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Gene Review

cdc8  -  tropomyosin

Schizosaccharomyces pombe 972h-

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High impact information on cdc8


Biological context of cdc8

  • Collectively these results indicate that cdc8 tropomyosin has a specialized role which, we suggest, is to form part of the F-actin contractile ring at cytokinesis [1].
  • Additional cdc8 mutants isolated by targeted mutagenesis also showed defects in both cell fusion and cytokinesis [3].
  • In fission yeast, the cdc8 gene encodes tropomyosin, and the gene product Cdc8p is known to be essential for the formation of the F-actin contractile ring and hence for cytokinesis in the mitotic cell cycle [3].

Analytical, diagnostic and therapeutic context of cdc8

  • Immunofluorescence microscopy of wild type and cdc8 gene disruptants indicates that cdc8 tropomyosin is present in two distinct cellular distributions: in dispersed patches, and during cytokinesis as a transient medial band [1].


  1. A new tropomyosin essential for cytokinesis in the fission yeast S. pombe. Balasubramanian, M.K., Helfman, D.M., Hemmingsen, S.M. Nature (1992) [Pubmed]
  2. Ssp1 promotes actin depolymerization and is involved in stress response and new end take-off control in fission yeast. Rupes, I., Jia, Z., Young, P.G. Mol. Biol. Cell (1999) [Pubmed]
  3. Tropomyosin is required for the cell fusion process during conjugation in fission yeast. Kurahashi, H., Imai, Y., Yamamoto, M. Genes Cells (2002) [Pubmed]
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