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Gene Review

car1  -  arginase Car1

Schizosaccharomyces pombe 972h-

 
 
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Disease relevance of car1

 

High impact information on car1

  • It seems that immediate arginase degradation is initiated by starved cells or ones from which arginine has been removed [2].
  • Induction of arginase and ornithine transaminase in the fission yeast Schizosaccharomyces pombe [2].
  • Amiloride-resistant mutants were isolated and shown to represent a new locus (car1 for changed amiloride resistance) on chromosome I. The car1 gene was cloned and sequenced [3].
  • We propose that car1 serves an uptake function, perhaps as a symport with an unknown substrate and this carrier may transport amiloride into the cell [3].
  • Gene disruption of car1 results in increased amiloride resistance. car1 has sequence similarity to proteins from Candida associated with resistance to benomyl, methotrexate and cycloheximide [3].

References

  1. Amiloride toxicity in the fission yeast Schizosaccharomyces pombe is released by thiamine and mutations in the thiamine-repressible gene car1. Niederberger, C., Fankhauser, H., Edenharter, E., Schweingruber, M.E. Gene (1996) [Pubmed]
  2. Induction of arginase and ornithine transaminase in the fission yeast Schizosaccharomyces pombe. Benítez, T., Farrar, L. J. Bacteriol. (1980) [Pubmed]
  3. The amiloride resistance gene, car1, of Schizosaccharomyces pombe. Jia, Z.P., McCullough, N., Wong, L., Young, P.G. Mol. Gen. Genet. (1993) [Pubmed]
 
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