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Gene Review

TDH1  -  glyceraldehyde-3-phosphate dehydrogenase...

Saccharomyces cerevisiae S288c

Synonyms: GAPDH 1, GPD1, Glyceraldehyde-3-phosphate dehydrogenase 1, J1154, SSS2, ...
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Disease relevance of TDH1


Psychiatry related information on TDH1

  • Brownian dynamics simulations of yeast and muscle aldolase and GAPDH with yeast and muscle actin compared the relative association free energy [6].

High impact information on TDH1


Chemical compound and disease context of TDH1

  • In a previous study of quinone toxicity, this quinone, whose actions have been exclusively attributed to reactive oxygen species (ROS) generation, caused a reduction in the glycolytic activity of GAPDH under aerobic and anaerobic conditions, indicating indirect and possible direct actions on this enzyme [12].

Biological context of TDH1


Anatomical context of TDH1


Associations of TDH1 with chemical compounds


Physical interactions of TDH1


Regulatory relationships of TDH1


Other interactions of TDH1


Analytical, diagnostic and therapeutic context of TDH1


  1. Isolation and properties of the glycolytic enzymes from Zymomonas mobilis. The five enzymes from glyceraldehyde-3-phosphate dehydrogenase through to pyruvate kinase. Pawluk, A., Scopes, R.K., Griffiths-Smith, K. Biochem. J. (1986) [Pubmed]
  2. Cloning and sequence analysis of a glyceraldehyde-3-phosphate dehydrogenase gene from Ganoderma lucidum. Fei, X., Zhao, M.W., Li, Y.X. J. Microbiol. (2006) [Pubmed]
  3. Evaluation of the usefulness of anti-glyceraldehyde-3-phosphate dehydrogenase antibodies as a treatment for invasive candidiasis in a murine model. Gil, M.L., Dagan, S., Eren, R., Gozalbo, D. Antonie Van Leeuwenhoek (2006) [Pubmed]
  4. Isolation and characterization of a gene coding for glyceraldehyde-3-phosphate dehydrogenase from Saccharomyces cerevisiae. Holland, M.J., Holland, J.P. J. Biol. Chem. (1979) [Pubmed]
  5. The binding of nicotinamide-adenine dimucleotide to glyceraldehyde 3-phosphate dehydrogenase from Bacillus stearothermophilus. Allen, G., Harris, J.I. Biochem. J. (1975) [Pubmed]
  6. Glycolytic enzyme interactions with yeast and skeletal muscle F-actin. Waingeh, V.F., Gustafson, C.D., Kozliak, E.I., Lowe, S.L., Knull, H.R., Thomasson, K.A. Biophys. J. (2006) [Pubmed]
  7. Synthesis and processing of the plant protein thaumatin in yeast. Edens, L., Bom, I., Ledeboer, A.M., Maat, J., Toonen, M.Y., Visser, C., Verrips, C.T. Cell (1984) [Pubmed]
  8. The yeast SSS1 gene is essential for secretory protein translocation and encodes a conserved protein of the endoplasmic reticulum. Esnault, Y., Blondel, M.O., Deshaies, R.J., Scheckman, R., Képès, F. EMBO J. (1993) [Pubmed]
  9. Monitoring of intracellular calcium in Saccharomyces cerevisiae with an apoaequorin cDNA expression system. Nakajima-Shimada, J., Iida, H., Tsuji, F.I., Anraku, Y. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  10. Differential protein S-thiolation of glyceraldehyde-3-phosphate dehydrogenase isoenzymes influences sensitivity to oxidative stress. Grant, C.M., Quinn, K.A., Dawes, I.W. Mol. Cell. Biol. (1999) [Pubmed]
  11. The GCR1 gene encodes a positive transcriptional regulator of the enolase and glyceraldehyde-3-phosphate dehydrogenase gene families in Saccharomyces cerevisiae. Holland, M.J., Yokoi, T., Holland, J.P., Myambo, K., Innis, M.A. Mol. Cell. Biol. (1987) [Pubmed]
  12. The interactions of 9,10-phenanthrenequinone with glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a potential site for toxic actions. Rodriguez, C.E., Fukuto, J.M., Taguchi, K., Froines, J., Cho, A.K. Chem. Biol. Interact. (2005) [Pubmed]
  13. Isolation and characterization of yeast strains carrying mutations in the glyceraldehyde-3-phosphate dehydrogenase genes. McAlister, L., Holland, M.J. J. Biol. Chem. (1985) [Pubmed]
