined in order to validate the appropriate housekeeping genes for a long duration after inducing cerebral ischemia [1].

High impact information on Gapdh


Biological context of Gapdh


Anatomical context of Gapdh


Associations of Gapdh with chemical compounds


Analytical, diagnostic and therapeutic context of Gapdh

  • MALDI-TOF mass fingerprint analysis of tryptic peptides independently confirmed actin and glyceraldehyde-3-phosphate dehydrogenase S-thiolation during reperfusion [3].
  • Total RNA specific for the BDV nucleoprotein (BDV-N) and the cellular genes glyceraldehyde-3-phosphate dehydrogenase (GAPDH), succinate-ubiquinone reductase (SDHA) and hypoxanthine phosphoribosyl-transferase-1 (HPRT) was measured by real-time RT-PCR and compared to BDV-infected control samples [14].


  1. The quantification of ADAMTS expression in an animal model of cerebral ischemia using real-time PCR. Tian, Y.F., Zhang, P.B., Xiao, X.L., Zhang, J.S., Zhao, J.J., Kang, Q.Y., Chen, X.L., Qiu, F., Liu, Y. Acta anaesthesiologica Scandinavica (2007) [Pubmed]
  2. Homogeneous distribution of phosphofructokinase in the rat liver acinus: a quantitative histochemical study. Frederiks, W.M., Marx, F., van Noorden, C.J. Hepatology (1991) [Pubmed]
  3. Detection, quantitation, purification, and identification of cardiac proteins S-thiolated during ischemia and reperfusion. Eaton, P., Byers, H.L., Leeds, N., Ward, M.A., Shattock, M.J. J. Biol. Chem. (2002) [Pubmed]
  4. Epidermal growth factor or serum stimulation of rat fibroblasts induces an elevation in mRNA levels for lactate dehydrogenase and other glycolytic enzymes. Matrisian, L.M., Rautmann, G., Magun, B.E., Breathnach, R. Nucleic Acids Res. (1985) [Pubmed]
  5. Protective effect of D609 against amyloid-beta1-42-induced oxidative modification of neuronal proteins: redox proteomics study. Sultana, R., Newman, S.F., Abdul, H.M., Cai, J., Pierce, W.M., Klein, J.B., Merchant, M., Butterfield, D.A. J. Neurosci. Res. (2006) [Pubmed]
  6. Effects of prototypical drug-metabolizing enzyme inducers on mRNA expression of housekeeping genes in primary cultures of human and rat hepatocytes. Nishimura, M., Koeda, A., Suzuki, E., Shimizu, T., Kawano, Y., Nakayama, M., Satoh, T., Narimatsu, S., Naito, S. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  7. Effects of isoflurane, pentobarbital, and urethane on apoptosis and apoptotic signal transduction in rat kidney. Aravindan, N., Cata, J.P., Hoffman, L., Dougherty, P.M., Riedel, B.J., Price, K.J., Shaw, A.D. Acta anaesthesiologica Scandinavica. (2006) [Pubmed]
  8. Ibogaine affects brain energy metabolism. Paskulin, R., Jamnik, P., Zivin, M., Raspor, P., Strukelj, B. Eur. J. Pharmacol. (2006) [Pubmed]
  9. Influence of oral administration of ornidazole on capacitation and the activity of some glycolytic enzymes of rat spermatozoa. Oberländer, G., Yeung, C.H., Cooper, T.G. J. Reprod. Fertil. (1996) [Pubmed]
  10. The effect of glutamine on prevention of glucocorticoid-induced skeletal muscle atrophy is associated with myostatin suppression. Salehian, B., Mahabadi, V., Bilas, J., Taylor, W.E., Ma, K. Metab. Clin. Exp. (2006) [Pubmed]
  11. Alcohol alters skeletal muscle heat shock protein gene expression in rats: these effects are moderated by sex, raised endogenous acetaldehyde, and starvation. Nakahara, T., Hunter, R., Hirano, M., Uchimura, H., McArdle, A., Broome, C.S., Koll, M., Martin, C.R., Preedy, V.R. Metab. Clin. Exp. (2006) [Pubmed]
  12. Effects of 6-chloro-6-deoxysugars on glucose oxidation in rat spermatozoa. Ford, W.C., Harrison, A., Waites, G.M. J. Reprod. Fertil. (1981) [Pubmed]
  13. Regulation of glycolytic enzyme RNA transcriptional rates by oxygen availability in skeletal muscle cells. Webster, K.A. Mol. Cell. Biochem. (1987) [Pubmed]
  14. Preservation of RNA and destruction of infectivity in microdissected brain tissues of Lewis rats infected with the Borna disease virus. Porombka, D., Herzog, S., Baumgärtner, W., Herden, C. J. Virol. Methods (2006) [Pubmed]
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