The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

GAPDH  -  glyceraldehyde-3-phosphate dehydrogenase

Canis lupus familiaris

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on GAPDH


Biological context of GAPDH


Anatomical context of GAPDH


Associations of GAPDH with chemical compounds


Other interactions of GAPDH


Analytical, diagnostic and therapeutic context of GAPDH

  • By 24 h reperfusion, no regional differences in GAPDH activity, reaction Vmax or Km, GAP concentrations or GMR were detectable [6].
  • Western blotting revealed no reduction in the levels of GAPDH protein [6].
  • Northern blot analysis indicated that tubulin mRNA levels (normalized to GAPDH mRNA) in HF dogs were upregulated (0.43 +/- 0.04 v 0.13 +/- 0.02; P < 0.01) [20].
  • Immunoblotting further confirmed that training increased left ventricular contents of CS and GAPDH [21].
  • Freshly harvested EC and SMC, isolated from the same aortic sites, were subjected to quantitation of PDGF mRNA levels using a coupled reverse transcriptase and polymerase chain reaction amplification method, with glyceraldehyde-phosphate dehydrogenase (GAPDH) as a control [22].


  1. Physical training alters the pathogenesis of pacing-induced heart failure through endothelium-mediated mechanisms in awake dogs. Wang, J., Yi, G.H., Knecht, M., Cai, B.L., Poposkis, S., Packer, M., Burkhoff, D. Circulation (1997) [Pubmed]
  2. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Sessa, W.C., Pritchard, K., Seyedi, N., Wang, J., Hintze, T.H. Circ. Res. (1994) [Pubmed]
  3. Purification and characterization of beta-actin-rich tumor cell pseudopodia: role of glycolysis. Nguyen, T.N., Wang, H.J., Zalzal, S., Nanci, A., Nabi, I.R. Exp. Cell Res. (2000) [Pubmed]
  4. Differential mitochondrial DNA and gene expression in inherited retinal dysplasia in miniature schnauzer dogs. Appleyard, G.D., Forsyth, G.W., Kiehlbauch, L.M., Sigfrid, K.N., Hanik, H.L., Quon, A., Loewen, M.E., Grahn, B.H. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  5. Carnitine palmitoyl transferase-I inhibition prevents ventricular remodeling and delays decompensation in pacing-induced heart failure. Lionetti, V., Linke, A., Chandler, M.P., Young, M.E., Penn, M.S., Gupte, S., d'Agostino, C., Hintze, T.H., Stanley, W.C., Recchia, F.A. Cardiovasc. Res. (2005) [Pubmed]
  6. Inhibition of glyceraldehyde-3-phosphate dehydrogenase in post-ischaemic myocardium. Knight, R.J., Kofoed, K.F., Schelbert, H.R., Buxton, D.B. Cardiovasc. Res. (1996) [Pubmed]
  7. Increased expression of pro-inflammatory cytokines and lack of up-regulation of anti-inflammatory cytokines in early distemper CNS lesions. Markus, S., Failing, K., Baumgärtner, W. J. Neuroimmunol. (2002) [Pubmed]
  8. Detection of canine cytokine gene expression by reverse transcription-polymerase chain reaction. Pinelli, E., van der Kaaij, S.Y., Slappendel, R., Fragio, C., Ruitenberg, E.J., Bernadina, W., Rutten, V.P. Vet. Immunol. Immunopathol. (1999) [Pubmed]
  9. Actions of thiocyanate and N-phenylmaleimide on volume-responsive Na and K transport in dog red cells. Parker, J.C., Colclasure, G.C. Am. J. Physiol. (1992) [Pubmed]
  10. Nuclear receptor and nuclear receptor target gene messenger ribonucleic acid levels at different sites of the gastrointestinal tract and in liver of healthy dogs. Gropp, F.N., Greger, D.L., Morel, C., Sauter, S., Blum, J.W. J. Anim. Sci. (2006) [Pubmed]
  11. Biochemical mechanism of infarct size reduction by pyruvate. Regitz, V., Azumi, T., Stephan, H., Naujocks, S., Schaper, W. Cardiovasc. Res. (1981) [Pubmed]
  12. Characterization of the blood-brain barrier: protein composition of the capillary endothelial cell membrane. Lidinsky, W.A., Drewes, L.R. J. Neurochem. (1983) [Pubmed]
  13. Measurement of messenger RNA encoding the alpha-chain, polymeric immunoglobulin receptor, and J-chain in duodenal mucosa from dogs with and without chronic diarrhea by use of quantitative real-time reverse transcription-polymerase chain reaction assays. Peters, I.R., Helps, C.R., Calvert, E.L., Hall, E.J., Day, M.J. Am. J. Vet. Res. (2005) [Pubmed]
  14. A comparison of various "housekeeping" probes for northern analysis of normal and osteoarthritic articular cartilage RNA. Matyas, J.R., Huang, D., Adams, M.E. Connect. Tissue Res. (1999) [Pubmed]
  15. Myocardial proteome analysis reveals reduced NOS inhibition and enhanced glycolytic capacity in areas of low local blood flow. Laussmann, T., Janosi, R.A., Fingas, C.D., Schlieper, G.R., Schlack, W., Schrader, J., Decking, U.K. FASEB J. (2002) [Pubmed]
  16. Post-mortem biochemistry of beagle dog lenses after treatment with Fluvastatin (Sandoz) for 2 years at different dose levels. Hockwin, O., Evans, M., Roberts, S.A., Stoll, R.E. Lens and eye toxicity research. (1990) [Pubmed]
  17. Reduced synthesis of NO causes marked alterations in myocardial substrate metabolism in conscious dogs. Recchia, F.A., Osorio, J.C., Chandler, M.P., Xu, X., Panchal, A.R., Lopaschuk, G.D., Hintze, T.H., Stanley, W.C. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  18. Dobutamine enhances both contractile function and energy reserves in hypoperfused canine right ventricle. Yi, K.D., Downey, H.F., Bian, X., Fu, M., Mallet, R.T. Am. J. Physiol. Heart Circ. Physiol. (2000) [Pubmed]
  19. RT-PCR amplification of various canine cytokines and so-called house-keeping genes in a species-specific macrophage cell line (DH82) and canine peripheral blood leukocytes. Gröne, A., Fonfara, S., Markus, S., Baumgärtner, W. Zentralblatt Veterinarmedizin Reihe B (1999) [Pubmed]
  20. Role of microtubules in the contractile dysfunction of myocytes from tachycardia-induced dilated cardiomyopathy. Takahashi, M., Tsutsui, H., Kinugawa, S., Igarashi-Saito, K., Yamamoto, S., Yamamoto, M., Tagawa, H., Imanaka-Yoshida, K., Egashira, K., Takeshita, A. J. Mol. Cell. Cardiol. (1998) [Pubmed]
  21. Exercise training enhances glycolytic and oxidative enzymes in canine ventricular myocardium. Stuewe, S.R., Gwirtz, P.A., Agarwal, N., Mallet, R.T. J. Mol. Cell. Cardiol. (2000) [Pubmed]
  22. Regional differences in platelet-derived growth factor production by the canine aorta. Madura, J.A., Kaufman, B.R., Margolin, D.A., Spencer, D.M., Fox, P.L., Graham, L.M. J. Vasc. Res. (1996) [Pubmed]
WikiGenes - Universities