  14. Differential expression of the three yeast glyceraldehyde-3-phosphate dehydrogenase genes. McAlister, L., Holland, M.J. J. Biol. Chem. (1985) [Pubmed]
  15. The glyceraldehyde-3-phosphate dehydrogenase polypeptides encoded by the Saccharomyces cerevisiae TDH1, TDH2 and TDH3 genes are also cell wall proteins. Delgado, M.L., O'Connor, J.E., Azorín, I., Renau-Piqueras, J., Gil, M.L., Gozalbo, D. Microbiology (Reading, Engl.) (2001) [Pubmed]
  16. Interaction of the GTS1 gene product with glyceraldehyde- 3-phosphate dehydrogenase 1 required for the maintenance of the metabolic oscillations of the yeast Saccharomyces cerevisiae. Liu, W., Wang, J., Mitsui, K., Shen, H., Tsurugi, K. Eur. J. Biochem. (2002) [Pubmed]
  17. HOCl-mediated cell death and metabolic dysfunction in the yeast Saccharomyces cerevisiae. King, D.A., Hannum, D.M., Qi, J.S., Hurst, J.K. Arch. Biochem. Biophys. (2004) [Pubmed]
  18. 5'-secondary structure formation, in contrast to a short string of non-preferred codons, inhibits the translation of the pyruvate kinase mRNA in yeast. Bettany, A.J., Moore, P.A., Cafferkey, R., Bell, L.D., Goodey, A.R., Carter, B.L., Brown, A.J. Yeast (1989) [Pubmed]
  19. The transport of proteins into yeast mitochondria. Kinetics and pools. Ades, I.Z., Butow, R.A. J. Biol. Chem. (1980) [Pubmed]
  20. Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae. Cabiscol, E., Piulats, E., Echave, P., Herrero, E., Ros, J. J. Biol. Chem. (2000) [Pubmed]
  21. Regulation of protein S-thiolation by glutaredoxin 5 in the yeast Saccharomyces cerevisiae. Shenton, D., Perrone, G., Quinn, K.A., Dawes, I.W., Grant, C.M. J. Biol. Chem. (2002) [Pubmed]
  22. Identification of the first fungal NADP-GAPDH from Kluyveromyces lactis. Verho, R., Richard, P., Jonson, P.H., Sundqvist, L., Londesborough, J., Penttilä, M. Biochemistry (2002) [Pubmed]
  23. Immobilized glyceraldehyde-3-phosphate dehydrogenase forms a complex with phosphoglycerate kinase. Ashmarina, L.I., Muronetz, V.I., Nagradova, N.K. Biochem. Int. (1984) [Pubmed]
  24. The glyceraldehyde-3-phosphate dehydrogenase binds in vitro to the SH3 domain of Saccharomyces cerevisiae Cdc25p. Buu, A., Garreau, H., Jacquet, M. C. R. Acad. Sci. III, Sci. Vie (1995) [Pubmed]
  25. Effects of xylulokinase activity on ethanol production from D-xylulose by recombinant Saccharomyces cerevisiae. Lee, T.H., Kim, M.D., Park, Y.C., Bae, S.M., Ryu, Y.W., Seo, J.H. J. Appl. Microbiol. (2003) [Pubmed]
  26. Factors affecting homologous overexpression of the Saccharomyces cerevisiae lanosterol 14 alpha-demethylase gene. Weber, J.M., Ponti, C.G., Käppeli, O., Reiser, J. Yeast (1992) [Pubmed]
  27. Optimal growth and ethanol production from xylose by recombinant Saccharomyces cerevisiae require moderate D-xylulokinase activity. Jin, Y.S., Ni, H., Laplaza, J.M., Jeffries, T.W. Appl. Environ. Microbiol. (2003) [Pubmed]
  28. Srb7p is essential for the activation of a subset of genes. Gromöller, A., Lehming, N. FEBS Lett. (2000) [Pubmed]
  29. Protein S-thiolation targets glycolysis and protein synthesis in response to oxidative stress in the yeast Saccharomyces cerevisiae. Shenton, D., Grant, C.M. Biochem. J. (2003) [Pubmed]
  30. Characterization of purified poly(adenylic acid)-containing messenger ribonucleic acid from Saccharomyces cerevisiae. Holland, M.J., Hager, G.L., Rutter, W.J. Biochemistry (1977) [Pubmed]
  31. Candida albicans TDH3 gene promotes secretion of internal invertase when expressed in Saccharomyces cerevisiae as a glyceraldehyde-3-phosphate dehydrogenase-invertase fusion protein. Delgado, M.L., Gil, M.L., Gozalbo, D. Yeast (2003) [Pubmed]
  32. A protein homologous to glyceraldehyde-3-phosphate dehydrogenase is induced in the cell wall of a flocculent Kluyveromyces marxianus. Fernandes, P.A., Keen, J.N., Findlay, J.B., Moradas-Ferreira, P. Biochim. Biophys. Acta (1992) [Pubmed]
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