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Gene Review

gpd-3  -  Protein GPD-3

Caenorhabditis elegans

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Disease relevance of gpd-3

  • We found that not only is the daf-2(e1370)-enhanced anoxia phenotype dependent upon gpd-2 and gpd-3, but also the motility of animals exposed to brief periods of anoxia is prematurely arrested in gpd-2/3(RNAi) and daf-2(e1370);gpd-2/3(RNAi) animals [1].

High impact information on gpd-3

  • Previous studies have indicated a relationship between these two events in the processing of a heat shock-induced gpd-2-gpd-3 polycistronic pre-mRNA [2].
  • The G + T-rich and T-rich regions essential for vertebrate beta-globin polyadenylation were also observed for gpd-3 [3].

Biological context of gpd-3


Other interactions of gpd-3

  • These data suggest that gpd-2 and gpd-3 may serve a protective role in tissue exposed to oxygen deprivation [1].


  1. Glyceraldehyde-3-Phosphate Dehydrogenase Mediates Anoxia Response and Survival in Caenorhabditis elegans. Mendenhall, A.R., Larue, B., Padilla, P.A. Genetics (2006) [Pubmed]
  2. Intercistronic region required for polycistronic pre-mRNA processing in Caenorhabditis elegans. Huang, T., Kuersten, S., Deshpande, A.M., Spieth, J., MacMorris, M., Blumenthal, T. Mol. Cell. Biol. (2001) [Pubmed]
  3. Genomic organization of the glyceraldehyde-3-phosphate dehydrogenase gene family of Caenorhabditis elegans. Huang, X.Y., Barrios, L.A., Vonkhorporn, P., Honda, S., Albertson, D.G., Hecht, R.M. J. Mol. Biol. (1989) [Pubmed]
  4. Conservation of gene organization and trans-splicing in the glyceraldehyde-3-phosphate dehydrogenase-encoding genes of Caenorhabditis briggsae. Lee, Y.H., Huang, X.Y., Hirsh, D., Fox, G.E., Hecht, R.M. Gene (1992) [Pubmed]
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